stem cells treatment for Multiple Sclerosis

Stem Cell Treatment for Multiple Sclerosis – MS PLS HSCT

MS or Multiple sclerosis is also called disseminated sclerosis or encephalomyelitis disseminata. MS is a disorder where the myelin sheath around the axons of our brains and spinal cord are damaged, leading to demyelination and scarring in addition to a comprehensive spectrum of indications and symptoms that are commonly referred to as Multiple sclerosis.

What Is MS?

Over time, MS changes the ability of nerve cells, immune cells and the spinal cord to communicate with each other. Nerve cells generally communicate by sending electrical signals down long fibers known as axons. Axons are wrapped in an insulating reparing-myelin-sheath-damage-thailandbio-material called myelin. In MS, our body’s immune system attacks and damages the myelin sheath. When our myelin is lost, axons can no longer efficiently conduct signals or communicate as they normally do.[1]

The term sclerosis refers to scars, plaques, or lesions in the white matter of our brain and spinal cord that is primarily composed of myelin. Although we know much about the mechanisms and symptoms or this degenerative disease, the causes of autoimmune multiple sclerosis ms vs myasthenia gravis remains relatively unknown. Several neurological and immune system symptoms can appear with MS disorder, and frequently, the symptoms progress to display severe physical and cognitive impairment. New symptoms for people with ms can occur rapidly or can occur slowly after related illnesses such as transverse myelitis. The slow appearance of symptoms is known as Multiple progressive sclerosis. The symptoms of MS can sometimes go away entirely on their own but can also lead to irreversible neurological degeneration seen in spinal cord injuriesParkinson’s disease, and particularly in Primary Progressive Multiple Sclerosis.[2]

Neurological testing can help identify the disorder whose primary features are: myelinolysis in patients brains and spinal cord. The demyelinating disease primarily affects the “CNS” or central nervous system. A well-known type of demyelinating disease is known as Multiple sclerosis or MS.[3]

Categorization of MS & Balos Disease:

symptoms-of-MS

  1. MS or Multiple Sclerosis
  2. Acute Multiple sclerosis – Progressive MS
  3. Persistent cerebral cord sclerosis
  4. Balo concentric diffuse cerebral sclerosis
  5. Diffuse cerebral sclerosis – Schilder’s disease
  6. Inflammation of Optic nerve myelin  – Devic’s disease
  7. Acute disseminated encephalomyelitis
  8. Necrotizing hemorrhagic encephalitis – Sub-acute and Acute

4 Variations of Multiple Sclerosis

  1. RRMS or Relapsing-Remitting Multiple Sclerosis (relapsing remitting ms):  The most common type of MS we treat. RRMS symptoms include repeat attacks with progressive loss of nerve functions after each attack, followed by a period of remission where the normal function is partially or restored restored without flareups or Exacerbations.
  2. SPMS or Secondary Progressive Multiple Sclerosis Stage:  Secondary progressive ms or SPMS usually follows RRMS after continued attacks. This stage results in progressive neurological damage that is associated with death of motor neurons & nerve demyelination.
  3. PPMS or Primary Progressive Multiple Sclerosis MS:  This stage represents a steady decline with no intermittent remissions, exacerbations or Flare-Ups
  4. PRMS or Progressive Relapsing Multiple Sclerosis Stage: PRMS is the rarest type of MS that affects people and the most difficult to treat. Most patients will not qualify for stem cell transplants and the patients that are usually recommended an aggressive cell protocol as part of a combination therapy that includes Immunosuppressive techniques to have positive effect and slow down the rapidly progressing condition.

MS is amongst the most severe and complicated nervous system disorders to treat that we have today in the field of regenerative medicine. MS Disorder frequently invades specific regions of the human nervous system, causing intense exhaustion along with other relapsing ms symptoms and clear physical signs that can be readily identifiable using radiology scans such as MRI scan.

Clinical indications of MS include:

Lab evaluation for people with ms or relapsing ms usually requires detailed cytology of the patients cerebrospinal fluid, along with detailed protein analysis and Radiographic MRI scan examinations for areas around the encephalocele. Genetic tests and Radiographic exams look for multiple or isolated lesions in the brain. Stem cell research shows that over 65% of the patients treated for MS using neural progenitor cells,undifferentiated cells, interferon Beta and HSCT (Hematopoietic stem cells) show improvement shortly after treatment while some patients show continuing improvement that lasts over a few years.

