UPDATED February 13, 2019 Alzheimer’s is also known in medical literature as Alzheimer’s Disease (AD) is the most common type of dementia. As of Today, there are no effective pharmaceutical based therapies for the illness.
The condition is terminal and if left untreated will eventually lead to death. AD is usually being diagnosed in old people, aged sixty five years plus, but of course, it can also occur in an earlier age.In 2018, there were an estimated 45 million people suffering from AD throughout the world. Alzheimer’s is predicted to affect one in every eighty individuals globally by the year 2040.(24964731). As recently as last year, diagnosis of dementia has quickly skyrocketed to become the fifth largest cause of death worldwide. Alzheimer’s makes up about 70% of these cases. Alzheimer’s disease is currently diagnosed based on several factors including amyloid plaques and tau tangles “neurofibrillary tangles” (NFTs) which are toxic proteins in the brain and result in cognitive decline and eventually dementia. These self-propagating prion proteins are amyloid beta (A-β) and tau. Patients with higher levels of these prions are associated with early-onset alzheimers.
What are Prions / Double-Prion Disorders?
Prions are defective proteins that spread similar to infections in the human body. These proteins force good copies of proteins into the defective misfolded shapes that destroy the brain. The double-prion disorder refers to the two rogue proteins Tau and amyloid beta. Recent research has shown clear underlying causes of neurodegenerative diseases caused by consistent buildup of toxic misfolded proteins that are sometimes referred to as “prion-like” and can now be measured much quicker than in the past.
Signs & Symptoms of Alzheimer’s & Dementia
Dementia and Alzheimers show a wide variety of symptoms including personality changes, memory loss followed by severely impaired intellectual/cognitive functions that arise from the disease itself or from any trauma to the brain. Such symptoms are NOT part of the normal aging cycle and are usually severe enough to impact the daily activities, relationships and independence of the affected persons. Alzheimer’s “AD” is the most common known type of dementia, but there are other diagnosed forms of the neurodegenerative disease including vascular dementia and mixed dementia.
What is the difference between dementia and alzheimer’s?
Patients with dementia, usually have a rapid decline in memory function, learning, communication and solving simple problems. For some, these changes take several years to occur but for many, the neurological function deteriorates very quickly and if left untreated, will not be reversible.
The rate of progression and eventual outcome of TDP-43 proteinopathy, AD and dementia vary patient to patient, but is usually determined by the area of the brain that is effected and the type of dementia which they are diagnosed with.(18549326) Early diagnosis and treatment are the patient’s best hope. Thanks to modern tests for the disease, early detection is quite simple using advanced brain imaging such as CT Scans, MRI’s, clinical examinations from neurologists and other diagnostic tests.
Common symptoms & signs of Double-prion Disorders such as AD and dementia:
- Loss of communication skills
- Rapid Memory loss
- Motor Function,Gait and balance issues
- Difficulty making decisions
- Difficulty with abstract thoughts
- Faulty reasoning
- Senile behaviour
- Inappropriate verbal and physical behavior
- Impaired judgment
- Sundowners Syndrome
- Autonomic neuropathy
- Disorientation of time and location
- Paranoia, frequent agitation or Hallucinations
- Complete neglect of personal hygiene and safety
People with Dementia and Alzheimer’s might also:
- Asks the same question repeatedly
- Cannot recognize family or friends
- Unable to remember or follow directions
- Become lost or disoriented in very familiar places
What is Sundown Syndrome?
Sundowning or “late-day confusion” is a common neurological symptom of dementia and Alzheimer’s disease. Patients and family members taking care patients with dementia need to be aware that confusion and frequent agitation might depend of time of day. The most dangerous type of Sundowning behavior include frequent Hallucinations or wandering away from home. Sundowners often experience pronounced symptoms in the late afternoon or evening. Sundowning often occurs in middle-stage to advanced dementia.
4 Types of Dementia
Dementia symptoms are often very similar which is why there is often trouble determining which type of dementia a patient might have. To make matters more complicated, some patients experience multiple types overlapping symptoms and therefore get diagnosed with “mixed dementia.” There are also cases of familial Dementia however the odds are very low ( less than 5% of all cases) and genetic testing can be done to confirm or deny hereditary involvement. The four most common forms of dementia are:
- Alzheimer’s Disease generally occurs after a rapid buildup of tau tangles or amyloid plaque proteins in the brain.
- Lewy Body Dementia occurs when abnormal proteins appear in nerve cells and result in impaired cell signaling or function.
