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Therapy pathway

Hashimoto’s
Thyroiditis

Evidence-informed care begins with diagnosis review and individual eligibility.

Stem Cell Regeneration CenterBangkok, Thailand
Stem Cell Treatment for Hashimoto’s thyroiditis for Stem Cell Treatment for Hashimoto’s Disease & Chronic Thyroiditis.
Page last updated Medically reviewed

Hashimoto’s disease is an autoimmune condition that can cause an underactive thyroid, also known as hypothyroidism, or less commonly, an overactive thyroid, known as hyperthyroidism.

Hashimoto’s disease & Chronic thyroiditis

This disease affects the thyroid gland, a small gland in the neck that produces thyroid hormones that control the body’s energy usage and influence various organs, including the heart. Hashimoto’s disease produces antibodies that attack the thyroid gland, accumulating white blood cells in the gland and ultimately leading to its damage, impairing its ability to produce enough thyroid hormones [1].

Hashimoto’s thyroiditis disease is one of the most common thyroid disorders in the world and the most common cause of hypothyroidism, affecting as many as 0.3-1.6 cases per 1000 persons in the world. The disease is named after the Japanese surgeon who discovered it in 1912.

Hashimoto’s disease is also called:

  • Hashimoto’s thyroiditis
  • Autoimmune Thyroiditis
  • Chronic lymphocytic thyroiditis

Current research shows that Hashimoto’s disease is four to ten times more common in women than men and is likely to develop more often in women aged 30-55. It can also be hereditary, and individuals who have a family history of thyroid diseases or other autoimmune disorders such as Thymoma-associated myasthenia gravis, Type 1 diabetes, Ankylosing Spondylitis, Lupus, Connective Tissue Disease, Rheumatoid Arthritis, autoimmune pancreatitis, and Sjogren’s Syndrome are at a higher risk of developing it. Learn more about genetic testing for Autoimmune diseases.

What does Hashimoto’s disease do to a person?

Hashimoto’s disease may cause several health complications, including high cholesterol levels, high blood pressure, heart disease, heart attack, stroke, and heart failure. Additionally, hypothyroidism can cause myxedema, a rare and life-threatening condition that slows down the body’s functions. Untreated hypothyroidism can also lead to pregnancy-related problems [2].

What are the symptoms of Hashimoto’s disease?

The symptoms of Hashimoto’s disease may not be apparent initially. However, as the condition progresses, the symptoms and complications from hypothyroidism may include:

Anatomy guide

Thyroid gland and follicles

The thyroid in the neck and a closer view of its follicles.

Thyroid gland and follicles. Numbered key: Thyroid lobes; Isthmus; Trachea; Thyroid follicle.

1. Thyroid lobes
The two lobes beside the upper trachea.
2. Isthmus
The bridge of thyroid tissue joining the lobes.
3. Trachea
The airway passing behind the thyroid isthmus.
4. Thyroid follicle
A rounded structure lined by follicular cells.
The thyroid may become enlarged, leading to a swollen neck appearance called a goiter. Rarely, thyroid damage may cause too much thyroid hormone to be released into the bloodstream, resulting in hyperthyroidism.

What tests are used to confirm Hashimoto’s disease?

Diagnosis of Hashimoto’s disease is based on a medical history and physical examination, and Antithyroid antibody tests that may include tests for thyroid hormones, thyroid-stimulating hormone, Free T4, and thyroid peroxidase antibodies (TPO), which are found in most people with Hashimoto’s disease. A thyroid ultrasound or CT scan may sometimes be necessary to confirm the diagnosis. While the exact cause of Hashimoto’s disease is unknown, genetic factors and viral infections, such as hepatitis C, are thought to play a role. Some medicines and exposure to environmental toxins may also cause hypothyroidism.

Illustration of autoimmune thyroiditis affecting the thyroid gland for Stem Cell Treatment for Hashimoto’s Disease & Chronic Thyroiditis.

Treatments for Hashimoto’s Thyroiditis

When Hashimoto’s disease causes hypothyroidism, NIDDK describes levothyroxine replacement and laboratory monitoring. Treatment and dose should be individualized by the treating clinician. T3 or desiccated thyroid should not be presented as the default treatment, and extra iodine can be harmful for some people with autoimmune thyroid disease. The attached limbal-cell/T-cell experiment is not a thyroid-treatment guideline. [3]

Regular exercise can also help manage symptoms, boost energy levels, and improve mood. Working closely with your doctor to manage Hashimoto’s disease is essential, as untreated hypothyroidism can lead to serious health complications. However, most people with non-complicated Hashimoto’s disease can live healthy, fulfilling lives with proper treatment and management.

Stem Cell Treatment for Hashimoto’s Disease

Hashimoto’s thyroiditis is an autoimmune disease where lymphocytes destroy the thyroid gland. The current and traditional methods of treating the disease include surgery, hormone therapy, or immunomodulatory therapy, but they pose significant risks and side effects. This calls for finding new ways to treat the disease, including modified stem cells for Hashimoto’s disease. The Regeneration Center Stem Cell Clinic uses isolated UC-MSC+ stem cells and immune-modulating growth factors to help regulate Th17/Treg interactions in patients with Hashimoto’s thyroiditis. Our stem cell research and recent clinical trials have shown that UC-MSC+ stem cells can be a beneficial and safe immunotherapy strategy for treating the disease [4].

Medical illustration of antibodies surrounding an inflamed thyroid gland for Stem Cell Treatment for Hashimoto’s Disease & Chronic Thyroiditis.

