UPDATED September 01, 2020 – MS or Multiple sclerosis is also called disseminated sclerosis or encephalomyelitis disseminata. MS is a disorder where the myelin sheath around the axons of our brains and spinal cord are damaged, leading to demyelination and scarring in addition to a comprehensive spectrum of indications and symptoms that are commonly referred to as Multiple sclerosis.
What Is MS?
Over time, MS changes the ability of nerve cells and the spinal cord to communicate with each other. Nerve cells generally communicate by sending electrical signals down long fibers known as axons. Axons are wrapped in an insulating bio-material called myelin. In MS, our body’s immune system attacks and damages the myelin sheath. When our myelin is lost, axons can no longer efficiently conduct signals or communicate as they normally do.
The term sclerosis refers to scars, plaques, or lesions in the white matter of our brain and spinal cord that is primarily composed of myelin. Although we know much about the mechanisms and symptoms or this degenerative disease, the causes of autoimmune multiple sclerosis vs myasthenia gravis remains relatively unknown. Several neurological and immune system symptoms can appear with MS disorder, and frequently, the symptoms progress to display severe physical and cognitive impairment. New symptoms can occur rapidly or occur slowly over time. The slow appearance of symptoms is known as Multiple progressive sclerosis. The symptoms of MS can sometimes go away entirely on their own but can also lead to irreversible neurological degeneration seen in spinal cord injuries, Parkinson’s disease, and particularly in Primary Progressive Multiple Sclerosis.
Neurological testing can help identify the disorder whose primary features are: myelinolysis in patients brains and spinal cord. The demyelinating disease primarily affects the “CNS” or central nervous system. A well-known type of demyelinating disease is known as Multiple sclerosis or MS.
Categorization of MS & Balos Disease:
- MS or Multiple Sclerosis
- Acute multiple sclerosis
- Persistent cerebral cord sclerosis
- Balo concentric diffuse cerebral sclerosis
- Diffuse cerebral sclerosis – Schilder’s disease
- Inflammation of Optic nerve myelin – Devic’s disease
- Acute disseminated encephalomyelitis
- Necrotizing hemorrhagic encephalitis – Sub-acute and Acute
4 Variations of Multiple Sclerosis
- RRMS or Relapsing-Remitting Multiple Sclerosis: The most common type of MS we treat. RRMS symptoms include repeat attacks with progressive loss of nerve functions after each attack, followed by a period of remission where the normal function is partially or restored restored without flareups or Exacerbations.
- SPMS or Secondary Progressive Multiple Sclerosis Stage: SPMS usually follows RRMS after continued attacks. This stage results in progressive neurological damage that is associated with death of motor neurons & nerve demyelination.
- PPMS or Primary Progressive Multiple Sclerosis: This stage represents a steady decline with no intermittent remissions, exacerbations or Flare-Ups
- PRMS or Progressive Relapsing Multiple Sclerosis Stage: PRMS is the rarest type of MS that affects people and the most difficult to treat. Most patients will not qualify for stem cell transplants and the patients that are usually recommended an aggressive cell protocol as part of a combination therapy that includes Immunosuppressive techniques to slow down the rapidly progressing condition.
MS is amongst the most severe and complicated nervous system disorders to treat that we have today in the field of regenerative medicine. MS Disorder frequently invades specific regions of the human nervous system, causing intense exhaustion along with other symptoms and clear physical signs that can be readily identifiable using radiology scans.
Clinical indications of MS include:
- Motor weakness (sometimes misdiagnosed as fibromyalgia )
- Visual impairments
- Limb paresis, strokes or paralysis (sometimes misdiagnosed as systemic lupus erythematosus)
- Avascular necrosis
- Orthopedic and Shoulder Injuries
- Peripheral Neuropathic Pain
- Motor Neuron Disease MND
- Bladder dysfunction and urinary incontinence or IBD
Lab evaluation for MS usually requires detailed cytology of the patients cerebrospinal fluid, along with detailed protein analysis and Radiographic examinations for areas around the encephalocele. Genetic tests and Radiographic exams look for multiple or isolated lesions in the brain. Nearly half of the patients we treat for MS using neural progenitor cells, interferon Beta and HSCT (Hematopoietic stem cells) show improvement shortly after treatment while some patients show continuing improvement that lasts over a few years.
Multiple Sclerosis Treatment w/ Cell Transplants
The Regeneration Center has developed a multistage program to treat MS. Nerve Cells, exosomes, Brain stem cells and neurons are able properly to regenerate damaged areas of nerve myelin and axons while mesenchymal stem cells help to reverse any autoimmune damage. This alone can slow down, stop, or even reverse the progressive nature of MS while the enriched neural cells & neural progenitor cells can target the brain lesions that exist.
TREATMENT PRECAUTIONS & RISKSPlease Note That Not All Patients will Qualify for Treatment of Degenerative Neurological conditions such as MS. Patients with late stage, severe underlying conditions, recent heart attacks or travel restrictions may not qualify for the 2-3 week treatment protocol in Bangkok.
1 Year After Stem Cell Therapy for Multiple Sclerosis
Total Number of Cell Treatments will depend on Patient Needs.
Type of Injections: For patients with progressive MS, a more aggressive combination therapy will be required. Our cell infusions are done over multiple dates and do not require invasive surgery. The cells are target delivered via a Guided Radio Scanner (when necessary) or more commonly through an Intravenous Drip, Stem Cell Nebulizer, Direct injection or Intrathecal Injections.
Physical Rehabilitation Post-Therapy: Physical Rehabilitation therapy for MS in Bangkok is optional, depending on the patients’ travel/time constraints. Complete physical rehabilitation post-therapy and can be provided upon request for 2-5 hours per day and up to 5 days per week. Medical visas and extended stay accommodations for the patients and family can also be included upon request.
MS Treatment Guidelines for 2020
Due to the varying degrees of existing medical conditions and the stage of degeneration, our medical team will need to review the potential candidates current and actual medical condition before a treatment protocol can be established. Upon acceptance, we can provide a more accurate assessment of the patient condition and what we expect to achieve post-therapy. The final plan will include a day by day treatment outline with total number nights required along with the full and fixed medical related expenses (excluding accommodations or flights). Stem Cell Therapy for MS using MSc cells will require a minimum of 14-21 nights in Bangkok. To begin the qualification process for our multi-stage MS Treatment protocol, please prepare your recent medical records such as Brain MRI’s, CT Scans, or PET Scans (Preferred ) and contact us today.
To learn more about Treatment for MS with Stem cells please contact us today.
Published Clinical Citations
 ^ Pipatpajong, Hemmarin, and Kammant Phanthumchinda. 2011. Neurofibromatosis type I associated multiple sclerosis. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, no. 4. https://www.ncbi.nlm.nih.gov/pubmed/21591539
 ^ Laosanguanek, Naressak, Thaddao Wiroteurairuang, Sasitorn Siritho, and Naraporn Prayoonwiwat. 2011. Reliability of the Thai version of SF-36 questionnaire for an evaluation of quality of life in multiple sclerosis patients in multiple sclerosis clinic at Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. https://www.ncbi.nlm.nih.gov/pubmed/21721432
 ^ Hou, Zong-liu, Ying Liu, Xi-Hong Mao, Chuan-yu Wei, Ming-yao Meng, Yun-hong Liu, Zara Zhuyun Yang, et al. 2013. Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis. Cell adhesion & migration, no. 5 (October 30). doi:10.4161/cam.26941. https://www.ncbi.nlm.nih.gov/pubmed/24192520