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Neural Stem Cell Treatment for Spinal Cord Injuries (SCI)

UPDATED September 21, 2020 – Spinal cord injuries occur in many ways, such as a traumatic accident or hit to the spine that results in a fracture of the vertebrae. The actual damage begins on impact when displaced bone fragments and/or ligaments tear into or bruise spinal tissue. Most spine injuries do not completely sever the spine cause enough damage to cause fractures that can disable or destroy the axons. As the signal carriers of the human body, Axons carry the electric signals and act as a messenger between the body and the brain. Most spinal injuries usually cause damage to some or all of the axons.

What is an Acute Spinal Cord Injury?

The spinal cord is a thick bundle of nerves that is designed to carry signals between our brain and the rest of our body. Acute spine injuries usually occur after sudden & traumatic injury. The SCI can be as minor as a contusion (bruise), a partial tear, or a complete spinal tear (transection). Spinal injures are also more common in young adults and men.

A traumatic spinal injury can result in an instant loss of movement, touch feelings, and reduction in organ function below the damaged vertebrae. The most common areas of spinal injuries are in the cervical ( neck ) and thoracic spine areas. Spinal injuries are one of the most common causes of permanent disability and death in both children and adults.

The human spine consists of 33 vertebrae in total including:

  • 7 in the cervical spine (neck)
  • 12 in the thoracic spine (upper back)
  • 5 in the lumbar spine (lower back)
  • 5 in the sacral area (sacrum, is located in the pelvis area)
  • 4 in the coccygeal (the coccyx is also located in the pelvis area)

These 33 vertebrae help to form our spine and also to protect the spinal cord and nerve bundles. Generally speaking, the higher the spine injury, the more severe the patient’s symptoms are. Injuries to the vertebrae do not necessarily mean the spinal cord is damaged and damage to the spinal column can occur without dislocations or breaks in the vertebrae.

1 Year After Stem Cell Therapy for Spinal Cord Injury

Spinal injuries are usually classified into two main categories:

  • Complete Injuries are indicated by a total loss of sensory or motor functions below the point of Injury.
  • Incomplete Injury is when the person can still relay some messages but in a limited capacity.

Survivors of SCI from sports-related injuries also start suffering for other medical complications such as chronic pain or bowel and bladder dysfunction with increased susceptibility to having heart or respiratory problems. The success of any cellular treatment depends entirely on how well our doctors can manage the systematic failures and chronic conditions through targeted regeneration therapy.

Using Stem Cell Therapy for Injured Spinal Cord

Stem-cell-treatment-of-Spinal-Cord-InjuryCell Therapy for Spinal Cord Injuries focuses on the regeneration of Axons between your brain and body that have been severely limited or non-existent after your accident. Our Stem cell transplants for spinal cord injury helps patients eliminate pain, regain bladder and bowel function, regain lost sensations, and regenerate visceral motor neurons while minimizing other issues such as cramps or depression from Injury. Conventional treatments do not address regeneration and focus on pain management, rehab, and the reduction of secondary damage.

Cell-based treatments take a more proactive approach and look to boost the humans’ natural repair cycle by stimulating/enhancing the repair of damaged cells and tissue. Repairing injured spinal cord requires going beyond any traditional techniques to help you regain some/all of the lost functions. Clinical trials have shown that cell turnover and death is very normal and occurs naturally when the body’s cells are injured or aged. These dead cells are usually surrounded by healthy and damaged cells. Our treatment protocol for Sciatica and spinal transection helps boost the healing of these dead or injured cells through targeted cytokine therapy that makes uses nerve growth factors and paracrine signaling to trick the body into restarting the healing process.

Treating C5 Spinal Cord Injury with Multi-Vector Cell Delivery

Repairing (SCI) Spinal Cord Injury Damage

The Regen center has a unique combination protocol for the treatment of neurological & spinal cord injuries using a multi-step approach. Once our medical team has reviewed the patient current medical condition and determined the appropriate course of action, a detailed plan will be provided. If the patient does not have the quality or quantity of enhanced mesenchymal stem cells needed, cord tissue-derived MSC+ cells will be needed. These cells can be stored using our cryopreservation facility for over 20 years if needed.

TREATMENT PRECAUTIONS & RISKS
MSC+ mesenchymal stem cells treatment for spinal cord injuries is not appropriate for all cases. Patients with complete injuries, unidentifiable tissue damage, travel restrictions, or severe structural problems may not qualify for treatment.

