rbihypoxia

Stem Cell Treatment for Traumatic Brain Injuries – TBI Repair

UPDATED May 17, 2019 – A Brain stem injury can occur via blunt force trauma to the brain no matter the age at onset. A head injury can result from a substantial handicap to the individual who sustained the brain injury and may trigger numerous types of cognitive impairments like lack of focus, memory or other motor-neurological disorders such as ataxiaALS, Spinal muscular atrophy or Parkinson’s Disease. A brain stem injury may also consist of any damage that’s vascular by nature and not by blunt force trauma event that directly caused or instigated the intracranial injury.

Etiology of Traumatic Brain Injury

Modern treatment options for head injuries are usually divided into two types, closed head injuries, and penetrating head injuries. Overlap for the two types does exist, and closed head injurytraumatic brain Injuries treatments can be further segmented into mild, moderate, or severe/traumatic head injuries.  A neurological injury is dissimilar from a traumatic brain injury (TBI) or stroke because an exterior force injures the brain in a damaging violent manner. TBI is an injury in the brain which is brought about by some the traumatic influence. TBI and brain stem damage can be caused by blows to the head (severe head trauma,) cerebral trauma, cranial penetration, or even violent trembling. Depending on the cause and severity of the trauma, the brain stem damage can be classified as serious, moderate or mild and damage from neurodegeneration can include, glial cells, neurons, endothelial cells, and Axonal Degeneration. (19017556)

Classifications of Traumatic Brain Injuries (TBI)

A TBI occurs after damage to the brain from external forces such as Impacts, rapid deceleration or acceleration, blast GlasgowComaScalewaves, or blunt force trauma. After such an incident, overall neurological impairment can be temporary or permanent depending on the severity of blunt force trauma to the head. The focus of this article will be to understand the signs, symptoms, and new treatment options for brain damage caused by traumatic head injuries that occur after birth only. There are currently two subsets brain damage, including traumatic and non-traumatic (non-penetrating) brain injuries resulting from exposure to toxins, brain stroke, or viral infections. Most brain injuries are classified as either neurotrauma or central nervous system injuries that can affect cell signaling and neurotransmitters, which can lead to other neurodegenerative conditions like dementia.

TBI is classified based on several factors including severity, causative forces, anatomical locations of the injury, and the mechanism. Mechanism-related injuries are either considered penetrating head injury or nonpenetrating/blunt/closed injury. An open or penetrating head injury happens when an object goes through the skull and breaches the outermost membrane of the brain known as dura mater.

Glasgow Coma Scale – GCS

Traumatic Brain injuries are classified into three categories, including mild, moderate, and severe. The most commonly used system around the world to classify TBI severity is known as The Glasgow Coma Scale (GCS). The GCS scale (3–15) grades a victim based on their level of consciousness, which is based on measuring motor, verbal, and eye-opening reactions. A brain injury with a GCS of 13 or above is considered mild, a head injury with a GCS score of 9–12 is deemed to be moderate, and any GCS score below eight is regarded as a severe head injury.

The GCS scale can also be changed after the victim is resuscitated, post-traumatic amnesia (PTA), or after recovering from the loss of consciousness (LOC). Other methods of classifying the severity of TBI include using neuroimaging scans from CT, MRI, or PET to measure brain swelling, diffuse injury, or focal lesions. A mild TBI is also commonly known as a concussion, but such an injury result in brain contusion or lead to trauma-induced paralysis.

Stem Cells used for Anoxic Brain Damage

Each region of the human brain and spinal cord possess various types of specialized cells. The Regen Center NeuroCell protocol works through usage of adult stem cells, for specific regions that help in the development of the cen­tral nervous system (CNS).

The goal of our Neural cell replacement therapy and spinal cord injuries is to target the damaged areas and then to repair or dead, damaged or diseased progenitor cells that are found in the neurogenic region.