Isolated and Expanded UC-MSC+ cells have unique properties, such as being easily harvested from various stroma (autologous and allogeneic), carrying Major Histocompatibility Complex (MHC) antigens that are not frequently expressed, and being able to target injured organs or tissues. These properties make them promising for treating immune diseases, especially autoimmune disorders like Hashimoto’s.

New treatment for Hashimoto’s thyroiditis

Autoimmune thyroid diseases (AITDs) target the functioning follicular cells, and many cytokines and immune cells are involved. Hashimoto’s thyroiditis is recognized as an AITD, characterized by lymph cell infiltration, fibrotic changes, and parenchymal atrophy. UC-MSC+ isolated from a combination of umbilical cord tissue and Wharton’s jelly has therapeutic functions for patients with Hashimoto’s disease. The isolated UC-MSC+ cells and growth factors used in our treatment help reduce thyroid lesions through lymphoid infiltration by regulating Th17/Treg cell interactions. The isolated UC-MSC+ cells are also given specific growth factors to help force the migration of newly transplanted cells to the inflammatory sites in the body.
Clinical guide

Cell sources and terminology

A guide to the source labels used in the laboratory illustration.

  1. Adipose tissue

    ADSC

  2. Bone marrow

    BM-MSC

  3. Peripheral blood

    PB-MSC

  4. Placental tissue

    P-MSC

  5. Umbilical cord

    UC-MSC

  6. UC-MSC+

    The Regeneration Center’s terminology used in this article.

What type of stem cells are used for Hashimoto's thyroiditis?

The protocol described for Hashimoto's thyroiditis uses UC-MSC+ cells isolated from umbilical cord tissue and Wharton's jelly, given together with growth factors. Wharton's jelly is a gelatinous substance inside the umbilical cord and a rich source of mesenchymal stem cells. These cells are being researched for immunomodulation, and the protocol aims to help regulate Th17 and Treg immune cell interactions.

Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs)ArticleWharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs)Read the article

Stem Cell Therapy for Thyroid Issues

The thyroid gland is a vital component of our endocrine system, responsible for secreting hormones that regulate cellular metabolism and development. Insufficient thyroid hormone levels can impair central nervous system function and cause low intelligence quotient and mental retardation. Hypothyroidism, a condition where the production of thyroxine is reduced, is often caused by autoimmune thyroid diseases such as fibrotic thyroiditis. Additionally, thyroid malignancies, including papillary thyroid cancer, follicular thyroid cancer, and anaplastic thyroid cancer, are a significant concern. Patients with advanced-stage carcinoma, particularly those with anaplastic thyroid cancer, often lose the chance for surgery once the diagnosis is confirmed, underscoring the urgent need for alternative functional medical treatments.

Role of stem cells in thyroid cell differentiation, thyroiditis & thyroid cancers

The cited paper concerns thyroid-hormone signaling in intestinal stem cells and their niche. It is not a study showing that cord-tissue MSCs replace thyroid tissue or treat Hashimoto’s disease. Cell origin, laboratory differentiation and clinical endocrine function are distinct questions and should not be combined into a claim of thyroid regeneration. [5]

Stem cell treatment for rheumatoid arthritis represents a promising new treatment option that will revolutionize the management of this chronic and debilitating disease. Although the biological treatment is still in the early stages of stem cell science, the results are encouraging, and we will only continue to get better results over time.

Cost of Treating Hashimoto’s with Stem Cells

UC-MSC+ Stem Cell treatment for Hashimoto’s & Chronic Thyroiditis will require an estimated 10-14 days in total. Due to the varying degrees of severity, our medical team will need to evaluate the current health of all potential patients to recommend an appropriate protocol. Upon completion of the medical review, a detailed treatment plan will be provided, including the types and quantities of cells, the total number of nights required, and the total medical-related costs for the entire program. To begin the evaluation process for our multi-stage rheumatoid arthritis treatment using stem cells, please prepare your recent medical records such as radiology scans w/ blood test results and contact us today.

Published Clinical Citations

[1] ^ Tempark T, Deekajorndech T, Chatproedprai S, Supornsilchai V, Wananukul S. Late sequelae of drug reaction with eosinophilia and systemic symptoms (DRESS) cause thyroid dysfunction and thyroiditis: review of literature. Journal of pediatric endocrinology & metabolism : JPEM. 2022;35(5):567. doi: 10.1515/jpem-2021-0685. PubMed: 35119800.

[2] ^ Rajatanavin R. Postpartum thyroid dysfunction: a viewpoint from Thailand. Ann Acad Med Singap. 1993 Jul;22(4):587-92. PMID: 8257065.

[3] ^Coppola A, Tomasello L, Pitrone M, Cillino S, Richiusa P, Pizzolanti G, Giordano C. Human limbal fibroblast-like stem cells induce immune-tolerance in autoreactive T lymphocytes from female patients with Hashimoto’s thyroiditis. Stem Cell Res Ther. 2017 Jul 3;8(1):154. doi: 10.1186/s13287-017-0611-5. PMID: 28673339; PMCID: PMC5496215.

[4] ^Al-Suhaimi EA, Al-Khater K. Functions of stem cells of thyroid glands in health and disease. Rev Endocr Metab Disord. 2019 Jun;20(2):187-195. doi: 10.1007/s11154-019-09496-x. PMID: 31025266.

[5] ^ Giolito MV, Plateroti M. Thyroid hormone signaling in the intestinal stem cells and their niche. Cell Mol Life Sci. 2022 Aug 10;79(9):476. doi: 10.1007/s00018-022-04503-y. PMID: 35947210.

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