UPDATED June 17, 2019 – According to international statistics, chronic liver disease ranks #4 around the world as the top causes of mortality. Once a human liver incurs serious damage, it usually cannot repair itself naturally thus may posing life-threatening risks to the patient. Given this, the only possible treatment options for chronic liver disease was with a dangerous complete liver transplant. Unfortunately there are a lot of risks to consider with liver transplant surgery. (25935633) The risk is mainly attributed to the tendency of rejection of a transplanted organs. Sometime the body detects the transplanted organ as a “foreign object”, or something that has not come from its own body therefore should be destroyed/rejected.
Types of Hepatic Diseases
The liver is a complex and vital organ and there are over a hundred various classifications of liver disease. These most common types of liver disease include:
- Alagille Syndrome is a genetic disorder coolly seen in young children and infants.
- Alcohol-Related Liver Diseases is also known as “drug-induced” or “toxic” liver failure, this disorder is typically due to overconsumption of alcohol or drugs or due to immune reaction to certain medications.
- Alpha-1 Antitrypsin Deficiency is a genetic disorder that can lead to liver disease and/or emphysema lung failure. Patients with Alpha-1 Antitrypsin Deficiency are often misdiagnosed with Asthma
- Autoimmune Hepatitis (AH) is a chronic condition that occurs when a patients own immune system attacks the liver causing it be be constantly inflamed and unable to heal itself naturally. If left untreated (AH) can lead to liver cirrhosis and Hepatic failure.
- Benign Liver Tumors – Some tumors are cancerous (malignant) while others are benign (noncancerous). Noncancerous (benign) liver tumors do not spread in the body, and typically do not pose any serious health threat.
- Biliary Atresia is typically a genetic disorder in new born children affecting the production of bile and the bile ducts. Biliary atresia disease caused the the bile ducts to become blocked and inflamed causing the bile liquid to remain in the liver and leading to scarring (cirrhosis) the liver.
- Budd-chiari syndrome is a rare condition caused by blockage (occlusion) of the hepatic veins. Symptoms of Budd-chiari syndrome include ascites, abdominal pain and liver enlargement.
- Cirrhosis of liver occurs with normal liver tissue gets replaced with non-living scar tissue. This condition is usually a symptom of several other liver diseases.
- Crigler-Najjar Syndrome (CNS) occurs when there is a high level bilirubin (toxin) in the blood (hyperbilirubinemia). Bilirubin is the byproduct of breaking down red blood cells but must be removed from the body through the bile and intestines. High levels of bilirubin in the blood can lead to jaundice and can also travel to the brain and cause brain damage.
- Fascioliasis (Hepatic fascioliasis) is caused by parasitic infection of liver by a liver fluke (Fasciola hepatica)
- Fatty liver disease or hepatic steatosis occurs when triglyceride fat rapidly accumulates in liver cells.
- Non-alcoholic fatty liver disease (NAFLD) is a family of conditions that are usually associated with metabolic syndromes like diabetes 2 or obesity.
- Galactosemia Galactosemia is a genetic disorder that prevents patients from processing the sugar galactose. Rapid accumulation of galactose in the body can result in dangerous complications such as an kidney failure, enlarged liver, brain damage or cataracts in the eyes.
- Gilbert Syndrome a genetic disorder that prevents the liver from processing bilirubin. This condition is more common in men than in women and can cause jaundice.
- Hemochromatosis is a common genetic disorder which causes patients to absorb and store too much iron in the body. The abundance of iron buildup can be very dangerous for several organs, especially the liver and if left untreated can lead to organ failure.
- Hepatic Encephalopathy also known as portosystemic encephalopathy (PSE), is a medical condition that affects the brain function of patients with severe liver disease and the inability to remove toxins from the blood. If these toxins build up they travel throughout the body until they reach the brain resulting in physical and mental dysfunction.
- Hepatitis inflammation of the liver can be caused by several factors including viruses (viral hepatitis), liver toxins, autoimmune response or hereditary conditions.
- Hepatitis A liver disease is caused by the hepatitis A virus (HAV) and causes the liver to get swollen and prevent it from functioning properly.
- Hepatitis B liver disease is usually preventable and caused by the hepatitis B virus (HBV). A Hepatitis B diagnosis can cause the liver to enlarge and prevents proper function. Hep B is treatable and over 95% of adults who are exposed to Hep B recover in 1 year or less. Chronic Hepatitis B is serious and can result in cirrhosis of the liver, liver failure and/or liver cancer.
