heart-disease-treatment-stemcells-cad

Stem Cell Therapy for Coronary Artery Disease CAD IHD

UPDATED August 07, 2019Cardiovascular diseases are one of the major causes of fatality in the world. Over the years, the rate of deaths caused by cardiovascular diseases has decreased in some countries while dramatically increasing in others. The percentage of premature deaths from cardiovascular illness ranges from a low of 3% in nations with a high GDP of up to 49% in low-GDP nations. More than 250 million individuals across the worlds lost their lives due to coronary heart disease and cardiovascular diseases in 2011. According to cardiac stem cell research, each year heart illness kills significantly more humans than cancer. In recent years, Cardiometabolic and cardiovascular dangers in women have been growing at a fast rate and have killed a higher percentage of women than breast cancer has.

Stem Cell Treatment for Ischemic Heart Disease

Therapeutic cardiomyocyte regeneration using hematopoietic mesenchymal stem cells. Replace dead cardiomyocytes with functionally integrated cardiac and vascular endothelial cells (cardiogenesis.) Decrease inflammation and Angiogenesis to increase blood vessel growth for the heart.

Causes of Coronary Artery Disease

Coronary Heart Disease “CHD” is also known as coronary artery disease “CAD.” CAD or CHD are conditions in which the coronary arteries are weakened due to plaque buildup in our blood circulatory system. The arteries are primarily responsible for providing blood and oxygen to the heart. Stem Cell Therapy for Heart Disease can be a good choice for those seeking a safe, non-surgical alternative treatment for most cardiac diseases, including Chronic Ischemic Arteries and Coronary Heart Disease.

CAD-coronary-artery-atherosclerosis

Acute Coronary Syndromes – Coronary Thrombosis

  1. Unstable acute angina (chest pain) symptom occurs when the heart doesn’t get enough oxygen or blood flow. Symptoms vary, but for most patients, the symptoms start occurring more frequently over time during periods of rest. Over time the angina pain starts to last longer and feels more severe. Traditional treatments such nitroglycerin may be used but if left untreated the issue to result in a heart attack.
  2. NSTEMI or Non-ST segment elevation myocardial infarction is a type of heart attack that may not register on an electrocardiogram (ECG). There are, however, markers in blood tests that can be used to screen for events or damage to the heart muscle. For most NSTEMI patients, the artery blockage may be temporary or partial.
  3. STEMI or ST-segment elevation myocardial infarction is the other type of heart attack caused by a blockage in the blood supply. STEMI events affect large areas of cardiac tissue and can be measured by an ECG test or blood panels screening for the specific enzymatic activity and chemical markers. These biochemical markers in blood tests are known as cardiac risk markers of inflammation. The tests were developed from the earliest diagnostic markers of troponins (troponin complex) & Creatine kinase-MB (CK-MB)

Signs of Atherosclerosis & Coronary Plaque

Symptoms for patients with ischemic heart disease vary for all patients, but new blood tests and genetic testing for hereditary heart disease can be used as an early warning sign of acute coronary syndrome.clogged-artery-coronary atherosclerosis

Plaque is produced because of the cholesterol, calcium, fat, and other substances found in the blood. When the plaque starts to build up in your arteries, you get diagnosed with a disease called atherosclerosis. The building up of the plaque takes place over many years. As time passes by, the plaque narrows your coronary arteries and thus hardens. This is the cause of the limited oxygen-rich blood in the heart.

The plague-infested region can also rupture, or break open. This forms a blood clot on the surface of the plaque. When this worsens, and the blood clot becomes more prominent, this disturbs the blood flow in the coronary artery. Moreover, angina or a heart attack might happen if your heart does not receive a regular flow of blood and fresh oxygen. Angina is a severe discomfort in the chest. It might feel like there is a pressure or squeezing inside your chest. The pain also might happen inside your neck, shoulders, arms, back or, jaw. Angina discomfort might even really feel like indigestion.