- Frontotemporal Dementia occurs when the temporal or frontal lobes of the human brain shrink or get damaged.
- Vascular Dementia usually occurs after damage caused by brain strokes.
Stem Cell Treatment for Alzheimers
Alzheimer’s disease affects each individual in a distinct way, there are still the usual indicators that one is suffering from the disease. Early warning signs are more usually misconceived to be normal aging process or just manifestations of stress and depression. In the early stage, the most common signs you can observe are difficulty in remembering current happenings. Potential Parkinson’s Disease and AD patients, can be diagnosed and verified through examinations that gauge behavior and thinking abilities, followed with an more thorough examination of the brain or a CT brain scan. As the diseases becomes more apparent, the warning signs can include being frustrated easily, irritated easily, becoming much more hostile, wild mood swings, difficulty in speech, language and the long-term loss of memory. As the patient becomes more and more affected, they usually begin to isolate themselves from their family and the community. The body is affected gradually, and unfortunately, this leads to death.
Like ALS Disease, Alzheimers affects each person distinctively and the displayed symptoms can be similar to patients with multiple sclerosis and Ataxia. Consequently, this makes it harder to predict how it will play out. AD could worsen without the patient’s knowledge and be left undiscovered for a long time. The usual lifespan for people diagnosed with Alzheimer’s is roughly three to seven years. Less than three percent of patients can live up to fourteen years or longer after being diagnosed with AD.(25206630) This is exactly where adult stem cell treatment for Alzheimer’s comes into the picture.
Stem Cell Treatment for Dementia
There are a few medications that are approved for treatment of cognitive symptoms due to Alzheimer’s including cholinesterase inhibitors (Exelon,Aricept,Razadyne) and memantine HCL (Namenda). Side effects of these medications include vomiting, loss of appetite, nausea, constipation, confusion,dizziness, headaches and chronic bowel movements. For those with early onset alzheimer’s or who have not responded well to traditional dementia medications, The Regeneration Center offers a unique and effective treatment plan to repair brain damage caused by lewy body dementia. Our functional therapies use neurotrophic growth factors along with exogenous and/or endogenous cells to induce synaptogenesis which then helps to replenish damaged/lost neuronal connection/signal systems and helps reduce amyloid plaque in hippocampus region of the brain. The cultured cells offer immunomodulation capacity with anti-apoptotic activity, and introduce neurogenic properties to the damaged regions from the human brain where they proliferate and matured to neurotransmitters and functional neurons. Sensory precursor cells can be intravenously dealt with but it can also be directly implanted into the brain-damaged locations and bring about recovery of the patient. There is also substantial proof that transplanted stem cells or the neural precursor cells (NPCs) can survive, stir and gradually develop into neurons, oligodendrocytes and astrocytes via a process known as neurogenesis. Stem cells, in addition to replacement of lost and/or damaged cells, can also induce endogenous neural precursors, help boost the structural neuroplasticity, and regulate pro-inflammatory cytokines and the neuronal apoptotic death.(25022790)
How Neural Cell Replacement Therapy Works
In order to push growth elements into the brain, stem cells can also be genetically modified. Studies indicate that the full-grown brain of the mammals preserves the capability to produce new neurons from the neural stem or progenitor cells. Stem cell therapy for memory loss is one of the most practical and effective way to repair the damages brought about by Brain Injuries, Strokes, Alzheimer’s and of course, to recover intellectual function and quality of life for the patient and family affected by the disease.(24783773)
Alternative Treatment for Alzheimer’s (Neural Stem Cell Replacement Therapy)
Approved treatment protocol for Alzheimer’s disease using Neural stem cells will require a minimum of 14-21 nights in Bangkok. Due to varying degrees of cognitive and physical degeneration, our medical team will need to review any patient medical files before acceptance. Once our review is complete we can offer detailed treatment plan that includes the complete treatment steps including an exact number of nights required along with the total and fixed medical related costs.
Rehabilitation Post-Therapy – Physical Rehab sessions after treatment is optional but highly recommended regardless of where it takes place (Thailand or your home country). Depending on the patients timing constraints, physical rehab in Thailand can be provided upon request for 2-4 hours per day and up to 6 days per week. In addition, medical visas and extended stay accommodations at hotel or furnished apartments for the patient and family can also be provided upon request.
To begin the qualification process for our multistage treatment protocol please prepare your recent medical records such as Brain MRI’s, PET scan or CT Scan and contact us today.