Cellular Treatment for Peripheral Neuropathy & Polyneuropathy Pain

UPDATED March 17, 2020 – An estimated 175 million people in the world have some type of peripheral neuropathy or “PN” which accounts to nearly 8% of the global population. PR disease develops over time due to damage to our communication network known as the peripheral nervous system. Neuropathy means nerve damage or never disease/disorder of signals between our brain and spinal cord (central nervous system) and other parts of our bodies. Human Peripheral nerves are responsible for sending sensory information to our brain and spinal cord. The Peripheral nerves are also responsible for carrying movement signals from our spinal cord and brain to generate proper muscle movement. Any damage to our peripheral nervous system will interfere with these signals similar to static in a tv or telephone signal. A patient with peripheral neuropathy is unable to communicate properly between his/her brain and spinal cord due to the interference in the signal. (27004308)

Peripheral Neuropathy & Nerve Damage

Symptoms of Peripheral Nerve Damage

Symptoms for patients peripheral nerve damage depends entirely on which type of nerves are damaged ( motor nerves, sensory nerves or autonomic ). As the name suggest, Motor nerves help control our voluntary responses of muscles needed in actions such as grabbing things, walking or talking. Sensory nerves are responsible for transmitting the brain information about touch or pain injuries. Autonomic nerves are non-voluntary and help manage proper organ functions such as digesting food, beating the heart or breathing. We do not have to think about breathing in and out our lungs manage the process automatically. Some rare cases of peripheral neuropathies can affect all 2 types of nerves but most diagnosis for patients usually effect just one or two types of nerve damage.

Most diagnosis of peripheral nerve disease are categorized as one of the following:peripheral-neuropathy-treatment

  • Autonomic neuropathy
  • Idiopathic Peripheral Neuropathy
  • Predominantly sensory neuropathy
  • Predominantly motor neuropathy
  • Sensory-motor neuropathy
  • Diabetic neuropathy
  • Small fiber neuropathy
  • Alcoholic neuropathy
  • Multifocal motor neuropathy
  • Optic neuropathy
  • Peroneal neuropathy

Damage to the Motor nerves is commonly seen as muscle weakness but may also produce uncontrolled muscle twitches (fasciculations), painful muscle cramps, muscle atrophy with decreased reflexes similar to patients who are diagnosed with Ataxia, ALS, Motor Neuron Disease, Alzheimer and Parkinson’s disease. A diagnosis of sensory nerve disease manifests itself as a variety of symptoms due to their broad range of uses/functions. Large sensory fibers in myelin sheath are responsible for identifying vibrations and light touches. Any damage to the large sensory fibers will impair the sensation of touch. This type of nerve damage affects the hands and feet causing them to feel like they are wearing a pair of gloves on the hands or stockings on the legs even though they are not wearing either. This type of damage makes men and women unable to coordinate complex muscle movements like running or fastening shirts, or even maintain proper balance when eyes are closed.

Neuropathic Pain

Smaller sensory fibers are responsible for transmitting the sensation of temperatures and pain. Patients diagnosed with damage to smaller sensory fibers may not be able to sense injury from an accident or that a wound has become infected. They also might not be able to detect the bodies signal of chest pain ( impending heart attack ). The Loss of our pain sensation is especially critical for patients with diabetic induced neuropathy results in a very high rate of limb amputations. Diabetic neuropathy is one of the most common types of peripheral nerve disease.(26225666)

Neuropathic induced pain is a very common condition that seriously affects the emotional well-being and quality of life for a patient. Neuropathic pain also disrupts sleep further compounding the physical burden of having sensory nerve damage. Neuropathic pain and allodynia are associated with hypersensitization of pain receptors in our skin resulting in the feeling of severe pain from stimuli that would normally be painless. If left untreated, sensory neuropathy will lead to negative changes in a patients hair, skin/joints resulting in ligament damage, bone damage & osteoarthritis.


Autonomic nerve disease symptoms are also very diverse in nature due to the fact that our sympathetic & parasympathetic nerves just about every organ in the human body. Commonly associated symptoms of autonomic nerve damage “AND” include the inability to perspire/sweat normally resulting in heat intolerance and can be identified using modern functional medical tests. Other symptoms include:

reverse-diabetic-neuropathyMost patients with autonomic neuropathy also display gastrointestinal symptoms due to a nerve malfunction of the intestinal muscle contractions which leads to incontinence, diarrhea, and constipation along with problems eating or swallowing.