A heart attack happens when the regular flow of blood rich in oxygen to the section of the heart is disrupted or blocked. If this flow is not remedied immediately, the particular part of the heart will not function. Without immediate treatment, a heart attack can occur, and this may lead to death. With time, CHD will make the heart weaker, and this could result in peripheral neuropathy, arrhythmia, muscular atrophy, and often heart failure.

Heart disease is a condition where the heart cannot pump sufficient blood required by the body. Arrhythmia has something to do with the abnormal rhythm and rate of the heartbeat.(23467912)

Signs of Coronary Heart Disease

CAD, CHD, and IHD Cardiomyopathy can happen due to many reasons, including environmental conditions, lifestyle, and genes. Some common risk factors for heart disease include:

Is Coronary Artery Disease Hereditary?

It is estimated that over 40% of all CAD cases might have some hereditary influence and the most commonly diagnosed genetic heart diseases include:(30110045)

heriditary heart disease

  • Genetic Arrhythmia
  • Hypercholesterolemia
  • Pulmonary arterial hypertension
  • Connective tissue disorders
  • Aortopathy
  • Hypertrophic Cardiomyopathy
  • Hemorrhagic telangiectasia
  • Congenital heart disease
  • Brugada Syndrome
  • Catecholaminergic polymorphic ventricular tachycardia
  • Short QT Syndrome
  • Long QT Syndrome

Diagnosis of Heart Disease

The clinical diagnosis of heart disease requires diagnostic tests and physical exams. A cardiologist uses several tests to determine the severity including Echocardiogram, Electrocardiogram (ECG), angiograms, CT coronary angiogram, heart Stress tests (nuclear stress test), Cardiac catheterization, and blood tests. The regeneration center offers a comprehensive list of genetic panels to screen for mutations in genes that lead to hereditary heart diseases using the following panels:
TNNC1, TNNI3, JUP,DOLK,TAZ,CAV3, CRYAB, CSRP3, DES,VCL,RBM20, RYR2, SCN5A, SGCD,TCAP, TMEM43, LAMP2, LMNA, MYBPC3,PKP2, PLN, PRKAG2, RAF1,EYA4,ABCC9,DSC2, DSG2, DSP, EMD, MYH7, MYL2, MYL3, ACTC1, ACTN2,GAA, GLA, HCN4, AGL, BAG3,TNNT2, TPM1,FHL1, FKRP, FKTN, FLNC, TTN, TTR, SLC22A5, CACNA1C, ANKRD1, DMD, CTNNA3,LDB3 and PDLIM3.

DNA screening tests are recommended for family members of patients who had sudden cardiac death. Early intervention is often key in managing the disease, so if the direct relatives of the deceased think they might carry an inherited disorder/gene mutation, then screening would be advised. We do not offer gene therapies to treat heart disease, but there are several clinical trials underway to cure genetic heart diseases. To help reduce any risk of developing Coronary Artery Disease and ischemic heart diseases consider making dietary changes and getting regular exercise.

TREATMENT PRECAUTIONS & RISKS
Please note Cardiac stem cell transplants are not appropriate for all cardiovascular diseases. Heart Cell Therapy, cardiac tissue, and cell engineering are limited options for those with severe heart muscle damage. Patients with severe scarring, late stage, or those with travel restrictions will not qualify for the 14-21 day treatment time needed. Please contact us for more information

New Treatment Options for Heart Disease

There are several methods to treat coronary artery disease depending on the stage, severity, and underlying cause of the condition. The first line of defense for patients with heart disease requires immediate lifestyle changes, medications, surgical procedures, or cardiac stem cell therapy to manage the disease. Angioplasty-vs-CABG
Some common medications and non-surgical treatments for CHD, CAD & IHD include:

