Stem Cell Therapy for Heart Disease Atherosclerosis CAD IHD
Cardiovascular diseases are one of the major causes of fatality in the world. Over the years, the rate of deaths caused by cardiovascular diseases has decreased in some countries while dramatically increasing in others. The percentage of premature deaths from cardiovascular illness ranges from a low of 3% in nations with a high GDP of up to 49% in low-GDP nations. More than 250 million individuals across the worlds lost their lives due to coronary heart disease and cardiovascular diseases in 2021. According to cardiac stem cell research, each year heart illness kills significantly more humans than cancer. In recent years, Cardiometabolic and cardiovascular dangers in women have been growing at a fast rate and have killed a higher percentage of women than breast cancer has.
Therapeutic cardiomyocyte regeneration using hematopoietic mesenchymal stem cells. Replace dead cardiomyocytes with functionally integrated cardiac and vascular endothelial cells (cardiogenesis.) Decrease inflammation and Angiogenesis to increase blood vessel wall growth in the heart.
Causes of Coronary Artery Disease
Coronary Heart Disease “CHD” is also known as coronary artery disease “CAD.” CAD or CHD are conditions in which the coronary arteries are weakened due to plaque buildup in our blood circulatory system. The arteries are primarily responsible for providing blood and oxygen to the heart. Stem Cell Therapy for heart artery blockage can be a good choice for those seeking a safe, non-surgical alternative treatment for most cardiac diseases, including Chronic Ischemic Arteries and Coronary Heart Disease.
Acute Coronary Syndromes – Coronary Thrombosis
Unstable acute angina (chest pain) symptom occurs when the heart doesn’t get enough oxygen or blood flow. Symptoms vary, but for most patients, the symptoms start occurring more frequently over time during periods of rest. Over time the angina pain starts to last longer and feels more severe. Traditional treatments such nitroglycerin may be used but if left untreated the issue to result in a heart attack.
NSTEMI or Non-ST segment elevation myocardial infarction is a type of heart attack that may not register on an electrocardiogram (ECG). There are, however, markers in blood tests that can be used to screen for events or damage to the heart muscle. For most NSTEMI patients, the artery blockage may be temporary or partial.
STEMI or ST-segment elevation myocardial infarction is the other type of heart attack caused by a blockage in the blood supply. STEMI events affect large areas of cardiac tissue and can be measured by an ECG test or blood panels screening for the specific enzymatic activity and chemical markers. These biochemical markers in blood tests are known as cardiac risk markers of inflammation. The tests were developed from the earliest diagnostic markers of troponins (troponin complex) & Creatine kinase-MB (CK-MB)
Signs of Atherosclerosis & Coronary Plaque
Symptoms for patients with ischemic heart disease vary for all patients, but new blood tests and genetic testing for hereditary heart disease can be used as an early warning sign of acute coronary syndrome.
Plaque is produced because of the cholesterol, calcium, fat, and other substances found in the blood. When the plaque starts to build up in your arteries, you get diagnosed with a disease called atherosclerosis. The building up of the plaque takes place over many years. As time passes by, the plaque narrows your coronary arteries and thus hardens. This is the cause of the limited oxygen-rich blood in the heart.
The plague-infested region can also rupture, or break open. This forms a blood clot on the surface of the plaque. When this worsens, and the blood clot becomes more prominent, this disturbs the blood flow in the coronary artery (coronary atherosclerosis.) Moreover, angina or a heart attack might happen if your heart does not receive a regular flow of blood and fresh oxygen. Angina is a severe discomfort in the chest. It might feel like there is a pressure or squeezing inside your chest. The pain also might happen inside your neck, shoulders, arms, back or, jaw. Angina discomfort might even really feel like indigestion.
A heart attack happens when the regular flow of blood rich in oxygen to the section of the heart is disrupted or blocked. If this flow is not remedied immediately, the particular part of the heart will not function. Without immediate treatment, a heart attack can occur, and this may lead to death. With time, CHD will make the heart weaker, and this could result in peripheral neuropathy, arrhythmia, muscular atrophy, and often heart failure.
Heart disease is a condition where the heart cannot pump sufficient blood required by the body. Arrhythmia has something to do with the abnormal rhythm and rate of the heartbeat.[1]
Signs of Coronary Heart Disease
CAD, CHD, and IHD Cardiomyopathy can happen due to many reasons, including environmental conditions, lifestyle, and genes. Some common risk factors for heart disease include:
The clinical diagnosis of heart disease requires diagnostic tests and physical exams. A cardiologist uses several tests to determine the severity including Echocardiogram, Electrocardiogram (ECG), angiograms, CT coronary angiogram, heart Stress tests (nuclear stress test), Cardiac catheterization, and blood tests. The regeneration center offers a comprehensive list of genetic panels to screen for mutations in genes that lead to hereditary heart diseases using the following panels:
TNNC1, TNNI3, JUP,DOLK,TAZ,CAV3, CRYAB, CSRP3, DES,VCL,RBM20, RYR2, SCN5A, SGCD,TCAP, TMEM43, LAMP2, LMNA, MYBPC3,PKP2, PLN, PRKAG2, RAF1,EYA4,ABCC9,DSC2, DSG2, DSP, EMD, MYH7, MYL2, MYL3, ACTC1, ACTN2,GAA, GLA, HCN4, AGL, BAG3,TNNT2, TPM1,FHL1, FKRP, FKTN, FLNC, TTN, TTR, SLC22A5, CACNA1C, ANKRD1, DMD, CTNNA3,LDB3 and PDLIM3.
