Trophoblast Differentiation in Human Development

Regen Center Glossary

Trophoblasts are the outermost cell layer of a blastocyst primarily responsible for the implantation process [1]. A trophoblast develops into extra-embryonic tissues, and these include the placenta[2]


Trophoblasts also functions in controlling oxygen and metabolite exchange that transpires between the embryo and the mother [3]. Trophoblasts are also sometimes referred to as trophoderm. [4]


Published Clinical Citations

  • [1] ^ Hibaoui, Youssef, and Anis Feki. 2013. Human pluripotent stem cells as alternative models to study trophoblast development. Frontiers in physiology (December 17). doi:10.3389/fphys.2013.00374.

  • [2] ^ Morales-Prieto, D M, S Ospina-Prieto, A Schmidt, W Chaiwangyen, and U R Markert. 2013. Elsevier Trophoblast Research Award Lecture: origin, evolution and future of placenta miRNAs. Placenta (December 16). doi:10.1016/j.placenta.2013.11.017.

  • [3] ^ Red-Horse, Kristy, Yan Zhou, Olga Genbacev, Akraporn Prakobphol, Russell Foulk, Michael McMaster, and Susan J Fisher. 2004. Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. The Journal of clinical investigation, no. 6.

  • [4] ^ Taga, Shigeki, Junko Haraga, Mari Sawada, Aya Nagai, Dan Yamamoto, and Ryoji Hayase. 2013. A case of placental mesenchymal dysplasia. Case reports in obstetrics and gynecology (November 20). doi:10.1155/2013/265159.