For severe cases with extensive nerve cell atrophy treatments will require expanded MSC+ mesenchymal stem cells and nerve cell growth factors get injected near the damaged spinal areas via a CT-guided intra-spinal machine. The MSC+ protocol for spinal cord injuries is unique as it is the only treatment in the world that offers supplemental injections with nerve cell-specific growth factors to enhance recovery further using lumbar punctures, Intrathecal injections or IV drip injections depending on the severity of the patients’ injuries or if paralyzed.

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Enhanced MSC+ stem cell injections are the platinum standard in modern regenerative medicine especially when dealing with transection of the spinal cord. The precision of cellular guidance allows our team to aim directly adjacent areas of lesions or injury. MSC+ enhanced spinal treatment does not require dangerous open spine surgeries. MSC+ stem cell injections and neural progenitor cells infusions also help patients avoid the risks and pain of additional surgeries associated with traditional treatments for injured spinal cord.[1]

Stem Cell Treatment for Spinal Cords – Protocol Overview

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Treatment Objective and Expected Outcomes

The objectives of our spinal injury treatment center is to help repair damage in a natural and safe manner. Our treatments take place on the cellular level and only affect the areas near to the point of impact. Positive results can be pretty dramatic if the injury is less than 2 years ago. For those with older injuries, traumatic brain injuries, severely degenerative spinal discs, osteonecrosis, peripheral neuropathy or spinal muscular atrophy the chances of full recovery become significantly more difficult with passing time. Newer injuries to tissue, cartilage or ligaments respond much better to stem cell treatments. The recovery after treatment will require a lot of dedication and rehabilitation sessions. Physical improvements are noticeable around 2-3 months after the initial treatment and the results are permanent.[2]

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Benefits of Mesenchymal Stem Cells & Neural Progenitor Cells

  • Eliminate chronic cramps & pain
  • Increased range of motion
  • Control bladder and bowel movement
  • Spastic
  • Reduce muscle tension
  • Improved overall blood circulation “Angiogenesis”
  • Slowed muscle atrophy
  • Improved Orthostatic Hypotension
  • Improved motor functions
  • Increased sexual functions
  • Increase muscle strength
  • Normal perspiration
  • Normal skin temperature

Spinal Injury Treatment Risks & Precautions:

  • Young adults and children respond much better to Enhanced stem cell treatments. Patients from their early 30s to late 70’s have also tested better after stem cells.
  • Injuries at or near the cervical area respond better to treatment, most likely due to better blood circulation.
  • Incomplete SCI have higher success rates than complete injuries.
  • Early stages (6 months to 2-year-old) injuries generally will have much better results than injuries over two years old traditionally do not respond well.[3]

Cost of Spinal Stem Cell Treatment

Treatment prices and costs at our stem cell treatment center for spinal damage depends on the severity of the Injury and protocol needed. The treatment requires a minimum of 14-30 days in Thailand. To qualify for a spinal treatment protocol and receive a complimentary treatment plan with fixed prices, our doctors will need to understand the needs via recent MRIs, CT-Scans, and clinical diagnosis from your primary care physician or home country. The final plan and medical costs will include all hospital fees, rehabilitation costs, doctors fees, lab work, stem cell collection, and cell expansion costs. mesenchymal stem cell banking is also available at an additional cost. Short-term apartment options are also available for patients and families. Residents of Canada, the United Kingdom, Australia & the United States may qualify for medical financing. Please contact us for more details.

To learn more about our combination MSC+ stem cell therapy for acute spinal cord injuries, please contact us.

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Published Clinical Citations

  • [1] ^ Amr, Sherif M, Ashraf Gouda, Wael T Koptan, Ahmad A Galal, Dina Sabry Abdel-Fattah, Laila A Rashed, Hazem M Atta, and Mohammad T Abdel-Aziz. 2013. Bridging defects in chronic spinal cord injury using peripheral nerve grafts combined with a chitosan-laminin scaffold and enhancing regeneration through them by co-transplantation with bone-marrow-derived mesenchymal stem cells: case series of 14 patients. The journal of spinal cord medicine, no. 1 (November 26). doi:10.1179/2045772312Y.0000000069. https://www.ncbi.nlm.nih.gov/pubmed/24090088

  • [2] ^ Dajpratham, Piyapat, and Racharin Kongkasuwan. 2011. Quality of life among the traumatic spinal cord injured patients. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, no. 10. https://www.ncbi.nlm.nih.gov/pubmed/22145512

  • [3] ^ Piltti, Katja M, Desiree L Salazar, Nobuko Uchida, Brian J Cummings, and Aileen J Anderson. 2013. Safety of human neural stem cell transplantation in chronic spinal cord injury. Stem cells translational medicine, no. 12 (November 4). doi:10.5966/sctm.2013-0064. https://www.ncbi.nlm.nih.gov/pubmed/24191264