Stem cell therapy is an emerging treatment option for people with osteoporosis and skeletal disorders. Enhanced Mesenchymal stem cells are special cells that can be used to treat various medical conditions, including osteoporosis and skeletal disorders. Stem cells can be derived from adult or embryonic sources and can be used to repair, regenerate and replace damaged or missing tissue. The traditional therapeutic methods used in the past for osteoporosis can usually only prevent the loss of bone mass but only recover the bone partially.
Bone & Cartilage Diseases
Diseases of skeletal system are quite common for the elderly population and are generally considered to be one of the primary causes of physical disability and morbidity. The most common diseases of the skeletal system include:
- Bone fractures
- Osteoarthritis (OA)
- Rheumatoid arthritis (RA)
- Intervertebral disc Disease (IVDs)
- Lumbar Spinal Stenosis
- Degenerative Disc Disease (DDD)
- Osteogenesis imperfecta (OI) 
The use of stem cell therapy in the treatment of osteoporosis and skeletal disorders is still in its early stages. However, research has shown that stem cell therapy may be able to help contain the disease, reduce pain, improve mobility and even increase the strength of bones affected by osteoporosis. In addition, it has been found that stem cell therapy can help to reduce the risk of fractures in patients with osteoporosis.
Stem Cell Treatment for Osteoporosis
The Regeneration Center offers a unique protocol using isolated and expanded stem cells for treating osteoporosis. This safe new therapeutic strategy, can increase osteoblast differentiation and reversing the previous shift towards bone resorption in patients with mild to moderate osteoporosis. Cell therapy and regenerative medicine have the potential to bring back the structure and function of normal tissues.
Stem cell-based therapy focuses on chronic illnesses like osteoporosis. As we age we people can begin to have reduced bone mass or skeletal tissue atrophy, which increases the risk of osteoporotic fractures, characterizes osteoporosis, one of the significant causes of morbidity in older men and post-menopausal women. The most frequent and traditional treatment options for osteoporosis only stop further bone thinning and partially restore bone mass.
Bone Regeneration Therapy
Stem cell-based therapies offer a novel strategy for regenerating bone tissue. By isolating specific populations of mesenchymal stem cells we are able to harness its natural anti-inflammatory, immune-privileged potential and without ethical concerns than other types of stem cells such as embryonic cells. These cells are vital components in regenerative medicine, especially bone regeneration. According to several published studies, the secretory function of mesenchymal stem cells has a significant role in their effectiveness.
Indeed, they can start particular molecular signalling pathways, which can contribute to the formation of normal bone remodeling.
Osteoporosis is a long-term, chronic skeletal condition that is more prevalent among the elderly. Therefore, reduced bone mass and mineral density is often to blame for most elderly having fractures. Additionally, osteoporosis is said to be brought on by an imbalance in the bone cells’ and characterized by low bone mass and microstructural degradation of bone tissue, which increases bone fragility and fracture risk. Compared to other portions of the bone, the proximal ends of the humerus and femur, the distal end of the radius, and the vertebral column are more prone to osteoporotic fractures. In addition, hip fractures are a significant catalyst of death and high morbidity rates. In recent years, stem cell therapies have attracted significant attention to the field of tissue engineering and regenerative medicine to treat various disorders and degenerative orthopedic issues such as DDD lower back pain, knee injuries, shoulder injuries, spinal injures and osteoarthritis.
Stem Cells’ Role in Osteoporosis & Bone Remodeling
Osteoporosis is a complex illness that has both endogenous and external components. By reducing fracture susceptibility, enhancing lost mineral density, and modulating bone resorption, MSCs+ stem cells can be incredibly helpful in containing and reversing symptoms of osteoporosis.
The treatment works by raising the quantity of progenitor stem cells and enhancing their capacity for cell division and differentiation into bone-forming cells. Stem cells, especially MSC+ stem cells, can support bone regeneration by secreting bioactive molecules such as IGF-1, TGF-, vascular endothelial growth factor (VEGF), angiogenin, hepatocyte growth factor (HGF), and IL-6. This is because the bone tissue repair cascade can be controlled by local signals from different cytokines and growth factors by inducing osteoprogenitor cell migration, cell differentiation, proliferation, revascularization, and extracellular spaces. Exosomes produced by MSCs, are additional elements whose effects on halting bone loss and fostering bone remodelling processes (during osteogenesis, osteoclastogenesis, and angiogenesis) have been proven in clinical settings.
Stop Osteoporosis with Mesenchymal Stem Cells
For patients with osteoporosis endogenous MSC function is diminished as we age reducing its ability to proliferate, differentiate, and induce bone formation.
