new-lung-scarring-treatment-stemcells-ipf

Treat Lung Scarring w/ Stem Cell Therapy for Pulmonary Fibrosis – IPF ILD

Updated June 25, 2019 – Pulmonary fibrosis is the thickening and scarring of the lung tissue. The term idiopathic denotes the cause is unknown and occurred spontaneously. Though it is not completely understood what causes idiopathic pulmonary fibrosis, the disease process is well-explained in various medical literature and case history.(25039426)

Healthy vs. Diseased Lungs

 Interstitial Pulmonary Fibrosis

Diffuse parenchymal lung disease (DPLD) & Interstitial lung disease (ILD) are a group of lung diseases that affect the tissue and spaces around the air sacs (interstitium) in the lungs (alveoli). This family of various lung disorders occurs an injury to the lungs that fails to heal properly for various reasons. Areas of the lungs that are prone to injuries include:

  • Pulmonary capillary endothelium
  • Basement membrane – a specialized form of extracellular matrix (ECM) 
  • Alveolar epithelium – functional & physical barrier of dangerous environmental agents
  • Perilymphatic lung tissue
  • Perivascular tissue

Alveolar Fibrosis – Fibroid Lung Disease

Under normal circumstances, the human body can initiate self-repair of the lungs using paracrine cell signaling but for some patients with interstitial lung disease, this normal lung repair process malfunctions resulting in the tissue around alveoli air sacs to thicken and become scarred. Thickened scarred lung tissue makes it difficult for oxygen to pass back into the bloodstream resulting in damage to both the entire cardiovascular system and lungs. The term Interstitial lung disease is used by pulmonologists to distinguish these types of lung diseases from others such as COPD and obstructive airways diseases. If left untreated, Interstitial lung disease results in fibrotic scarring of the lungs known as pulmonary fibrosis. Idiopathic pulmonary fibrosis usually gets diagnosed after radiographic lung scans start to show pleural-based fibrosis with honeycombing in the lungs and proliferating fibroblasts (fibroblastic foci.)

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IPF and fibroid lung disease usually starts with a presence of inflammation in the alveoli. The alveoli are the tiny air sacs in the lungs where the exchange of carbon dioxide and oxygen happens. The fragile lining of the alveoli allows this gas exchange. Once these alveoli become inflamed and damaged in some way, the body’s reaction would be to activate the immune response and to heal the damaged alveoli.(25986617)

This causes scarring and thickening of the alveolar walls. Unfortunately, the thickened and scarred alveoli cannot perform efficiently during gas exchange. This ultimately leads to a lesser amount of oxygen that can be transported into the body and less carbon dioxide that can be expelled out.

Signs & Symptoms of Pulmonary Fibrosislung-diseases

Some of the common signs and symptoms that are present in patients diagnosed with onset idiopathic pulmonary fibrosis are:

  • Severe shortness of breath. This is caused by heart disease or the decreased amount of oxygen that the body gets due to the inefficient, affected alveoli. It gets worse with physical activity since the body is trying to get more oxygen.
  • Constant Dry cough.
  • Clubbing sensations of the finger and toenails. Clubbing is the swelling in the base of the finger and usually accompanied by cyanosis (bluish discoloration of the nails.) This is a sign of hypoxia or decreased level of oxygen in the tissue. This sign often manifests later on the disease progress and end-stage pulmonary fibrosis.
  • Reduction of lung capacity or airflow obstructions resulting in premature fatigue

 Lung Scarring  – ILD & IPF

Since the underlying cause of Idiopathic lung fibrosis is often unknown, patients usually wonder how they get fibrotic scarring of the lungs. For most patients, the most common predisposing factors of developing interstitial pulmonary disease & alveolar fibrosis are:

  • Cigarette smoking is a common cause of interstitial pulmonary fibrosis
  • Reaction to drugs or medications such as antibiotics, chemotherapy drugs & cardiac dysrhythmia medications (antiarrhythmic)
  • Genetic – Familial fibrotic scarring of the lungs
  • Exposure to various inorganic toxins, chemicals, and pollutants such as asbestos, beryllium (berylliosis), crystalline silica dust (silicosis)
  • Exposure to organic compounds, dust, fungus or mold (hypersensitivity pneumonitis)
  • Viral infections such as pneumocystis pneumonia (PCP), tuberculosis, atypical pneumonia, chlamydia trachomatis & syncytial virus
  • GERD (Gastroesophageal reflux disease). This is when the stomach contents of a patient go back to the esophagus. There is a risk of aspiration of these stomach contents into the trachea, which can in turn cause lung infection.(26593230)
  • Connective Tissue Disorders & autoimmune response due to conditions such as Lupus, rheumatoid arthritis, polymyositis, dermatomyositis, lymphangitic carcinomatosis, antisynthetase syndrome (inflammation) and systemic sclerosis
  • Inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease
  • Idiopathic (non-identifiable)i.e. acute interstitial pneumonia (Hamman-Rich syndrome),Idiopathic pulmonary fibrosis & sarcoidosis

Diagnosing Pulmonary Fibrosis

The diagnosis of interstitial lung diseases and pulmonary fibrosis requires diagnostic tests and physical exams. A pulmonologist uses several diagnostic tools to understand the signs & better

Idiopathic-Pulmonary-Fibrosis-treatment-thailand-lung-xrays

Symptoms of patients with interstitial lung disease. Depending on the stage and severity of a patients condition lung specialists typically order the following tests:

  • Pulmonary function tests for measuring decreased diffusion capacity (DLCO) to see if any restrictions exist
  • Lung radiology scans using X-ray or High-Resolution Chest CT-Scans (HRCT) to check for patterns of opacities in lung tissue that are caused by the thickened and scarred lung tissues.
  • An arterial blood test can be taken for examining the ability of the lungs to move oxygen into the tissues of the body.
  • Lung biopsy: getting a sample of lung tissue and studying the sample to better identify areas of scarring or thickening or suggestive of any malignancy. Biopsies can include a trans-bronchial biopsy or the more invasive surgical lung biopsy.
  • Genetic testing for pulmonary fibrosis and Cystic Fibrosis – May prevent the need for surgical lung biopsy

Screening for Mutations that may cause Familial Pulmonary Fibrosis

The Lung Regeneration center offers a comprehensive list of genetic screening tests for checking mutations in genes that lead to familial lung diseases. Tests for the following genes are currently available to screen for congenital autosomal recessive & autosomal dominant interstitial lung diseases:

ABCA3, FLCN, SFTPB, SFTPC,CSFR2A, CSFR2B, COPA,TSC1, TTF1, TSC2, DOCK8, STAT3, FoxF1, PGM3, SPINK5, METRS, MRS, MTRNS, CMT2U, ILFS2, ILLD, mENA, NISBD2, RTEL1, PIG61, ERBB, ERBB1, HER1, SPG70, TERC, TERT & PARN

Genetic tests are recommended for family members of patients who have already been diagnosed with. There are currently no available gene therapies to treat autosomal interstitial lung diseases, but there are several clinical trials underway with the hopes of one-day curing genetic lung diseases. To help reduce any risk of developing fibroid lung disease, ILD or Pulmonary fibrosis consider including pulmonary tests as part of your annual checkup, refraining from smoking and getting regular exercise to keep the lungs and heart as healthy as possible.

