stemcell treatment liver disease arman

Stem Cell Treatment for Liver Disease & Cirrhosis

UPDATED August 22, 2020 – According to international statistics, chronic liver disease ranks #4 around the world as the top causes of mortality. Once a human liver incurs severe damage, it usually cannot repair itself naturally, thus may posing life-threatening risks to the patient. Given this, the only possible treatment options for chronic liver disease was with a dangerous complete liver transplant. Unfortunately, there are a lot of risks to consider with liver transplant surgery. [1] The risk is mainly attributed to the tendency of rejection of transplanted organs. Sometimes the body detects the transplanted organ as a “foreign object,” or something that has not come from its own body, therefore, should be destroyed/rejected.

liver cirrhosis

Types of Hepatic Diseases

The liver is a complex and vital organ, and there are over a hundred various classifications of liver disease. These most common types of liver disease include:

  • Alagille Syndrome is a genetic disorder coolly seen in young children and infants.
  • Alcohol-Related Liver Diseases, also known as “drug-induced” or “toxic” liver failure, this disorder is typically due to overconsumption of alcohol or drugs or due to an immune reaction to certain medications.
  • Alpha-1 Antitrypsin Deficiency is a genetic disorder that can lead to liver disease or emphysema lung failure. Patients with Alpha-1 Antitrypsin Deficiency are often misdiagnosed with Asthma
  • Autoimmune Hepatitis (AIH) is a chronic condition that occurs when patients own immune system attacks the liver causing it to be inflamed continuously and unable to heal itself naturally. If left untreated autoimmune hepatitis can lead to liver cirrhosis and Hepatic failure.
  • Benign Liver Tumors – Some tumors are cancerous (malignant), while others are benign (noncancerous). Noncancerous (benign) liver tumors do not spread in the body, and typically do not pose any severe health threat.
  • Biliary Atresia is typically a genetic disorder in newborn children affecting the production of bile and the bile ducts. Biliary atresia disease caused the bile ducts to become blocked and inflamed, causing the bile liquid to remain in the liver and leading to scarring (cirrhosis) the liver.
  • Budd-Chiari syndrome is a rare condition caused by blockage (occlusion) of the hepatic veins. Symptoms of Budd-Chiari syndrome include ascites, abdominal pain, and liver liverfailuregeneticenlargement.
  • Cirrhosis of the liver occurs with healthy liver tissue gets replaced with non-living scar tissue. This condition is usually a symptom of several other liver diseases.
  • Crigler-Najjar Syndrome (CNS) occurs when there is high-level bilirubin (toxin) in the blood (hyperbilirubinemia). Bilirubin is the byproduct of breaking down red blood cells but must be removed from the body through the bile and intestines. High levels of bilirubin in the blood can lead to jaundice and can also travel to the brain and cause brain damage.
  • Fascioliasis (Hepatic fascioliasis) is caused by parasitic infection of the liver by a liver fluke (Fasciola hepatica)
  • Fatty liver disease or hepatic steatosis occurs when triglyceride fat rapidly accumulates in liver cells.
  • Non-alcoholic fatty liver disease (NAFLD) is a family of conditions that are usually associated with metabolic syndromes like diabetes 2 or obesity.
  • Galactosemia is a genetic disorder that prevents patients from processing sugar galactose. Rapid accumulation of galactose in the body can result in dangerous complications such as renal failure, PKD, enlarged liver, brain damage, or cataracts in the eyes.
  • Gilbert Syndrome which is a genetic disorder that prevents the liver from processing bilirubin. This condition is more common in men than in women and can cause jaundice.
  • Hemochromatosis is a common genetic disorder which causes patients to absorb and store too much iron in the body. The abundance of iron buildup can be very dangerous for several organs, especially the liver and if left untreated can lead to organ failure.
  • Hepatic Encephalopathy, also known as portosystemic encephalopathy (PSE), is a medical condition that affects the brain function of patients with severe liver disease and the inability to remove toxins from the blood. If these toxins build up, they travel throughout the body until they reach the brain resulting in physical and mental dysfunction.