  • Antiplatelet medications (Clopidogrel)
  • Beta-blockers
  • Nitroglycerin
  • Cholesterol-lowering medications (statins)
  • Calcium channel blockers
  • Percutaneous Coronary Revascularization
  • Heart Stem cell therapy

Patients who do not respond well to medications or have reached a severe stage of heart disease might require surgery to restore and improve blood flow. Common surgical procedures for heart disease include:

  • Open-heart surgery
  • Angioplasty
  • Coronary bypass surgery
  • CABG: coronary artery bypass graft
  • A balloon to widen a coronary artery
  • Coronary artery stent

Treat Heart Disease with Stem Cells

Stem cell therapy is a new alternative,non-surgical treatment option and can help reverse heart disease. (23238707) The impact of enhanced stem cell therapies are better understood now more than ever, and The Heart Regeneration Center offers a unique and effective cardiac regeneration protocol depending on patients needs. Cardiac cell transplants and targeted paracrine signaling help rebuild a patient’s heart tissue by utilizing clinical grade hematopoietic mesenchymal stem cells. For most elderly patients or those with severe physical limitations, a combination of allogeneic cell therapy will be required.  This option is only available for patients whose own cells are not sufficient or impotent due to age or other diseases. The stem cells are immune-system compatible and expanded from cardiosphere-derived stem cells to help assist replenish/replace damaged heart cells and reverse coronary heart disease symptoms. (24326234) The enriched stem cells are then placed them back into the heart generally via a process known as homing using multiple stage delivery over two weeks.

1 Year After Stem Cell Treatment for CHD

The benefits of having regenerative therapy to treat Acute coronary syndrome include:cardiac-cells

    • Reduction in the infarct size / Reduction in heart muscle scar (24560743)
    • Improved regulation of O2 (Oxygen) Intake and Use  (24282814)
    • Greater Reduction in Angina  (18381874)
    • Noticeable improvement in the patients overall well-being and condition in Life.
    • Long-term benefits (≥12 months) with measurable improvement in well-being & physical endurance.
    • Reduction in heart muscle scar size, infarct size with reduction of cardiogenic shock
    • Improvement of Left ventricular ejection fraction resulting in no need of rehospitalization

Treat Cardiovascular Diseases with Cardiopoietic Cellsheart-stem-cells


Total Number of Stem Cell Infusions: 2-8 Infusion of Endogenous Mesenchymal Cardiomyocyte cells & Exosome growth Factors (per Treatment stage requirement) Multiple Stages may be required for severe conditions

Cardiac Rehabilitation Post Treatment: Cardiac Rehabilitation therapy in Bangkok is optional and can be provided for a minimum of 2 hours per day and five days per week. 
Medical visas and accommodations for the patient and family/friends at an extended stay service apartment or hotel can also be included upon request.

Total Time Required for Cardiac Treatment is: Estimated around two weeks in total (depending on the patients’ medical needs)

Guidelines for Heart Stem Cell Treatment

Our cardiac regeneration treatment protocol is a comprehensive combination treatment and needs to be performed in multiple stages. For most patients, this will require the ability to travel to Thailand for the 2-3 week adjuvant therapy. Due to the varying degrees/severity of the patient and other underlying medical factors, the medical team will need to evaluate all potential patients before a prognosis can be provided. Upon acceptance, a detailed treatment plan will be provided to the patient that will include the specifics of the recommended medical protocol, the total length of stay required, along with a fixed price for all related medical costs. To begin the qualification process for the Regeneration Center Heart Disease treatment, please prepare all recent medical records such as an Echocardiogram, EKG, Tilt Table Heart CT Scan or SPECT exam (Single-photon emission computed tomography) and contact us today.