Mesenchymal Stem Cells for Multiple Sclerosis

Stem cells are (undifferentiated / undefined) cells that have the ability of perpetual self-renewal and have unique properties that can produce specialized cells through cell division. Stem cells are usually categorized into either embryonic stem cells or adult stem cells. Embryonic stem cells lines (ESC) are pluripotent and can give rise to all cell types in the body and have the ability to differentiate into different tissue types Embryonic cells are acquired from the inner cell mass of a blastocyst but can lead to serious adverse events. Due to strict safety standards The Regeneration Center does not offer human embryonic stem cells or iPSC cells. Learn more about the basics of stem cells

What Are Stem Cells

Adult stem cells uses in treatment for amyotrophic lateral sclerosis and progressive ms have the capacity to begin the healing process by differentiating into many other cell types and are considered multipotent. Their main purpose of adult stem cells & immune cells is to repair the body or produce additional specialized cells needed to reduce inflammation. This need usually arises due to wear and tear, acute injury, or disease and infections. Adult stem cells can be found in many organs and damaged tissues in the body and are further divided into different categories depending on where they are found. Adult stem cells are either:

Mesenchymal stromal cells and growth factors needed to improve essential functions can be found in several areas including: MSC-stemcells-Multiple-Sclerosis

Mesenchymal stem cells have unique properties and can be cultured & differentiated (MSC+) into many types of new cells, including:

  • Cartilage Cells
  • Fat cells
  • Skin cells
  • Bone Cells
  • Ligament
  • Tendon Cells
  • Muscles cells
  • Nerve cells

More recently a reprogrammed pluripotent stem cells known as induced pluripotent stem cells (iPSCs). Induced pluripotent stem cells have similar features to embryonic stem cells, however, carry the risk of tumor formation. This risk of cancer can be reduced via transdifferentiation however the results have not been very consistent or safe. Progenitor stem cells such as induced oligodendrocyte progenitor cells (iOPC), induced neural stem cells (iNSC) and oligodendrocytes (iOL) can also be derived from somatic adult cell type via the process of transdifferentiation

Effective treatment for MS – HSCT

Hematopoietic stem cells have the ability of pluripotentiality and self-renewal ability but only found in less than 0.01% of all nucleated cells in the Bone Marrow. Hematopoietic stem cells are capable of forming all hematopoietic cell lines including:

  • Megakaryocytes
  • Platelets
  • Erythrocytes
  • Adaptive immune system cells
  • Innate immune system cells

Isolated Hematopoietic cells (HSC+) can lead to self-renewal to regenerate damaged nerves using hematopoietic cell types when the new cells are transplanted to patients. HSC cell transplantation (HSCT) has been used for over 50 years as a therapeutic tool to fight cancer and high dose immunosuppressive therapy to avoid risk of ms relapses and rebuild the Immune system after chemotherapy.

Disease modifying therapies to treat multiple sclerosis

Clinical studies and peer reviewed studies have shown that haematopoietic stem cells & autologous hematopoietic stem cell are also effective in repairing nerve insulating myelin caused by various autoimmune conditions including autoimmune encephalomyelitis (experimental autoimmune encephalomyelitis) has become a viable alternative therapy (with alternative to immunosuppressive and immunomodulatory medications needed in autoimmune diseases such as MS. Results are achieved by several ways including rebooting the immune system and/or elimination of autoantigen-reactive T and B lymphocytes along with increasing the populations of t regulatory cells,

How is Effectiveness Measured?

The treatment effectiveness for ms therapies is measured several ways including:

  • Relapse-free survival rate
  • Progression-free survival rate
  • MRI event-free survival
  • Disease-free survival
  • Sustained reduction in disability EDSS score

New treatment for MS – Mechanisms of Action

Double blind stem cell research has shown that MSC+ mesenchymal cells act as catalysts for improvement of inflammatory diseases via several mechanisms including:

  • Immunomodulation
  • Immunosuppression
  • Neurotrophic repair functions from neural cells for neurological disorders

Long term benefits of MSC+ stem cells for neurological conditions can include inhibited adaptive immune responses, stop disease progression, creating new white blood cells repairing nerve insulating myelin, inhibit innate immune responses, proliferation of regulatory t cells,white blood cells, B cells & NK cells

Is Multiple Sclerosis Genetic Testing Available?