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Initial symptoms and signs of the TBI could consist of:

  • Headaches
  • Blurred vision
  • Dizziness
  • Confusion
  • Seizures
  • Memory loss
  • Loss of consciousness
  • Paralysis
  • Coma

Focal vs. Diffuse Brain Injuries

Using a CT scan, TBI lesions can also be classified by their pathological features, including extra-axial or intra-axial. Extra-axial lesions refer to injuries that occur outside of the brain but inside the skull while intra-axial lesions refer to injuries that happen inside the brain tissue. Results from these injuries can be diffuse or focal or both depending on the severity of the damage.

Traumatic Brain Injury Symptoms

Symptoms of Diffuse injuries include edema (brain swelling) and damage to white matter tracts, cerebral hemispheres, and axons (diffuse axonal). Focal injuries, on the other hand, occur mostly in the orbitofrontal cortex and temporal lobes resulting in behavioral changes, problems with decision-making, language difficulties, and decision-making skills.

Focal lesions such as Hematomas result in the rapid collections of blood around the brain and can result in an Intracerebral hemorrhage stroke,subdural hematoma (bleeding between arachnoid mater & dura), subarachnoid hemorrhage (bleeding between arachnoid membrane and the pia mater), epidural hematoma (bleeding into dura matter) or intraventricular hemorrhage (bleeding in ventricles).

Treatment for TBI after Blunt Force Trauma

For optimal results, early intervention is the key to recovering from brain injuries that affected the nervous system. Response during the first 60 minutes after injury i.e., “golden hour” is recommended.(22336130) For most patients, treatment options depend on the age of injury and stage of recovery. Patients in the acute phase are looking to stabilize the condition from progressing using a combination of surgery and physical rehabilitation.

For Acute stages of TBI or injuries that occurred paying sports, maintaining proper blood flow to the brain is critical to avoid brain herniation and seizures. In this stage, Decompressive craniectomy (DC) can be used to relieve intracranial pressure along with hyperbaric oxygen therapies to ensure proper oxygen supplies are maintained. Neuroimaging from brain scans are also used to better target therapies using analgesics, Sedatives, paralytic agents and sometimes hypertonic saline to reduce swelling, regulate body temperature, hypotension, reduce risk of heart failure or avoid electrolyte imbalances.

Patients with TBI are at a much higher risk of complications and adverse side effects requiring contacting monitoring for signs of deterioration or loss of consciousness. Other complications of Traumatic Brain Injuries include pulmonary edema and cardiac arrhythmia. In chronic stages of TBI, Pharmacological based treatments can be used to treat behavioral (psychiatric issues) and post-traumatic epilepsy.

Reverse Damage From Brain Injury

Brain Stem cells transplantation into the affected region might be beneficial in certain circumstances wherein the damage is not too severe and has occurred relatively recently. (from 6 months up to two years after initial Injury) The neural stem cell implantation purpose would be to attempt to restore signal functions with comparable properties. In situations of TBI, numerous cell kinds are required (glial, neuronal, vascular, endothelial ) to regenerate the complex functions of largely damaged regions of the brain.(22162635)

cell-comparison-neural

Neural Cell Replacement Therapy

In much more severe instances of traumatic brain-related injuries such as Chronic traumatic encephalopathy (CTE), some complications can be fatal. While the rigorousness of the TBI

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differs broadly, the consequences of it, in the long run, are frequently devastating and life-changing. TBI is typically very sudden, and early intervention is the key to a full recovery. The physical, non-congenital harm towards the brain by an external force may permanently or temporarily disrupt regular brain function. (25072157) Brain characteristics and functions that may be affected include temporary or permanent loss of consciousness, speech, language, memory, character, mobility, joint pain with lupus, peripheral neuropathy and recognition of other people. Since the brain controls all bodily functions, any harm towards the brain, no matter how little or severe it is, can impair physical and psychological activity.

TREATMENT PRECAUTION
The Regeneration Center cannot accept patients with severe brain stem injuries or blunt force trauma accidents that are over 24 months old. All neurodegenerative disease treatments will also require physical ability to travel to Bangkok for the 2-3 week protocol.