  • Hepatitis inflammation of the liver can be caused by several factors, including viruses (viral hepatitis), liver toxins, autoimmune response, or hereditary conditions.
  • Hepatitis A liver disease is caused by the hepatitis A virus (HAV) and causes the liver to get swollen and prevent it from functioning correctly.
  • Hepatitis B liver disease is usually preventable and caused by the hepatitis B virus (HBV). A Hepatitis B diagnosis can cause the liver to enlarge and prevents proper function. Hep B is treatable, and over 95% of adults who are exposed to Hep B recover in 1 year or less. Chronic Hepatitis B is severe and can result in cirrhosis of the liver, liver failure, or liver cancer.
  • Hepatitis C liver disease is caused by the Hepatitis C virus (HCV). Hep C can be autoimmune and causes severe inflammation in the liver, which leads to scarring and liver fibrosis. The cellular death of liver cells triggers the body to release inflammatory cells in the liver which then leads to hepatomegaly (enlargement of the liver) and also causes the Glisson’s capsule (fibroelastic sheath) around the organ to stretch causing pain.
  • Hepatorenal Syndrome (HRS) is a dangerous condition that reduces kidney function in patients with advanced liver disease. Hepatorenal Syndrome common in patients with advanced scarring in the liver and ascites but can also happen in patients with acute liver failure, fulminant hepatic failure, or other types of liver diseases.
  • Intrahepatic Cholestasis during Pregnancy (ICP) is a condition that affects the flow of bile acids in the liver resulting in the pregnant woman to continually itch. This complication usually appears in the third trimester, when hormone concentrations are highest.
  • Lysosomal Acid Lipase Deficiency (LAL-D) a progressive genetic disorder that restricts a patients ability to produce lysosomal acid lipase enzyme. The body needs this vital enzyme to breakdown lipids (fats) and cholesterol. When the lysosomal acid lipase enzyme is deficient or missing, fats begin to accumulate in tissue and organs throughout the body resulting in liver disease along with high levels of LDL bad cholesterol that is linked to cardiovascular diseases.
  • Liver cysts are benign but abnormal growths sacs in the liver that are filled with fluid
  • Liver Cancer occurs when malignant cells in the liver grow and spread. Any cancer that starts in the Liver is called liver cancer, and Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the most common type of liver cancer, and if the disease spreads from the liver to other organs, it’s diagnosed as metastatic liver cancer. When pancreas cancer spreads, it typically affects the liver. Different rare types of liver cancer include hemangiosarcoma and angiosarcoma of the liver.
  • Primary biliary cirrhosis or Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that causes damage to the intrahepatic bile ducts.
  • Primary Sclerosing Cholangitis (PSC) liver disease is a chronic disease that slowly damages the bile ducts and then travels to the small intestine. Patients with PSC suffer from constant inflammation and fibrosis (scarring) of tissue that causes bile accumulation in the liver until it loses all ability to function correctly. PSC advances slowly, and liver failure can occur 8-15 years after initial diagnosis. Most patients with people with Primary Sclerosing Cholangitis will need a liver transplant, but stem cell therapy for Primary Sclerosing Cholangitis can be useful if applied soon after diagnosis. PSC can also result in bile duct cancer.
  • Reye Syndrome can affect all organs in the body but especially harmful to the liver and brain. Reye Syndrome often occurs in children recovering from viral infections, like chicken pox and the flu. Complications of Reye syndrome in the Oliver can include abnormal liver function tests, fatty liver deposits, poor blood clotting, or total liver failure.
  • Wilson Disease is a genetic disorder that causes the patient to retain excess copper deposits in the body and not release copper into bile fluid as it usually should. Copper builds up in the blood and liver can lead to damage in the kidneys, eyes, and brain. If left untreated, Wilson’s disease can result in severe brain damage, kidney failure, liver failure, and death.