- Hepatitis C liver disease is caused by the Hepatitis C virus (HCV). Hep C can be autoimmune in nature and causes severe inflammation in the liver which leads to scarring and liver fibrosis. The cellular death of liver cells triggers body to release inflammatory cells in the liver which then leads to hepatomegaly (enlargement of the liver) and also causes the Glisson’s capsule (fibroelastic sheath) around the liver to stretch causing pain.
- Hepatorenal Syndrome (HRS) is a dangerous condition that reduces kidney function in patients with advanced liver disease. Hepatorenal Syndrome common in patients with advanced scarring in the liver and ascites but can also happen in patients with acute liver failure, fulminant hepatic failure or other types of liver diseases.
- Intrahepatic Cholestasis during Pregnancy (ICP) is a condition that affects the flow of bile acids in the liver resulting in the pregnant woman to constantly itch. This complication usually appears in the third trimester, when hormone concentrations are highest.
- Lysosomal Acid Lipase Deficiency (LAL-D) a genetic progressive disorder that restricts a patients ability to produce lysosomal acid lipase enzyme. This vital enzyme is needed by the body to breakdown lipids (fats) and cholesterol. When the lysosomal acid lipase enzyme is deficient or missing, fats begin to accumulate in tissue and organs throughout the body resulting in liver disease along with high levels of LDL bad cholesterol that is linked to cardiovascular diseases.
- Liver cysts are benign but abnormal growths sacs in the liver that are filled with fluid
- Liver Cancer occurs when malignant cells in the liver grow and spread. Any cancer that starts in the Liver is called liver cancer and Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the most common type of liver cancer and if the cancer spreads from the liver to other organs it I known as metastatic liver cancer. When pancreas cancer spreads it typically affects the liver. Other rare types of liver cancer include hemangiosarcoma and angiosarcoma of the liver.
- Primary biliary cirrhosis or Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that causes damage to the intrahepatic bile ducts.
- Primary Sclerosing Cholangitis (PSC) liver disease is a chronic disease that slowly damages the bile ducts and then travels to the small intestine. Patients with PSC suffer form constant inflammation and fibrosis (scarring) of tissue that causes bile accumulatation in the liver until it loses all ability to function properly. PSC advances slowly and liver failure can occur 8-15 years after initial diagnosis. Most patients with people with Primary Sclerosing Cholangitis will need a liver transplant but stem cell therapy for Primary Sclerosing Cholangitis can be effective if applied soon after diagnosis. PSC can also result in bile duct cancer.
- Reye Syndrome can affects all organs in the body but especially harmful to the liver and brain. Reye Syndrome often occurs in children recovering from viral infections, like chicken pox and the flu. Complications of Reye syndrome in the Oliver can include abnormal liver function tests, fatty liver deposits, poor blood clotting and/or total liver failure.
- Wilson Disease is a genetic disorder that causes the patient to retain excess copper deposits in the body and not release copper into bile fluid as it normally should. Copper build up in the blood and liver can lead to damage in the kidneys, eyes and brain. If left untreated, Wilson’s disease can result in severe brain damage, kidney failure, liver failure and death.
Diagnosis & Genetic Testing for Liver Diseases
Blood Tests and radiology scans used to diagnose liver failure include:
Liver Panels & Liver Function Test (LFT),Complete Blood Count Comprehensive Metabolic Panel (CMP),Alpha-1 Antitrypsin, Bilirubin, DCP, AFP Tumor Markers, Albumin, Total Protein, GGT, PT, AMA, AST, ALP, ALT, Copper Test (hepatic copper concentration), Ethanol tests, Overdose Drug Testing, Iron Tests, Hepatitis A Test, Hepatitis B and Hepatitis C Tests.
The regeneration center and its functional medicine department offers a comprehensive list of panels to test for inheritable liver & glycogen storage diseases including the following panels:
ATP7B, SPG70, JAG1, NOTCH2, ILLD, METRS, MRS, FBP1, SLC5A1, SLC2A2, PHKA2 G6PC, GBE1,SLC37A4, PYGL GYS2, PHKB, PHKG2,FBP, FBPase 1 & RpL17
To help reduce risk of developing liver disease, consider making changes to your diet and get regular exercise.