Traditional vs. Modern Treatments for ILD & Lung Fibrosisalvioli-restoration-stem-cells-Idiopathic-Pulmonary-Fibrosis-stem-cells-regen

In the past, there were traditionally minimal options for treating chronic progressive lung diseases such as COPD and idiopathic pulmonary fibrosis. Even today, there are several clinical trials for trying to cure interstitial lung diseases, familial pulmonary fibrosis and idiopathic lung sclerosis using modified gene therapies but as of today, there are no effective pharmaceutical medication based cures approved for treatments.  In some cases, steroids are prescribed to help decrease the inflammation or mucomyst (Acetylcysteine) to reduce symptoms, but the effects are temporary and do nothing to the underlying cause of the disease. Lung transplants are another option for some but are considered very invasive, high-risk, and are usually only offered to advanced end-stage pulmonary fibrosis patients. Although it has its limitations, modified MSC+ lung stem cells offer a natural alternative to lung transplants for pulmonary fibrosis and anti-fibrotic medications.(25412619)

Treatment for Lung Fibrosis with Stem Cells

Stop Hardening of Lung Disease & Alveolar Fibrosis Naturally

Your Stem cells are essentially the bodies pharmacy. Stem cells are are the building blocks of your entire body. These types of potent cells are called “totipotent” cells as they can change/differentiate into any cell, tissue, or bone in the human body. When used properly, MSC+ Stem Cells can help with the loss of lung capacity/reduced lung function by focusing on the destroyed or limited linings of the alveoli that are at the root of the disease. (25896401) For various reasons (Cigarette smoking, Viral infections, genetics) the bodies natural ability to regenerate is being blocked causing the types of complications that manifest themselves as fibrosis and lung hardening disease.

after-lung-stem-cell-treatment-thailand

The Regen Center treatment for IPF lung sclerosis uses isolated & enhanced lung stem cells seeks to re-promote natural healing of the previously damaged alveoli cells, fibrotic scarring in interstitium lining of the lungs and scar tissue in lungs from pneumonia. The goal of the enhanced MSC+ stem cell treatment for pulmonary fibrosis and lung hardening disease is to assist the body in bypassing fibrotic scarring by regenerating new healthy tissues and blood vessels through a process called angiogenesis. The new lung regeneration treatment offers a safe, natural alternative to lung transplants by regeneration of lung tissue affected by fibrotic scarring and honeycombing through increased levels of myofibroblasts.

TREATMENT PRECAUTIONS & RISKS
Please Note That Stem Cell Treatments for IPF and Chronic Lung Diseases are not appropriate for all patients. Those with multiple conditions, late stage, or travel restrictions due to the need for constant Oxygen tanks may not qualify for the 2-3 week treatment protocol. Please contact us for details.

Idiopathic-Pulmonary-Fibrosis-results-bangkok-stemcells-thailand

Multi-Stage Lung Cell Delivery for Respiratory Diseases

Interstitial lung diseases & progressive pulmonary fibrosis pose a significant challenge for pulmonologists and lung bioengineering. Diseases such as asthma, popcorn lungs “Bronchiolitis obliterans,” Idiopathic pulmonary fibrosis, lung cancer treatment, COPD, idiopathic interstitial pneumonia, Cystic fibrosis, emphysema & hyaline membrane disease are just some of the diseases that can be managed effectively via lung stem cell therapies. Due to the complexity and locations of the diseased regions, it can be challenging to effectively deliver cell therapeutic agents to the needed regions of the diseased lungs. The Regeneration Center has developed a unique popcorn lung treatment protocol using combination of cell delivery methods to target the diseases from multiple vectors including guided radiography (when necessary), Intravenous, direct injection, Intrathecally and now for the first time via Intranasal inhalation for a painless and effective delivery of endogenous lung progenitor cells, lung epithelial stem cells to both the airway and vascular system of the lungs.

MULTI-VECTOR LUNG CELL DELIVERY

The Regeneration Center has developed a combination delivery method to target the diseases from multiple vectors (depending on the patient’s needs) including guided radiography (when necessary), Intravenous, direct injection, Intrathecally and now for the first time via Intranasal inhalation stem cell therapy for a painless and effective delivery of endogenous lung progenitor cells, Lung epithelial stem cells to both the airway and vascular components of the lungs.

