Human embryonic stem cell line or hESC are also referred to as simply Embryonic stem cells. ES cells pertains to a pluripotent lineage of cells that are typically derived from a human embryo (after zygote) at its earliest stage.
Embyronic Stem Cell Biology
Embryonic cells of the morular are totipotent. ES cells are considered very powerful in regenerative medicine since they can undergo cell division even without differentiation, which could go for extended periods,(24092748) and eventually develop into the cells composing the three germ layers.
There are 3 types of pluripotent cells that occur:
- Embryonic Stem (ES) Cells. ES Cells can be isolated in the lab from the ICM or inner cell mass of a blastocyst.Embryos for ES cell treatments are usually produced naturally during IVF therapy. In most countries around the world including Thailand, harvesting ES cell lines from human donated blastocysts forbidden because the belief that it destroys a human embryo
- Embryonic Carcinoma (EC) Cells are is the 3rd type of pluripotent cell that can be isolated from teratocarcinomas (occasional tumors in the gonads of a fetus)
- Embryonic Germ (EG) Stemcells can isolated from the precursor to human gonads but requires aborted fetuses.
All 3 of the previous ES cells typically require isolation from fetal or embryonic tissue. Some ES lines such as induced pluripotent cells however can now be can be cultured in our labs using special growth medium but are still very difficult to control during mesoderm production and the differentiation process.(23658023)