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Published Clinical Citations

TREATMENT RELATED QUESTIONS

15 comments

  • Hello, guest
  • Hello, My name is sasha and i live in Ukraine. am 56 years old and diagnose with coronary occlusive disease and atherosclerosis 2 yer ago. My doctor want me have open heart surgery aorto-coronary bypass but because of my health and weight it very risky so I looking for option with stemcell and no surgery. Can steamcell help recover me?  
    • Support Team
      Hello Mr Sasha, Thank you for contacting us about treatment for Coronary artery disease & Atherosclerosis. We have emailed you more information and program overview as you requested.
  • Hello from Sweden!  I'm 45 and was diagnosed with Coronary artery disease 3 years ago. Recently I have been having a lot of numbness and tingling in my hands and feet. My Blood pressure is also very unstable and goes up and down alot. Not having any cramping but heavy feeling leg and feeling very tired overall. I just had a CT scan and some other tests done that I would like to send to you for review to see if the stem cells treatment will help me.
  • I have a 72 year old female friend, who has the rare condition of pulmonary edema that has damaged her heart. She was just diagnosed, and was told by her doctors that she is expected to live to the end of this year (2017) She has fluid in the lung…which needs to be drained periodically. Do you have any cutting edge treatments for this condition at your Center ? Even to extend life in the patient with this condition, and reverse some heart damage ? Thank you, Cathy Reinheimer, U.S.A.
  • Hello, I currently have 11 stents and one of my coronary arteries is fully occluded. How much experience does your clinic have in treating CAD? What would the % of successful treatments be?
  • My father is having an LVEF of 32% to 35%. With severe MR. All the chambers are dilated. He had a CABG in 1999. He again had an interior wall MI in January this year. Can your treatment help him?
  • I'm 53 year old male and was diagnosed with Coronary Heart Disease in March of 2015. I only found out after i was hospitalized that my E.F. had dropped down to 19%. It went up slightly to 25% in September, but now it's back down to 20%. My question is am i candidate? if so, about how much is cost? do you accept insurance?
  • My 56yr old husband is having some serious heart issues. He had a triple bypass and artificial valves put in around June of last year. His recovery seemed to be ok after a few weeks, but since then he says he does not feel any better than he did before his surgery. His chest pains are becoming more frequent and his blood pressure is getting worse. Doctors are also telling he he may be pre diabetic. He was a long time smoker but quit 2 years ago after 35 years of smoking nearly 1/2pk day every day. I dont expect him to get back to where he was before surgery but hoping we can improve the his stamina and quality life. What tests do you need from us to get a medical review?
  • I don't understand....I have blocked arteries, my heart thankfully is fine so far. I have had 3 stents and then finally a cabg. What does this do to clear or create new arteries ??? Thanks
    • Support Team
      Hello Mr Jim The goal of our cord blood stem cell therapy for heart disease is to reduce ischemia (artery blockage) with increase in blood flow through creation of new blood vessels (angiogenesis). For the coronary artery bypass graft (CABG) portion the goal would be to improve factors like left ventricular (LV) function that can help improve tolerance to physical exercise. Please note this is a general scenario and each patients' need is different. For more information about how our treatment can help your specific needs, please email us at heart@stemcellthailand.org.
  • My question is - are there any stem cell trials currently going on for chronic heart failure (cardiomyopathy) that I could possible get into. I am currently on the heart transplant list. Thanks, Randy
    • Support Team
      Hi Randy, Thanks for contacting us. What country do you live in? Please email us so we can assist you in finding a clinical trial for cardiomyopathy using stem cells.
  • I had a pretty severe heart attack last year and am having a very difficult time feeling normal. I know that my heart is damaged but I’m hoping stem cell transplants can help restore some of my strength back. Right now i have constant shortness of breath, mild chest pain and im currently taking Antiplatelets, warfarin and some ACE inhibitors plus 7 other medications. Im 47 years old, don’t smoke and am pretty healthy otherwise. Am i a good candidate for your cardiac cell therapy?
  • Can i use mesenchymal stem cells to repair my weak heart function? I was diagnosed with myocardial ischemia last year and condition is getting worse. My Ejection fraction has gone from 35% to 10%. What can stem cells do?