 Guidelines for Treating Chronic Pulmonary Fibrosis


Total of MSC+ Stem Cell Infusions will depend on the severity of restrictive lung disease, and multiple stages may be necessary for patients with scarring in interstitium of lung or diffuse parenchymal diagnosis. For optimal results, multiple methods of cell delivery will be required. Due to the progressively degenerative nature of restrictive lung diseases, most patients will require enhanced cell transplants derived from immune-compatible cells.  For patients with multiple simultaneous issues, extensive honeycombing or severe respiratory failure, multiple treatments may be required. The isolated and expanded MSC+ lung cells used are pre-screened for infectious diseases, sterility, and potency. For patients with severe respiratory failure, aggressive combination treatment may be required.

Treatment Requirements & Lung Rehabilitation

Post-Treatment Lung Rehabilitation: Pulmonary Rehabilitation Services is optional but is highly recommended after any treatment. For patients with the option to stay in Thailand, we offer a complete integrative rehabilitation program in partnership with local hospitals in Bangkok. Pulmonary rehabilitation is also beneficial for patients who are experiencing severe difficulty in breathing or severe hardening of the lungs. Smoking is also much discouraged for patients with this condition, and active smokers will not qualify for our treatment.  The rehabilitation packages in Bangkok are available to all candidates as needed (2-5 hours per day, six days per week)
. Medical treatment visas and hotel accommodations for long term stays can also be provided upon request.

Due to varying degrees of respiratory diseases, our pulmonary specialists will need to understand better the patients needs to qualify any potential candidates. Our initial review can be done online and takes around 7-9 business days for the medical assessment. Suitable candidates looking to reverse lung scarring naturally using Stem Cells will require a minimum of 2-3 weeks in Thailand. To begin the qualification process, please prepare your recent pulmonary tests such as spirometry exams, lung function tests, and radiology scans from an MRI or (HRCT) High-Resolution Chest Scans and contacts us today.