Diagnosis & Genetic Testing for Liver Diseases

Blood Tests and radiology scans used to diagnose liver failure include:
Liver Panels & Liver Function Test (LFT),Complete Blood Count Comprehensive Metabolic Panel (CMP),Alpha-1 Antitrypsin, Bilirubin, DCP, AFP Tumor Markers, Albumin, Total Protein, GGT, PT, AMA, AST, ALP, ALT, Copper Test (hepatic copper concentration), Ethanol tests, Overdose Drug Testing, Iron Tests, Hepatitis A Test, Hepatitis B and Hepatitis C Tests.

The regeneration center and its functional medicine department offer a comprehensive list of DNA testing options to test for inheritable liver & glycogen storage diseases, including the following panels:
ATP7B, SPG70, JAG1, NOTCH2, ILLD, METRS, MRS, FBP1, SLC5A1, SLC2A2, PHKA2 G6PC, GBE1,SLC37A4, PYGL GYS2, PHKB, PHKG2,FBP, FBPase 1 & RpL17

To help reduce the risk of developing liver disease, consider making changes to your diet, and get regular exercise.

Early Symptoms of Liver Disease

stages of liver failure

Common Causes of Liver Disease

Compare-End-Stage-Liver-Disease-Cure-Treatment

Its widely accepted that most of the common causes of chronic liver disease are modifiable before they become an issue by altering your eating and health habits. The best treatment plans always start with prevention.  Healthy living practices will be crucial after treatment to avoid relapse and chronic liver disease. The Liver is the largest organ in the human body and is fully capable of regenerating itself under normal conditions. Since the Liver has many responsibilities such as detoxification of the blood, fighting infections, and aiding in the digestion of foods, it can severely impact the overall health of a person if it becomes diseased.

Organ donors are very limited, and the prices for liver transplants is very high, and the surgery itself involves many risks. Thankfully, our Internationally trained stem cell regeneration doctors were able to create a more modern approach to healing. Adult stem cell therapies help induce the rapid production of hepatocytes in a patient with chronic liver disease or Cirrhosis of the Liver.

Liver Disease Treatments

Enhanced mesenchymal stem cells (MSC+) offer an attractive therapeutic solution to reverse hepatic cirrhosis and liver diseases based on many factors, including:liver-stemcells

  • Immunomodulatory properties [2]
  • Ability to differentiate into hepatocytes, biliary epithelial cells and liver progenitor cells
  • Natural replacement of damaged hepatocyte cells
  • Reduction of pro-inflammatory cytokines
  • Reversing hepatocellular damage and repair hepatic ducts & hepatic plates
  • Promote persistent hepatocyte regeneration [3]
  • Capacity to inhibit cell activation
  • Stop Fatigue. Jaundice. Constant Itching.
  • Increases rate of apoptosis (a paracrine mechanism )

Hepatocyte Cells to Reverse Liver Scarring

With recent advancements in regenerative medicine for failed kidney, heart attacks, and diabetic nephropathy, there is finally an effective alternative liver regeneration treatment to repair fatty liver & chronic liver disease using targeted protocol of liver cells and growth factors. Chronic parkinsonism is also associated with liver cirrhosis.[4]

TREATMENT RISKS & PRECAUTIONS
Treatment for familial conditions using gene therapies are not available. Patients with severe thrombocytopenia, coagulopathy limiting travel will not qualify for the 2-3 week treatment protocol. Please contact us for.

bangkok-cell-therapy-kidney-hepatocytes-cirrhosis-treatment-pricesThe liver is generally made up of cells called hepatocytes [5]. The enhanced liver cells are capable of replicating so that new hepatocytes will be replacing old hepatocytes naturally after 200 to 300 days of use. If a patient’s liver is severely damaged, the natural replicating process cannot be completed by the hepatocytes. This is where oval cells come to the rescue. It is believed that oval cells are also capable of producing new hepatocytes should the need arise. Combo treatment for Liver failure is done as an outpatient procedure and looks to introduce therapeutic levels of hepatocytes liver cells or Hepatic oval cells use the paracrine mechanism to initiate in the healing of damaged tissues and cells forcefully.[6]

Combination MSC+ Hepatic Cell treatment protocol can also be done by using expanded Adult multipotent stem cells and hepatic growth factors. Multipotent stem cells are capable of differentiating into different kinds of cells, including hepatocytes (liver cells).[7]

After Treatment of Liver with Stem Cells

Oval Cell Therapy for Liver Cirrhosis Stages

Computed Tomography Angiography or CTA is often used for delivery of stem cells to an exact method of hepatocytes or oval cell delivery using a catheter. The femoral catheter used can be

treatment-Cirrhosis-stem-cells-therapy

guided to appropriate areas of damage [8]. The damaged tissues/livers being treated requires about 60-90 minutes in total per treatment stage over 2-3 weeks in total.