Early Symptoms of Liver Disease
Common Causes of Liver Disease
Its widely accepted that most of the common causes of chronic liver disease are modifiable before they become an issue by altering your eating and health habits. The best treatment plans always start with prevention. Healthy living practices will be crucial after treatment to avoid relapse and chronic liver disease.The Liver is the largest organ in the human body and is fully capable of regenerating itself under normal conditions. Since the Liver has many responsibilities such as detoxification of the blood, fighting infections and aiding in the digestion of foods, it can be severely impact the overall health of a person if it becomes diseased.
Organ donors are very limited and the prices for liver transplants is very high and the surgery itself involves many risks. Thankfully, our Internationally trained stem cell regeneration doctors were able to create a more modern approach to healing. Adult stem cell therapies help induce the rapid production of hepatocytes in a patient with chronic liver disease and/or Cirrhosis of the Liver.
Liver Disease Treatment – Reverse Liver Scarring
Enhanced mesenchymal stem cells (MSC+) offer an attractive therapeutic solution to reverse hepatic cirrhosis and liver diseases based on many factors including:
- Immunomodulatory properties (24219905)
- Ability to differentiate into hepatocytes, biliary epithelial cells and liver progenitor cells
- Natural replacement of damaged hepatocyte cells
- Reduction of pro-inflammatory cytokines
- Reversing hepatocellular damage and repair hepatic ducts & hepatic plates
- Promote persistent hepatocyte regeneration (17901986)
- Capacity to inhibit cell activation
- Stop Fatigue. Jaundice. Constant Itching.
- Increases rate of apoptosis ( paracrine mechanism )
With recent advancements in regenerative medicine for failed kidney, heart attacks and diabetic nephropathy, there is finally an effective alternative liver regeneration treatment to repair fatty liver & chronic liver disease using targeted protocol of liver cells and growth factors.
TREATMENT RISKS & PRECAUTIONSTreatment for familial conditions using gene therapies are not available. Patients with severe thrombocytopenia, coagulopathy limiting travel will not qualify for the 2-3 week treatment protocol. please contact us for .
The liver is generally made up of cells called hepatocytes (22306885). The enhanced liver cells are capable of replicating so that new hepatocytes will be replacing old hepatocytes naturally after 200 to 300 days of use. If a patient’s liver is severely damage, the natural replicating process cannot be completed by the hepatocytes. This is where oval cells come to the rescue. It is believed that oval cells are also capable of producing new hepatocytes should the need arise. Combo treatment for Liver failure is done as outpatient procedure and looks to introduce therapeutic levels of hepatocytes liver cells and/or Hepatic oval cells use the paracrine mechanism to forcefully initiate in the healing of damaged tissues and cells.(23197664)
Combination MSC+ Hepatic Cell treatment protocol can also be done by using expanded Adult multipotent stem cells and hepatic growth factors. Multipotent stem cells are capable of differentiating into different kinds of cells including hepatocytes (liver cells).(1645698)
After Infusion of Liver Stem Cells – Oval Cell Therapy
Treat Cirrhosis of the Liver Stage 4 + Hepatocyte Cells
Computed Tomography Angiography or CTA is often used for delivery of stem cells to a very precise method of hepatocytes or oval cell delivery using a catheter. The femoral catheter used can be
guided to appropriate areas of damage (24187451). The damaged tissues/livers being treated requires about 60-90 minutes in total per treatment stage over a period of 2-3 weeks in total.
Severe cases may require several stages. Enriched MSC+ Hepatocyte cells vary per treatment stage. Liver regeneration therapy use a combination of enriched MSC+ Differentiated hepatocyte cells, biliary epithelial cells and liver progenitor cells. Enhanced cells are delivered through the combination of IV Drips (Intravenous),Direct infusion and/or Intrathecal delivery.
Chronic Liver Disease Treatment Conditions
Due to the varying degrees of existing liver damage and the current stage all potential patients must provide recent medical documents for review. The treatment for Liver cirrhosis, liver fibrosis or chronic liver Disease with stem cells can require 14-21 days in Bangkok. Upon approval for therapy, a detailed medical plan will be provided and will include specifics regarding the medical treatment, exact length of stay needed along with the total expenses for the treatment. To learn more about a Treatment for Fatty Liver, Liver Cirrhosis or chronic liver disease with stem cells please contact us today.