Treatment Guidelines For Brain Injuries


Number of Sessions: Multiple Infusions of MSC+ cells from Bone Marrow (Autologous) or Allogeneic cells combined with exosomes, neural progenitor cells, fibroblast growth factors, cytokines or chemokines to allow for higher survival rates of transplanted cells per treatment stage. The types of cellular infusions vary based on patient needs, but for most acute brain stem injuries the goal of treatment is to help reduce systemic neuroinflammation, promote faster recovery of any lost cognitive function through the process of neurogenesis.(28293177)  Our cell delivery systems are very safe and administered via Stereotactic-guided delivery, inhalation therapy via micro-nebulized mesenchymal cells, Intravenous Drip, or Intrathecally.

Rehabilitation Post-Treatment: Physical Rehabilitation therapy in Bangkok is optional, depending on the patients’ travel/time constraints. Complete physical rehabilitation post-therapy and can be provided upon request for 2-4 hours per day and up to 5 days per week. 
Medical visas and extended stay accommodations for the patient and family can also be included upon request.

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Costs Related to Treating Brain Injuries with Stem Cells & Physical Rehab

Our treatments protocol for Traumatic Brain Injuries will require a minimum of 14-21 nights in Bangkok. Due to the significant differences in brain injury treatment requests, our medical team will need to qualify the potential candidate for treatment. Upon acceptance, a detailed treatment plan will be provided and include the specifics of the treatment plan that will include: total number nights required along with the total medical related expenses including cell extraction, enrichment, and infusions (excluding accommodations or flights). To begin the qualification process for the multi-stage TBI neural stem cell transplants,  please prepare your recent medical records such as recent Brain MRI’s, CT Scan (Preferred) or PET Scans and contact us today.

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Published Clinical Citations