Severe cases may require multiple stages to stabilize liver function. Amounts of enhanced MSC+ Hepatocyte cells vary per treatment stage. Liver regeneration therapy uses a combination of hepatocyte cells, biliary epithelial cells, and liver progenitor cells. Expanded exogenous liver cells are delivered through the combination of IV Drips (Intravenous), Direct infusion, or Intrathecal delivery.

Guidelines for Treating Chronic Liver Disease

Due to the varying degrees of existing liver damage and the current stage, all potential patients must provide recent medical documents and liver radiology scans for review. The treatment for Liver cirrhosis, hepatic fibrosis, or chronic liver Disease with stem cells can require 14-21 days in Bangkok.  Upon approval for therapy, a detailed medical plan will be provided and will include specifics regarding the medical treatment, exact length of stay needed along with the total expenses for the treatment. To learn more about a Treatment for Fatty Liver, Liver Cirrhosis, or chronic liver disease with stem cells, please contact us today.

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Published Clinical Citations

  • [1] ^ Angulo, Paul, David E Kleiner, Sanne Dam-Larsen, Leon A Adams, Einar S Bjornsson, Phunchai Charatcharoenwitthaya, Peter R Mills, et al. 2015. Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease in Thailand. Gastroenterology, no. 2 (April 29). doi:10.1053/j.gastro.2015.04.043. https://www.ncbi.nlm.nih.gov/pubmed/25935633

  • [2] ^ Burkhard, Pierre R, Jacqueline Delavelle, Renaud Du Pasquier, and Laurent Spahr. Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration. Archives of neurology, no. 4. https://www.ncbi.nlm.nih.gov/pubmed/12707065

  • [3] ^ Cantz, Tobias, Michael P Manns, and Michael Ott. Stem cells in liver regeneration and therapy. Cell and tissue research, no. 1 (September 28). https://www.ncbi.nlm.nih.gov/pubmed/17901986

  • [4] ^ Esrefoglu, Mukaddes. 2013. Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure. World journal of gastroenterology, no. 40 ( 28). doi:10.3748/wjg.v19.i40.6757. https://www.ncbi.nlm.nih.gov/pubmed/24187451

  • [5] ^ Shi, Ming, Zheng Zhang, Ruonan Xu, Hu Lin, Junliang Fu, Zhengsheng Zou, Aimin Zhang, et al. 2012. Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients. Stem cells translational medicine, no. 10 (October 11). doi:10.5966/sctm.2012-0034. https://www.ncbi.nlm.nih.gov/pubmed/23197664

  • [6] ^ Srivatanakul, P, D M Parkin, M Khlat, D Chenvidhya, P Chotiwan, S Insiripong, K A L’Abbé, and C P Wild. Liver cancer in Thailand. II. A case-control study of hepatocellular carcinoma. International journal of cancer, no. 3 ( 30). https://www.ncbi.nlm.nih.gov/pubmed/1645698

  • [7] ^ Zimmermann, Joshua A, and Todd C McDevitt. 2013. Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion. Cytotherapy, no. 3 (November 9). doi:10.1016/j.jcyt.2013.09.004. https://www.ncbi.nlm.nih.gov/pubmed/24219905

  • [8] ^ Allameh, Abdolamir, and Somaieh Kazemnejad. 2012. Safety evaluation of stem cells used for clinical cell therapy in chronic liver diseases; with emphasize on biochemical markers. Clinical biochemistry, no. 6 (January 27). doi:10.1016/j.clinbiochem.2012.01.017. https://www.ncbi.nlm.nih.gov/pubmed/22306885