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Long-Term Self-Renewal

Regen Center Glossary

Long-term self-renewal in regen medicine refers to the capability stem cells have for self-replication through continuous division. The result of this natural regeneration cycle is common amongst certain types of non-specialized cells. The process of self-renewing usually occurs over a long period (that could even run for years), and the length and rate of self-renewal is determined on the specific stem cell variant.[1]

long-term-self-renewal-adult-cells

The introduction of self-renewing hepatoblast like cells or “HBCs” from human multipotent and pluripotent stem cells “PSCs” that has helped us provide a high quality and stable supply of mesenchymal hepatocyte-like cells for regenerative medical applications.[2]

Video about Long-Term  and Continuous Self-Renewal

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Published Clinical Citations

  • [1] ^ Deng, Y, X Zhang, X Zhao, Q Li, Z Ye, Z Li, Y Liu, et al. 2013. Long-term self-renewal of human pluripotent stem cells on peptide-decorated poly(OEGMA-co-HEMA) brushes under fully defined conditions. Acta biomaterialia, no. 11 (July 24). doi:10.1016/j.actbio.2013.07.017. https://www.ncbi.nlm.nih.gov/pubmed/23891809

  • [2] ^ Frelin, Catherine, Robert Herrington, Salima Janmohamed, Mary Barbara, Gary Tran, Christopher J Paige, Patricia Benveniste, et al. 2013. GATA-3 regulates the self-renewal of long-term hematopoietic stem cells. Nature immunology, no. 10 (August 25). doi:10.1038/ni.2692. https://www.ncbi.nlm.nih.gov/pubmed/23974957