TREATMENT RELATED QUESTIONS

24 comments

  • Hello, guest
  • My father suffered from a hypoxia injury. He has recovered substantially but still has problems with his mood and memory would he be a good candidate?
    • Support Team
      Hello Mr Martin, Thank you for contacting us. We have emailed you information that you requested about treatment for for fathers brain injury due to hypoxia.
    • Support Team
      Hello Mrs Pam, thank you for contacting the Regen Center. Based on the information provided your son would not be a good candidate for treatment. We have also emailed you with the information summary.
  • My 33 year old son had a really bad seizure in April 2016 and it damaged the right side of his brain. His right side still works, however the left side is paralyzed but he does have some movement on that side as well. The cognitive area has also been affected. He talks occasionally and does eat on his own somewhat. He is currently in a nursing home and we would like him to have a better quality of life.  
    • Support Team
      Hello Mr Skip, Thank you for contacting us about your treatment for traumatic brain injury ( right hemisphere ) An email was sent with the information requested.
  • Hi there, My beautiful little sister was recently involved in a traumatic car accident. She is a neuroscience major at the university of Miami in her second year. She is exceptionally bright and has so much to live for. She has been in a coma for a month now. Her injuries consist of multiple brain bleeds and hemorrhages that have since stoped, a level 3 diffuse axonal injury, along with a Duret hemorrhage. Is there any chance she may be a candidate for stem cell treatment? Could this make her the same amazing young woman she always has been? Please let me know if she can receive treatment, along with her chances of recovery with the treatment. She is currently at Massachusetts General Hospital in Boston and the doctors said she doesn’t have any chance of being herself again. Please tell me there is hope with this new research. Thank you for you time.
  • My Dad suffered an Acute Basilar Dissection and now has Locked In Syndrome. Can this therapy be used on brain stem injuries?
  • Hello,My brother, 37 years old now, fell down the stairs 7 years ago causing a brain haemorrhage on the right side of his brain resulting in traumatic injury and brain damage. He cannot talk or remember anything or anyone and has 24 hour care in a specialist hospital. It’s as if a reset button has been pressed on his head and erased his mind. Would he be a candidate for stem cell therapy. We would love for someone to take interest in his case and perhaps help with treating him. RegardsDavid
  • الخلايا الجدعية واريد ان اعرف بكم تكلف نا من الجزائر لدي ابني عمره 3سنوات  وعندما ولد اخبروني انه لديه ضمورفي المخ نتيجة نقص الاكسجين اثناء الولادة واخبروني انه لربما يشفيه
  • My son born with Hypoxia.  Brain damaged . 14 years old . Can't go can't talk . Any possibility help with stem cell?  S.Beyer. Germany 
  • Good MorningMy father suffered a cardiac arrest, at the end of January of this year. He was unresponsive for 20 plus minutes which starved his brain of oxygen as a result he has severe Anoxic brain damage (Acquired brain injury).He is in a minimally conscious state, he can track people, listen, and show emotion. He can't respond to commands yet, or verbalize what is the success rate of patient like my father who receive stem cell treatment? also what is the recovery range of such patients?thanksAndreas Georgiou
  • I had a severe haemorrhagic stroke 5 years ago in the lower rear right hemisphere of the Cerebrum. I spent 30 days in patent and 120 days later I returned to work. The residual effect after two years of hard work was a very positive one. Not much sleepiness from it, but vertical dizziness became much better (looking up or down). I experienced no confusion and spoke publicly as an instructor.My employer transferred me to another office that required that I move. In that move, a concrete mixer rear ended me at a high speed in my car which was filled with the heavy office equipment in the rear of it. Those objects were thrown forward and hit the two holes with no skull bone used for an exploratory Craniotomy about 35 mm. ea. in size.The Craniotomy surgery left the nerves on the back of the head useless as they were cut. As a result, I did not feel the impact from the objects. Basically, it was a closed brain injury. I experienced no "blackout" and continued on my journey, however, I ended up in a city I had no intention to go to - and did not remember driving there. I called a good friend on my Cell and told him what happened. He proceeded to instruct me to go to the hospital asap. 3 hours had passed after the accident had occurred.MRI's in the hospital showed no damage to the brain, but my memory, sleepiness, and confusion became much worst over a short period of time.My neurologist theorized that the heavy objects that hit the surgical incision for the Craniotomy pushed my brain forward, hitting my front skull bone, damaging my frontal lobe and its function.Today, 2.5 years after the accident, I persist in cognition rehabilitation. Issues of the loss of muscles, much poorer short-term memory, generalized severe communication issues, vertical dizziness, and depression have taken over my life now.Can any stem cell treatment overcome some if not most of these issues?
  • My daughter age 37 yrs suffered Hypoxic brain injury 12 days back, following a cardiac arrest due to massive Plurmology Embolism. She is out of ventilator but still in unconscious state with Motor 2 response. Any possible treatment?
  • My son is 14 months and drown but has some function for breathing only can i possibly get the other functions back
  • My father suffered brain stroke after his fourth cardiac arrest on 22nd feb 2017 . His brain was depreived of oxygen for almost 20 minutes. He was on ventilator and other life support system for 3 days. Right now he is in vegetative coma and has not resume full consciousness. He moves his eyes and sometimes also moves his other body parts. He has history of heart problem. He suffered his 1st minor heart attack in September 2005 and again suffered a major cardiac arrest after 4-5 days due to wrong treatment. He was then shifted to other hospital where he had undergone angioplasty surgery. He recovered well after this. 10 years later(december 2015) he again had a cardiac arrest and his stent was replaced by a new stent. Will stem cell therapy help him to recover?
  • I have hemiplegia from an open head injury. I really need a clinical trial or stem cells.
  • My main problem is sleeping disability and mitochondria. Problem started after high dose fluoroquinolone (13.000mg total doze in two weeks course of nucleus fluoride base) medication on August 2015. Can stem cells help?
  • My problems are pain in spinal cord, neck and often in head (when I use brain too much). Problems with memory, concentration, and vision. Vision is blurred. Dots in vision. Problems came about in Connection with high-dose medication of valaciclovir in March-June 2015. In April-May I took 6 gram per day, in March 4 grams per day. In short, I suffer the consequences of neurotoxicity. EEG was normal, and MR (brain) only shows some minor Changes in frontal cortex (that however are within the normal range according to one Swedish doctor).