Request Evaluation

Published Clinical Citations

TREATMENT RELATED QUESTIONS

29 comments

  • Hello, guest
  • Interested in information for my fiance who has a diagnosis of IPF versus allergic alveolitis. Please send me more information on the stem cell therapy, costs, length of treatment, etc. 
  • Hi, My in-law was recently diagnosed as (idiopathic?) pulmonary fibrosis. She is 80 years old. Could you give me some information about the costs for stem cell treatment, accommodations, food, rehab in the local hospital, etc. for the extended stay required to complete the entire treatment and rehab course? Thank you. 
  • My Father is 80 years old and just diagnosed with IPF.  He has always been VERY active.  I would like more info on stem cell treatment at your clinic.  What is the cost?  How long will the stay be generally?
  • I have been diagnosed with Idiopathic Pulmonary Fibrosis in July 2018, they gave me 12 months and I would like to find out about receiving stem cell treatment at your clinic.Costs ETC
  • Hello, my mother is diagnosed with ILD(ANA/anti RO+)@ CKD having trouble in breathing and lower oxygen levels while on routine household activities. I would like to know if you can help on any available treatment for her. And what would be the approximate time of treatment and cost. Thank you.
    • Support Team
      Hello Mr Kharpude, Thank you for contacting the Regen Center. We have emailed you more information about treatment options for your mothers interstitial lung disease.
  • Hello, I would like to have more information from pulmonary fibrosis, my father is in the begin of this disease, I will like to know if you have some treatment. Thank you
    • Support Team
      Hello Mr Castillo, Thank you for contacting us about your treatment for your fathers lung disease (pulmonary fibrosis) . An email was sent to you with the information requested.
  • How much does this lung disease treatment cost? My dad was diagnosed with IPF about a year ago. He  is 68 yrs old. 
  • Hi, my father have been diagnosed with Idiopathic Pulmonary Fibrosis and would like to find out about receiving stem cell treatment at your clinic. Do you collaborate with a hospital in Greek or a Greek doctor? Thank you in advance for your reply.
    • Support Team
      Hello Mrs Ioanna, sorry we do not have a treatment in Greece or have Doctors who speak Greek. We can offer assistance in English and Thai only.
  • I have been diagnosed with Idiopathic Pulmonary Fibrosis and would like to find out about receiving stem cell treatment at your clinic.
  • Hi, i am a 40yr old from New Zealand and i have A1ATD, I was a smoker and have now stopped, but alas damage was already done. At the moment i struggle to walk more then 40M without running out of air. I am wondering if you are able to help get my lung function better. I was a very active person before my lings gave out, I was a martial arts teacher. Cheers
  • My husband has been diagnosed with IPF and has been on oxygen therapy for over a year .Would he qualify for stem cell therapy? He is 84 years old but has always been very active - was still working until 2 years ago .He is desperat to get back to work!Please let me know what other information you require
  • looking to have stem cell therapy for damaged lungs. Dad was diagnosed 2 years ago. recent respiratory test show 80% in one lung and 75% in the other. can send you all tests.Can stem cell therapy cure IPF?
  • Good day.I am Jedd Cruz. My mom is diagnosed with IPF. I understand there is no cure, so am desperate to seek some help. Would you be able to send me additional info on how the arrangement for treatment is done? Thank you.
  • My Brother was just diagnosed with IPF and lung failure. We did tests to make sure and its not genetic but my mother also had Interstitial lung disease. She had a lung transplant back in 2006 and ended up dying from complications from it in 2010. Its a terrifying and terrible disease. We are now exploring alternative treatments and cell therapy is on top of our list. Did want to ask though s there a way to shorten treatment time?
  • Hello, I had an accident in Germany and had a CT scan , The German Dr. found a shadow on my right lung. So when i went back to the USA. I told my doctor to do a new CT scan . The Dr said , Nothing has changed , still a shadow on the right lung. So make sure my lung is clean and clear , sinus too. I do exercise for my lungs . to help stay strong. The Dr says i have Bronchiatasis . So then i read about stem cell research . I went to another Dr in Denver Colorado . He took bone marrow out of my hip , but said it was not good to inject because of little clots.He said my blood clots fast . He tried again and the same happened again . I will see my family Dr . on thursday . I am wondering if you know of a better way to help me. I do not have a cough , I am not out of breath , I exercise , The doctor says it was because i was sick as a child. I do not smoke. But i would like to repair my lung ... it is two little spots on the right lung.
  • hello everybody.......... i was diagnosed of idiopathic pulmonary fibrosis (IPF) 2015 and my 2 medications are not help me slow down the progression of IPF which was pirfenidone and nintedanib,so i chose Pirfenidone helps to slow the development of scarring in the lungs by reducing the activity of the immune system.i spent a lot of money taking this medication and herbal medicine but my condition get worse every month. Can stem cell therapy help repair my lung tissues?
  • Can your treatment help small holes in lungs. I am not a smoker and diagnosed with mild emphysema possible exposure to fungus pulmonary doc says
  • What kind of results have you had with this treatment? Does it reverse the scarring? If the lungs regenerate, does the fibrosis continue?thank you
  • My wife was diagnosed with idiopathic pulmonary fibrosis in January after being sick for over 2 years. Our doctors have told us that the disease in in terminal stage and they believe she has less than 6 months to live. I don't know what to do. We don't have insurance and really need some support and guidance from someone. Our doctors are not being very helpful and have told us that they cannot do anything other than increase her dosage of Nintedanib which has not done anything. Is my wife a candidate for stem cells?
    • Support Team
      Thank you for contacting us about treatment for your wifes condition. Please note terminal stage patients normally require constant supply of oxygen and are severely limited in travelling. It would be best to work with a pulmonary specialists in your home and have emailed you the information requested.
  • Support Team
    My wife was diagnosed with pulmonary fibrosis last year. We went to University in Spain to see some lung specialists but it seems that her lungs are so bad and she also has diabetes type 2 so she did not qualify for the stem cell clinical trials. The doctors there recommended a lung transplant but we really do not want to do that. One of the patients there recommended we contact you to see if there were any option. We will Fax all her records to you next week. Please email us if you need anything more from us.