DNA screening tests are recommended for family members of patients who had sudden cardiac death or with low heart function. Early intervention is often key in managing the disease, so if the direct relatives of the deceased think they might carry an inherited disorder/gene mutation, then screening would be advised. We do not offer gene therapies to treat heart disease, but there are several clinical trials underway to cure genetic heart failure. To help reduce any risk of developing Coronary Artery Disease and ischemic heart diseases consider making dietary changes and getting regular exercise.
TREATMENT PRECAUTIONS & RISKS
Please note Cardiac stem cell transplants for are not appropriate for all cardiovascular diseases and may require coronary artery bypass grafting surgery. Heart stemcell therapy, cardiac tissue manipulation, and cell engineering are limited options for those with severe heart muscle damage. Patients with severe scarring, late stage, or those with travel restrictions will not qualify for the 14-21 day treatment time needed. Please contact us for more information
New Treatment Options for Cardiovascular Diseases
There are several methods to treat coronary artery disease depending on the stage, severity, and underlying cause of the condition. The first line of defense for patients with coronary atherosclerosis requires immediate lifestyle changes, medications, surgical procedures, or cardiac stem cell therapy to manage the disease.
Some common medications and non-surgical treatments for coronary artery disease (CAD),CAD & IHD include:
Antiplatelet medications (Clopidogrel)
Beta-blockers
Nitroglycerin
Cholesterol-lowering medications (statins)
Calcium channel blockers
Percutaneous Coronary Revascularization
Heart Stem cell therapy
Patients who do not respond well to medications or have reached a severe stage of cardiac disease might require surgery to restore and improve blood flow. Common surgical procedures include:
Total Number of Cardiac Stem Cell Infusions: 2-8 Infusion of Endogenous Mesenchymal Cardiomyocyte cells & Exosome growth Factors (per Treatment stage requirement) Multiple Stages may be required for severe conditions
Play Video about comparison-mesenchymal-stemcell-sources-viability-potency-regen
Cardiac Rehabilitation Post Treatment: Cardiac Rehabilitation therapy in Bangkok is optional and can be provided for a minimum of 2 hours per day and five days per week. Medical visas and accommodations for the patient and family/friends at an extended stay service apartment or hotel can also be included upon request.
Total Time Required for CAD heart treatment is: Estimated around two weeks in total (depending on the patients’ medical needs)
Our heart regeneration treatment protocols for coronary artery atherosclerosis and heart disease offer a comprehensive treatment and needs to be performed in multiple stages. For most patients, this will require the ability to travel to Thailand for the 2-3 week adjuvant therapy. Due to the varying degrees/severity of the patient and other underlying medical factors, the medical team will need to evaluate all potential patients before a prognosis can be provided. Upon acceptance, a detailed treatment plan will be provided to the patient that will include the specifics of the recommended medical protocol, the total length of stay required, along with a fixed price for all related medical costs. To begin the qualification process for the Regeneration Center Heart Disease treatment, please prepare all recent medical records such as an Echocardiogram, EKG, Tilt Table Heart CT Scan or SPECT exam (Single-photon emission computed tomography) and contact us today.
[5] ^ Pratumvinit, Busadee, Kanit Reesukumal, Kajohnkiart Janebodin, Nicholas Ieronimakis, and Morayma Reyes. 2013. Isolation, characterization, and transplantation of cardiac endothelial cells. BioMed research international (October 27). doi:10.1155/2013/359412. https://www.ncbi.nlm.nih.gov/pubmed/24282814
[6] ^ Varga, E, C Nemes, R P Davis, O Ujhelly, N Klincumhom, Z Polgar, S Muenthaisong, M K Pirity, and A Dinnyes. 2014. Generation of transgene-free mouse induced pluripotent stem cells using an excisable lentiviral system. Experimental cell research, no. 2 (February 18). doi:10.1016/j.yexcr.2014.02.006. https://www.ncbi.nlm.nih.gov/pubmed/24560743
[7] ^ Windmolders, Severina, Astrid De Boeck, Remco Koninckx, Annick Daniëls, Olivier De Wever, Marc Bracke, Marc Hendrikx, Karen Hensen, and Jean-Luc Rummens. 2013. Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells. Journal of molecular and cellular cardiology (December 8). doi:10.1016/j.yjmcc.2013.11.016. https://www.ncbi.nlm.nih.gov/pubmed/24326234
Page last updated: 28 February 2023 | Topic last reviewed: 11 September 2022