Symptoms of peripheral nerve damage can be experienced over a few days, months, or years and can be classified as acute or chronic. Acute neuropathies occur when symptoms appear unexpectedly, progress rapidly, and resolve very slowly. In chronic neuropathies, symptoms usually appear subtly and progress very slow. Some patients may show signs of relief followed by relapse in symptoms. For others, they reach a plateau where symptoms usually stay consistently the same for months or even years. Most cases of chronic peripheral neuropathy worsen over time and become extremely painful and debilitating with some cases becoming terminal due to compounding medical issues such as diabetes or brain strokes. (22553278)

The Primary Causes of  Neuropathy disease include:

  1. Diabetes mellitus. The most common cause of PN, research has shown that about 45% of diabetics eventually develop peripheral neuropathy disease or Diabetic nephropathy which leads to Polycystic kidney disease, heart attacks and/or Kidney Failure
  2. Toxic Exposure. The most common toxins found in alcoholic drinks (alcoholic neuropathy). Exposure to Chemotherapy and lead are also known causes of peripheral nerve damage and ataxia.
  3. Systemic organ failures due to hypothyroidism, vitamin deficiencies or other diseases such as herpes or HIV infections.
  4. Autoimmune Diseases including Systemic lupus erythematosus (SLE), Guillain-Barre’ syndrome and CIPD (Chronic Inflammatory Demyelinating Polyneuropathy)
  5. Hereditary – Genetic predisposition to PND
  6. Environmental factors that occur due to repeated injuries or severe hypothermia
  7. Idiopathic causes – Idiopathic means that the cause is unknown and up to 20% of patients diagnosed with the disease can fall into this category.

Diagnosis of Peripheral Neuropathy

The diagnosis of Peripheral neuropathy requires multiple tests to confirm and it has many potential causes. A patient displaying symptoms should start with a full physical exam including blood tests. To confirm a diagnosis further testing is usually needed. Tests include:

  • Neurological examination – To check tendon reflex, muscle strength and the ability to feel sensations along with checking coordination and physical posture.
  • Blood tests – to check for diabetes, vitamin deficiencies, abnormal immune responses, and other indications.
  • Genetic Testing for Hereditary Neuropathy
  • Imaging tests. MRI or CT to look for any herniated or degenerative spinal disks, tumors or other abnormalities that might be causing the improper nerve response.
  • Nerve function tests such as “EMG” ( Electromyography ) to measure electrical activity in the muscles and detect any nerve damage. An electrical probe sends signals to the nerves, and an electrode is placed along the pathway to record/measure the nerve’s response. This type of test is also known as a nerve conduction test.

Please note that not all patients are good candidates for the treatment of Neuropathy with Stem cells or stem cell therapy for nerve damage. Patients with late stage, severe underlying conditions or travel restrictions may not qualify for the 2-week treatment protocol.

Natural Treatment for Neuropathy Pain w/o Side Effects

Treatment options for polyneuropathy depend on the underlying causes. For patients with diabetes or vitamin deficiencies, treatment often entails directly treating the underlying cause of their peripheral neuropathy diagnosis. Other measures such as removing toxins or negative environmental factors can be used to treat mild conditions. Patients diagnosed with autoimmune neuropathy usually require much more aggressive therapies including:

  1. Intravenous Immunoglobulin therapy
  2. Therapeutic plasma exchange (TPE)
  3. Glucocorticoids therapy (High dose steroids)

Current medications such as carbamazepine, Gabapentin, topiramate, Tricyclic antidepressant medications ( amitriptyline desipramine), Pain medications like ibuprofen or tramadol are used to mask the symptoms but do not do much as far as treatment of the underlying causes.

1 Year After Stem Cell Therapy Nerve Damage (Foot Drop)

Stem Cell Therapy for Neuropathy

Mesenchymal Stem cell therapy (MSC+) and paracrine signaling offer a unique and effective modern treatment option for patients suffering from neuropathy nerve damage and neuropathic pain. Unlike traditional treatments that respond poorly to opioid and OTC analgesics our MSC+ enhanced cell therapy uses a multi-layer combination therapy consisting of MSC+ hematopoietic expanding-mesenchymal-stem-cell-transplantsstem cells, leukocytes, red blood cells, CD90 positive cells, CD31 positive cells, CD45 cells and endothelial cells to precisely repairing the damage on the tissue nerve level and recover lost functions. MSC Stem cell treatments focus on the root of the underlying issue (nerve damage) not just temporarily mask the symptoms with pain killers.

