Updated January 20, 2017 – Pulmonary fibrosis is the thickening and scarring of the lung tissue. The term idiopathic means that the cause of the disease is unknown. Though it is not completely understood what causes idiopathic pulmonary fibrosis, the disease process is well-explained in various medical literature and case history.(25039426)
Treatment of IPF with Stem Cells
IPF disease usually starts with a presence of inflammation in the alveoli. The alveoli are the tiny air sacs in the lungs where the exchange of carbon dioxide and oxygen happens. The very thin lining of the alveoli allows this gas exchange. Once these alveoli become inflamed and damaged in some way, the body’s reaction would be to activate the immune response and to heal the damaged alveoli.(25986617)
This causes scarring and thickening of the alveolar walls. Unfortunately, the thickened and scarred alveoli cannot perform efficiently during gas exchange. This ultimately leads to lesser amount of oxygen that can be transported into the body and less carbon dioxide that can be expelled out.
Primary Risk factors for IPF
the most common predisposing factors of developing idiopathic pulmonary fibrosis are:
- Cigarette smoking
- Exposure to various pollutants
- Viral infections
- GERD (Gastro-esophageal reflux disease). This is when the stomach contents of a patient go back to the esophagus. There is a risk of aspiration of these stomach contents into the trachea which can in turn cause lung infection.(26593230)
- Inflammatory bowel diseases such as ulcerative colitis and crohn’s disease
Signs and symptoms for IPF
Some of the common signs and symptoms that are present in patients diagnosed with onset idiopathic pulmonary fibrosis are:
- Severe shortness of breath. This is caused by the decreased amount of oxygen that the body gets due to the inefficient, affected alveoli. This gets worse with physical activity since the body is trying to get more oxygen.
- Constant Dry cough.
- Clubbing sensations of the finger and toenails. Clubbing is the swelling in the base of the finger. This is usually accompanied by cyanosis which the bluish discoloration of the nails. This is a sign of hypoxia or decreased level of oxygen in the tissue. This sign usually manifests later on the disease progress.
- Easily being fatigued
Traditional vs Modern Treatments for IPF
There were traditionally very limited options for treating a progressive degenerative diseases such as COPD and idiopathic pulmonary fibrosis. No pharmaceutical medication based cures are available to treat this disease today. In some cases, steroids are prescribed to help decrease the inflammation but the effects are temporary and does nothing but mask the illness. Lung transplants are an option for some but are considered very invasive and dangerous in nature. Lung transplants are very risky and is usually only offered in advanced stage patients. The alternative to lung transplants is non-surgical stem cell treatment for Idiopathic Pulmonary Fibrosis.(25412619)
Healthy vs Diseased Lungs
Diagnosing Idiopathic Pulmonary Fibrosis
After going through a thorough physical exam and health history taking, some of the diagnostic procedures that can confirm a diagnosis of pulmonary fibrosis are:
- Chest X-rays or CT Scans: The doctor may see a pattern of opacities in a patient’s X-ray which can be caused by the thickened and scarred lung tissues.
- Pulmonary function test: a test done to measure the patient’s breathing capacity.
- Arterial blood test: to examine the ability of the lungs to move oxygen into the tissues of the body.
- Lung biopsy: getting a sample of lung tissue and studying the sample to identify areas of scarring and thickening.
Stop Lung Disease & Lung Failure
Your Stem cells is essentially the bodies pharmacy. Stem cells are are the building blocks of your entire body. These types of potent cells are called “totipotent” cells as they are able to change/differentiate into any type of cell,tissue or bone in the human body. The stem cell therapy for Idiopathic Pulmonary Fibrosis, focused on the destroyed or limited lining of the alveoli that is at the root of the issue. (25896401) For various reasons (Cigarette smoking,Viral infections,genetics) the bodies natural ability to regenerate is being blocked causing the types of complications that manifest themselves as diseases and degenerations.
Our treatment for IPF using lab enhanced stem cells seeks to re-promote natural healing of the previously damaged alveoli cell and lining. The goal of our stem cell treatment for idiopathic pulmonary fibrosis is to assist the body in regenerating new healthy tissues and/or blood vessels through a process called angiogenesis. Our lung cell treatment offers effective regeneration and replacement of the lung tissue affected by fibrotic scarring and honeycombing through increased levels of myofibroblasts
TREATMENT PRECAUTIONPlease Note That Stem Cell Treatments for IPF and Chronic Lung Diseases are not appropriate for all patients. Those with multiple conditions, late stage or travel restrictions due to need for constant Oxygen tanks may not qualify for the 2-3 week treatment protocol we offer. Please contact us for details.
Guided Cell Delivery using Angiography
Angiography delivery of stem cells are a very precise method of cell delivery using a catheter through the femoral vein. This catheter used in the stem cell treatment for IPG is carefully guided to appropriate areas through our scanners. The arteries and tissues linings being treated using our CD34+ MSC stem cell concentrate requires about 90 minutes in total per treatment with some patients requiring 2-6 timed cell infusions per treatment stage depending on the patients exact needs.
IPF Treatment Protocol
Total of Stem Cell Infusions Required: 2-6 Infusions of Clinical Grade Enriched MSc Cells. ( Multiple stages may be necessary for severe cases )
Method of Cell Delivery: Due to the progressive degenerative nature of the disease, most patients will require Allogeneic cell transplants derived from HLA matched Cord blood, Amniotic Membrane &/or Placenta tissue derived cells. For older patients or patients with severe respiratory failure an aggressive combination treatment will be required. The enhanced cells are screened for Infectious Diseases,Sterility and strength with official documentation of good cellular manufacturing processes at time of treatment. Our Lung regeneration treatment injections are made via a Guided CT Scanner (when necessary) through an Intravenous Drip, Direct injection and/or Intrathecally.
Post-Treatment Lung Rehabilitation: Pulmonary Rehabilitation Services is optional but is highly recommended after any treatment. For patients with the option to stay in Thailand, we offer complete integrative rehabilitation program in partnership with Bangkok Hospital or Bumrungrad international hospital in Bangkok. Pulmonary rehabilitation is also beneficial for patients who are experiencing severe difficulty in breathing. Smoking is also greatly discouraged for patients with this condition and active smokers will not qualify for our treatment. The rehabilitation packages in Bangkok are available to all candidates as needed (2-5 hours per day, 6 days per week) . Medical treatment visas and hotel accommodations for long term stays can also be provided upon request.
Due to varying degrees of respiratory diseases our pulmonary specialists will need to better understand the patients needs to qualify any potential candidates. Our initial review can be done online and takes around 5-7 business days for the medical assessment. Suitable candidates for the our treatment for IPF with Stem Cells will require a minimum of 14-21 nights in Bangkok. To begin the qualification process please prepare your recent medical records such as (MRIs or Chest CT Scans) and contact us today.