MS is generally not considered a hereditary disease but there are over 100 genetic markers that have been identified as increasing the risk of getting MS. Clinical trials, mRNA vaccines, and gene therapies are being developed to target genetic defects using several gene-editing methods including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 systems. Gene testing is till in its very early days however the early patients showed improvement. The goal of these new promising alternative treatments for MS would be to use the combination of stem cell therapy after completion of genome editing or mRNA vaccines which is currently in clinical trials.

Treatment for Progressive MS w/ Stem Cells in 2024

The Regeneration Center has developed a multistage program to treat MS. Nerve Cells and nerve fibers, exosomes, Brain stem cells and neurons are able properly to regenerate damaged areas of nerve myelin and axons while mesenchymal stem cells help to reverse any damage caused by autoimmune disease. This alone can slow down, stop, or even reverse the progressive nature of MS while the enriched neural cells, glial cells astrocytes & neural progenitor cells can target the brain lesions that exist.

TREATMENT PRECAUTIONS & SIDE EFFECT RISKS
Please note MSC+ therapy is not appropriate for all conditions and cases.  Patients with multiple comorbidities, degenerative Neurological conditions, late stage MS diagnosis, active progressive multiple sclerosis, severe underlying conditions, irreversible disability, multiple neurological conditions, side effects from recent immune response or heart attack or travel restrictions may not qualify for the 2-3 week treatment protocol in Bangkok.

1 Yr After Stem Cell Therapy for Progressive Multiple Sclerosis

MS Stem Cell Therapy Overview

Total Number & Types of Stem Cells – Depend on patient medical needs.

Type of Injections: For patients with progressive MS, late stage MS, treatment of multiple sclerosis may require more aggressive combination therapy using different types of stem cells including hematopoietic stem cell transplantation and bone marrow stem cells. To ensure long term efficacy the cell infusions are done over multiple dates and do not require invasive surgery. The cells are delivered via a Guided Radio Scanner (when necessary) or more commonly through an Intravenous Drip, Stem Cell nebulizer, direct injection or Intrathecal Injections of stem cells.

Physical Rehabilitation Post-Therapy: Physical Rehabilitation therapy for MS in Bangkok is optional, depending on the patients’ travel/time constraints. Complete physical rehabilitation post-therapy and can be provided upon request for 2-5 hours per day and up to 5 days per week. 
Medical visas and extended stay accommodations for the patients and family can also be included upon request.Learn about a multiple sclerosis friendly diet.

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Cost of Treatment for MS with Stem Cells – 2024

Due to the varying degrees of existing medical conditions (edss scores) and the stage of degeneration, our medical team will need to review a potential candidates current medical information before a treatment protocol can be established without increased risk. Upon acceptance, we can provide a more accurate assessment of the patient condition and what we expect to achieve post-therapy. The final plan will include a day by day treatment outline with total number nights required along with the full and fixed medical related expenses (excluding accommodations or flights). Stem Cell Therapy for MS will require a minimum of 14 days in Bangkok.  To begin the qualification process for our multi-stage MS Treatment protocol, please prepare your recent medical records such as Brain MRI’s, CT Scans, or PET Scans (Preferred to identify new lesions ) and contact us today.

To learn more about Treatment for MS with Isolated MSC+ Stem cells please contact us today.

Published Clinical Citations

[1] ^ Pipatpajong, Hemmarin, and Kammant Phanthumchinda. 2011. Neurofibromatosis type I associated multiple sclerosis. Journal of the Medical Association of Thailand, Chotmaihet thangphaet, no. 4. https://www.ncbi.nlm.nih.gov/pubmed/21591539

[2] ^ Laosanguanek, Naressak, Thaddao Wiroteurairuang, Sasitorn Siritho, and Naraporn Prayoonwiwat. 2011. Reliability of the Thai version of SF-36 questionnaire for an evaluation of quality of life in multiple sclerosis patients in multiple sclerosis clinic at Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. https://www.ncbi.nlm.nih.gov/pubmed/21721432

[3] ^ Hou, Zong-liu, Ying Liu, Xi-Hong Mao, Chuan-yu Wei, Ming-yao Meng, Yun-hong Liu, Zara Zhuyun Yang, et al. 2013. Transplantation of umbilical cord and bone marrow-derived mesenchymal stromal stem cells in a patient with relapsing-remitting multiple sclerosis ms, progressive ms with neural cells adhesion & migration, no. 5 (October 30). doi:10.4161/cam.26941. https://www.ncbi.nlm.nih.gov/pubmed/24192520

Page last updated: 05 February 2024 | Topic last reviewed: 11 September 2023