We treat neuropathic pain and create anti-inflammatory zones through the release of cytokines that play a vital role in nerve regeneration. The cell injection protocol we offer have been clinically proven to decrease proinflammatory (IL)-1β interleukin cytokine while increasing the anti-inflammatory (IL-10) cytokines in the lesioned nerve, along with a significant reduction in mechanical allodynia & thermal hyperalgesia. The general consensus among our patients who had stem cell therapy for pain reduction was overwhelmingly beneficial and positive after the 1-2 week stem cell therapy. The treatment we offer is very safe with minimal side effects such as drowsiness and minor weight gain.(23134736)

The cells used in the treatment are multipotent hematopoietic & undifferentiated cells taken from adult sources depending on the patients’ needs. The harvested cells are non-immunogenic and 100% matched to the patient.(25975801)

Neuropathy Treatment Evaluation, Guidelines & Costs

Get safe, affordable and permanent treatment for Neuropathy at the Regeneration Centre. It you or a loved one are suffering from neuropathic pain or neuropathy you/they are probably in unnecessary physical agony and should try to get out of the painful situation as early as possible. Having a clear diagnosis with recent test results is an important step in treating the condition with stem cells. Our request for a medical review can be done online and will enable our doctors to better understand your need before suggesting an effective protocol that will be used to treat this condition. Please note the treatment does take place in Thailand and will require travel to our stem cell hospital for a period of 1-2 weeks. Our pain management solutions help solve the root of the pain issues to safely improve the quality of life for our patients. If your daily activities are being affected by neuropathy, please contact us today. Our team of medical professionals are experienced and trained in dealing with several types of pain conditions to ensure your condition improves as quickly as possible so you can get back to a normal life completely free of any discomfort or pain that comes with Peripheral Neuropathy.

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Published Clinical Citations



  • Hello, guest
  • recently diagnosed with peripheral neuropathy after several years of not having a clear diagnosis. The hospital where I was diagnosed oofering me a treatment plan with surgery and rehab which they claim is my best chance to stop the progression. I have a friend who tried stem cells and had good success so im willing to try. how much is the treatment cost ? what does the treatment plan includes chord stem cell therapy or fat? does it come with rehab training. Any information would be greatly appreciated.
    • Support Team
      Hello Mr Joseph, thank you for contacting us about treatment for peripheral neuropathy at the Regeneration Center. Please note that our therapy will require travel to Bangkok Thailand. We have emailed you the information that you requested.
  • Hi i had a fue hair implant which went wrong and injured my occipital and trigeminal nerve with needle by the nurse , i jave pain would stem cells helpMe relife from this constant pain  
    • Support Team
      Hello Mr Ibo, Thank you for contacting the Regeneration Center. Based on the information provided you would not be a good candidate for treatment and have emailed you more information to try to better assist.
  • Dear Sir/mamI am Deon from South Africa. I need contact from a representative on stemcel treatment .
  • How many injections of stem cells are given and how many times per week. Do you use stem cells from placental tissue or harvested from the patient's own blood or fat?
  • Diabetic PN for about 7 years now after being diagnosed with diabetes mellitus. Have been taking 150 mg of Lyrica twice a day for pain allevation. A recent heart attack with CABG surgery last Nov 16 2016. 57 years old. Hypertensive as well. Interested to know if I am a good candidate for stem cell therapy. Please provide the costs to involve the following factors. TX cost, TX frequency and duration, side effects, hospital stay in or out patient, cash or credit? Available appointment time and date. Thank you!
  • 58 year old male. Insulin dependent diabetic for 28 years. Suffering from diabetes diabetic neuropathy erectile dysfunction. Are there any therapies for these. What is the duration & cost Do you also undertake umbilical cord harvesting of stem cell for treatment
  • Suffer from peripheral neoropathy severe pain feet none diabetic have tried everything looking at stemcel treatment
  • DEarr Sirs, I world like to have moré información about the the treatment. DOyouhave información in S panish
  • I’ve been told that my idiopathic peripheral neuropathy condition is not curable for 10 years. This gives me hope but I need to know if i would qualify. Please contact me.
  • Can stems cells be effective in treating periferal herpetic neuropathy(PHN); unreseolve in Right shoulder/neck for seven to eight years?
  • Diagnosed with idiopathic small finber neuropathy Oct 3, 2016. ymtpoms started April 15, 2016. appears as if progressing to large fiber. Have not received a diagnosis on large fiber yet.
  • I've been told that my peripheral neuropathy condition is not curable. This gives me hope but I need to know if i would qualify. Please contact me.