In the unfortunate event, you or perhaps a family member are coping with diabetes you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are usually not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. A number of other individuals have no symptoms at all.
Understanding Hyperglycemia
As time goes by, however, the effects of both kinds of diabetes become increasingly serious and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage, and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. According to recent research, some of the oral diabetes medications can also help contribute to heart malfunction.[1] That is exactly why it’s important that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger the more harmful, degenerative ailments. The regeneration center can help treat DM with our innovative enriched and expanded Mesenchymal cells treatment for Diabetes safely and without any artificial medicines or need for regular insulin dependency.[2]
Damage to Insulin Producing Beta-Cells
Stem Cell treatments for diabetes and functional medicine look to fight the disease at its origins in the pancreas. Decreasing hyperglycemia as well as associated complications (see above).
According to recent research, it can also relieve hypoglycemia or low level of blood sugar, which consequently can also lead to fatality if it is not treated immediately. Diabetic patients are treated by introducing enhanced MSC+ cells to the pancreatic area via IV or directly (severe cases). Diabetes is a metabolic disease with a significant inflammatory component wherein the individual has elevated level of blood sugar, because the human body cannot generate enough insulin, or maybe because the cells are no longer responding to the insulin produced naturally by the body. The high blood sugar levels instigate signs of polyuria or recurrent peeing, polydipsia or abnormal increase in thirst, and polyphagia,pancreatic cancer, pancreatitis or the state of increased hunger and in severe cases lupus disease.[3]
3 Types of Diabetes Mellitus:
Type 1 vs Type 2 Diabetes
Type 2 diabetes: results from insulin resistance, a condition wherein cells are not able to use insulin appropriately, sometimes coupled with a complete insulin deficiency requiring insulin pumps. – Type 2 is often an acquired disease and if caught early is a very treatable condition at the regeneration center. Long-term risks of having diabetes include acute transverse myelitis, retinopathy (loss of vision), diabetic nephropathy which leads to kidney failure, peripheral neuropathy ( foot ulcers that lead to amputations or Charcot joints ), and autonomic neuropathy that causes genitourinary, gastrointestinal, cardiovascular symptoms with sexual dysfunction. Patients diagnosed with diabetes also report increased occurrences of peripheral arterial disease (PAD), atherosclerotic cardiovascular disease and cerebrovascular disease. Other complications include hypertension and severe abnormalities of lipoprotein metabolism. Many patients can also impair beta cell insulin secretion because of pharmaceutical medications they are taking. These medications do not directly cause diabetes, but they may lead individuals to become insulin resistant. Learn more about foods that fight inflammation
Gestational Diabetes is when pregnant women, who’ve never had diabetes before, have a high blood glucose level while being pregnant. It may precede the development of type 2 DM.- We cannot treat Gestational diabetes with stem cell therapy.
- FPG, fasting plasma glucose
- HNF, hepatocyte nuclear factor
- GAD, glutamic acid decarboxylase
- GDM, gestational diabetes
- GCT, a glucose challenge test
- IFG, impaired fasting glucose
- MODY, maturity-onset diabetes (young)
- IGT impaired glucose tolerance
Prevention of Diabetes
DNA editing is still in clinical trials so currently type 1 diabetes cannot be prevented but can be identified early using dna testing. Understanding the potential risk factors and environmental triggers are proactive measures that help delay/avoid destruction of the friendly insulin-producing cells in the body. There several known factors that can influence and expedite the development of diabetes type 2. Its clearly evident that lifestyle behaviors are the most influential factors. These lifestyle choices include frequent consumption of junk foods or inactive sedentary lifestyle. Research from across the world have already established that changing your lifestyle to include physical activities and healthy diets can prevent onset type 2 diabetes.
The Regeneration Center recommendations for a healthy diet
- Eating at least two-three servings of vegetable every day (including green leafy vegetables)
- Choose water, tea or coffee over fruit juices, sodas or other sweetened beverages
- Use whole-grains for bread, rice, or pasta instead of processed white breads, rice, or pasta
- Choose natural peanut butter over chocolate spreads or jam
- Eat lean cuts of white meat,seafood or poultry instead of red meat & processed meat
- Eat nuts, fresh fruit, or unsweetened yogurts as a snack
- Eliminate tobacco and limit alcoholic intake to a maximum of one per day
- Eating up to three servings of fresh fruit every day
Modern lifestyles across the developed world are characterized by long sedentary periods, bad diets and inactivity. To help prevent diabetes the Regeneration center recommends frequent physical activity for a minimum of 15-30 minutes each time. Taking a holistic approach to disease prevention is critical for reducing the risk type 2 diabetes and its deadly complications. While these changes might be easier to implement early in life, healthy lifestyles can instantly boost quality of life with health outcomes at later stages in life.