MSC+ from umbilical cord tissue and hematopoietic stem cells offer us many advantages in clinical use, including accessibility and ease of harvesting, immunosuppressive effects, the capacity for multi-lineal differentiation (especially the ability to differentiate into osteoblasts), and the absence of any possibility of malignant transformation. The adult stem cells can also be obtained from numerous tissue origins because they are a subset of stromal stem cells. One sources of MSC+ cells utilized to treat osteoporosis are those derived from bone marrow (BM-MSCs), which have a high capacity for osteogenic development. Our research has provided evidence suggesting that altering the molecular processes that control osteoblast development in MSCs will improve the efficacy and dependability of osteoporosis stem cell treatments.
Paracrine Effects on Bone Regeneration
While clinical trials have shown that MSC+ cells paracrine activities and ability to sustain a regenerative state have more therapeutic effects than their ability to differentiate. To put it another way, MSC transplantation has ushered in a new era of targeted therapies for osteoporosis, specifically through paracrine effects of mesenchymal cells. By secreting bioactive growth factors like Insulin-like growth factor 1 (IGF-1), Transforming growth factor (TGF-), Vascular Endothelial Growth Factor (VEGF), Hepatocyte Growth Factor (HGF), Interleukin-6 (IL-6), and Fibroblast Growth Factor, Mesenchymal Stem Cells (MSCs) can aid in bone repair (FGF) much more effectively.
The Regeneration Center Osteoporosis Protocol
Total Number of Stem Cell Infusions: Total number of Endogenous Mesenchymal Stem cells and exosomes growth factors will vary based on patient needs. Depending on the injury requirements needed, the treatment infusions can be done via a Guided Radiograph (when necessary) through an Intravenous Drip, Direct injection or Intrathecally.
Rehabilitation Post Treatment: Physical Rehabilitation in Bangkok is optional but highly recommended. Complete physical rehab services post-therapy can be provided upon request for 2-3 hours per day and up to 5 days per week.
Total Treatment Time Required: estimated around 2-3 weeks (depending on type and seriousness of condition). Medical and travel visas for extended stay accommodations at a hotel or extended stay apartment for the patient and family can also be provided upon request.
Osteoporosis Treatment Guidelines & Requirements 2023
MSC+ Stem Cell treatment for osteoporosis will require roughly 2 weeks in total. Due to the varying degrees of severity, our orthopedic team will need to evaluate potential patients so that an appropriate protocol can be established. Upon approval, a detailed treatment plan will be provided that will include the specifics such as exact total number nights required along with the total medical related costs.
Stem cell therapy for osteoporosis and skeletal disorders are not appropriate for all cases and conditions but has shown promising results. To learn more about the safe and effective MSC+ Stem Cell treatment for Osteoporosis please contact us today
Published Clinical Citations
 ^ Hu L, Yin C, Zhao F, Ali A, Ma J, Qian A. Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment. Int J Mol Sci. 2018 Jan 25;19(2):360. doi: 10.3390/ijms19020360. PMID: 29370110; PMCID: PMC5855582.
 ^ Li Y, Jin D, Xie W, Wen L, Chen W, Xu J, Ding J, Ren D, Xiao Z. Mesenchymal Stem Cells-Derived Exosomes: A Possible Therapeutic Strategy for Osteoporosis. Curr Stem Cell Res Ther. 2018;13(5):362-368. doi: 10.2174/1574888X13666180403163456. PMID: 29623851.
 ^ Aghebati-Maleki L, Dolati S, Zandi R, Fotouhi A, Ahmadi M, Aghebati A, Nouri M, Kazem Shakouri S, Yousefi M. Prospect of mesenchymal stem cells in therapy of osteoporosis: A review. J Cell Physiol. 2019 Jun;234(6):8570-8578. doi: 10.1002/jcp.27833. Epub 2018 Nov 29. PMID: 30488448.
 ^ Rudiansyah M, El-Sehrawy AA, Ahmad I, Terefe EM, Abdelbasset WK, Bokov DO, Salazar A, Rizaev JA, Muthanna FMS, Shalaby MN. Osteoporosis treatment by mesenchymal stromal/stem cells and their exosomes: Emphasis on signaling pathways and mechanisms. Life Sci. 2022 Oct 1;306:120717. doi: 10.1016/j.lfs.2022.120717. Epub 2022 Jul 2. PMID: 35792178.
 ^ Aswamenakul K, Klabklai P, Pannengpetch S, Tawonsawatruk T, Isarankura-Na-Ayudhya C, Roytrakul S, Nantasenamat C, Supokawej A. Proteomic study of in vitro osteogenic differentiation of mesenchymal stem cells in high glucose condition in Thailand. Mol Biol Rep. 2020 Oct;47(10):7505-7516. doi: 10.1007/s11033-020-05811-x. Epub 2020 Sep 11. PMID: 32918125.