Macrophage Markers Function and Activation

Regen Center Glossary

Macrophage are specific type of WBC or white blood cells, which are known to have a versatile functionality inside and for the immune system.

Dendritic Cells and Macrophages (VIDEO)

Macrophages are known as the body’s first line of defense against invasion from viruses and bacteria, Macrophages are generally responsible for safeguarding our inter-cellular environment by killing several types of bacterias.

During the time of infection or tissue damage,monocyte cells leave the bloodstream and rush to the affected organs such as liver and kidney or other tissues to differentiate into becoming become macrophages. These macrophage cells can modify themselves into forming different types of cell structures to fight different microbes and viruses.[1]


Humans macrophages are only about 22 micrometres in diameter.[2] They can survive for several. Macrophage cells are also involved in the development of innate immunities. Different macrophages have different protein markers on their exterior surfaces.

Examples of known macrophage markers include:

  • EMR1
  • MAC-1
  • MAC-3
  • CD11b
  • CD14
  • CD68
  • Lysozyme

Cellular Immunotherapy

Our stem cell doctors are able to identify such specific markers using a device known as a flow-cytometer.[3]

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Published Clinical Citations

  • [1] ^ Chatterjee, Priyajit, Soma Seal, Sandip Mukherjee, Rakesh Kundu, Sutapa Mukherjee, Sukanta Ray, Satinath Mukhopadhyay, Subeer S Majumdar, and Samir Bhattacharya. 2013. Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages. The Journal of biological chemistry, no. 39 (August 13). doi:10.1074/jbc.C113.495473.

  • [2] ^ Roger, Thierry, Julie Delaloye, Anne-Laure Chanson, Marlyse Giddey, Didier Le Roy, and Thierry Calandra. 2012. Macrophage migration inhibitory factor deficiency is associated with impaired killing of gram-negative bacteria by macrophages and increased susceptibility to Klebsiella pneumoniae sepsis. The Journal of infectious diseases, no. 2 (November 2). doi:10.1093/infdis/jis673.

  • [3] ^ Sun, Yu, Yu Wang, Jia-Hui Li, Shi-Hui Zhu, Hong-Tai Tang, and Zhao-Fan Xia. 2013. Macrophage migration inhibitory factor counter-regulates dexamethasone-induced annexin 1 expression and influences the release of eicosanoids in murine macrophages. Immunology, no. 2. doi:10.1111/imm.12135.