Stem Cell Treatment for Diabetics
MSC+ Beta Stem Cells for Type 2
At this stage, cures for Type 1 diabetes or gestational diabetes are very very low probability. There is a genetic component of the disease that will require gene therapy to reprogram the cells from reverting back to their compromised states however these solutions are just in the clinical trials stage and have not been approved for clinical applications. According to the international diabetes federation, Type 2 Diabetes T2D however is usually treatable and reversible if caught early enough before it starts affecting the immune system and other organs/systems in the body. Often time, patients simply ignore the disease and try to manage the symptoms using traditional diabetes medication (Metformin, Thiazolidinediones, DPP-4 inhibitors, Meglitinides), change of diet and/or regular insulin therapy to manage blood glucose levels. If metabolic diseases are left untreated, complications often occur and can include:
- Foot Complications / Ulcers
- SpA Spondyloarthritides Disorders
- Kidney Failure (Nephropathy) and PKD
- Ketones & DKA (Ketoacidosis)
- Ulcerative colitis and Crohn’s disease – IBD
- High Blood Pressure & Hypertension ( leads to heart disease, eye problems )
- Brain Strokes
- HHNS – Hyperosmolar Hyperglycemic Nonketotic Syndrome
- Pancreas Cancer
- Damage to insulin producing cells requiring insulin pumps
- Gastroparesis
TREATMENT PRECAUTIONS & RISKS
Please note patients with multiple comorbidities or immune system dysregulation may have travel restrictions in travel to Thailand. All potential candidates seeking stem cells for diabetes must be approved in advance using current medical records and recent blood panels that include: HbA1C, fasting plasma glucose (FPG), oral glucose tolerance test (OGTT), blood pressure and lipid profiles. Please contact us for more information about a permanent treatment for diabetes.Treat Diabetes with Functioning Beta Cell Transplants
Cell lineages and quantities will depend on the patient’s medical needs, Diabetics are most often treated by isolated and expanded MSC+ Cells along with ductal epithelial cells, β-cells & pancreatic islet-like cells. Older patients or severe cases with multiple underlying conditions will require enhanced allogeneic stem cells (Cord tissue derived w/ anti-HLA antibodies) that are differentiated into glucose-sensing, insulin-producing beta cells.[5]
Diabetes Stem Cell Treatment Guidelines – 2023
Total number of stem cell infusions will depend on patient needs but will include MSC+ Mesenchymal stem cells, pancreatic progenitor cells and β-cells of the pancreas (insulin producing beta cells).
Type of Injections: Pancreatic endocrine cells differentiated to beta cells and pancreatic progenitor cells that are delivered to the patient via IV Drip or combination of sequential Intrathecal injections.
Rehabilitation Treatment : (Optional) Rehabilitation therapy (2 hours per day and 5 days per week) medical visas and accommodations for an extended stay can also be included at an additional cost. Total treatment period: 2 – 3 weeks
Treating T1DM & T2DM With Stem Cells
The cellular treatment for Diabetics and neogenesis of β-cells & pancreatic islets will require a minimum of 14 days in Bangkok. The costs for treating Diabetes with MSC+ cells will depend on many factors including current health and the existence of any other underlying medical conditions. To better prepare our medical team will need to be review patients’ relevant medical information, genetic tests for risk variants found in diabetes (if available) and recent blood tests. Upon approval, a customized treatment plan will be provided that includes all medical related costs including stem cell extractions, expansion. Stem cell therapy for diabetes success rates depend on stage and severity, To learn more about the treatment of Onset DM using Adult stem cells please contact us today.
Published Clinical Citations
[1]^ Kao, Der-I, and Shuibing Chen. 2012. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes. Regenerative medicine, no. 4. doi:10.2217/rme.12.27. https://www.ncbi.nlm.nih.gov/pubmed/22817630
[2]^ Sacks, Frank M, Michel P Hermans, Paola Fioretto, Paul Valensi, Timothy Davis, Edward Horton, Christoph Wanner, et al. 2013. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, no. 9 (December 18). doi:10.1161/CIRCULATIONAHA.113.002529. https://www.ncbi.nlm.nih.gov/pubmed/24352521
[3]^ Sacks, Frank M, Michel P Hermans, Paola Fioretto, Paul Valensi, Timothy Davis, Edward Horton, Christoph Wanner, et al. 2013. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, no. 9 (December 18). doi:10.1161/CIRCULATIONAHA.113.002529. https://www.ncbi.nlm.nih.gov/pubmed/24352521
[4]^ Sukpat, Supakanda, Nipan Isarasena, Jutamas Wongphoom, and Suthiluk Patumraj. 2013. Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress. BioMed research international (June 17). doi:10.1155/2013/459196. https://www.ncbi.nlm.nih.gov/pubmed/23844362
[5]^ Zhao, Yong, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, et al. 2013. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. BMC medicine (July 9). doi:10.1186/1741-7015-11-160. https://www.ncbi.nlm.nih.gov/pubmed/23837842