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Stem Cell Treatment for Ataxia & Nerve Cell Regeneration

A patient-focused guide to Stem Cell Treatment for Ataxia & Nerve Cell Regeneration, with clinical context, evaluation considerations and supporting information.

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Ataxia occurs when the parts of the nervous system that coordinate movement are damaged or do not work properly, most often the cerebellum or its connections, the spinal cord, or the sensory nerves. Damage to these pathways disrupts the cell signaling capacity and neurotransmitters the brain uses to coordinate movement. It refers to a lack of muscle control or coordination of voluntary movements, such as walking or picking up objects. It may be due to various underlying neurological disorders that affect the cerebellum, the part of the brain that controls muscle coordination. In older adults, balance symptoms may also be worsened by vascular white-matter injury, so MRI reports that mention small-vessel disease should be reviewed alongside CSVD-related balance and gait problems.

What is Ataxia?

Friedreich’s ataxia is another type of Ataxia, but Friedreich’s is hereditary. In Friedreich’s ataxia, nerve fibers in the dorsal and lateral columns of the spinal cord and in the sensory nerves gradually degenerate, a pattern that differs from the lesions of Multiple Sclerosis or strokes. This rare inherited movement disorder, the most common hereditary ataxia, usually begins in childhood or adolescence and is accompanied by speech impairment (slurred speech, which differs from Aphasia, a language disorder), ataxia, scoliosis, peculiar movements, frequent hypertrophic cardiomyopathy, and even paralysis.[1]

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Anatomy guide

Brain anatomy

A lateral view of the cerebrum, cerebellum and brainstem.

1. Cerebrum
The large upper part of the brain.
2. Cerebellum
The folded structure at the lower back of the brain.
3. Brainstem
The stalk connecting the brain with the spinal cord.

Motor ataxia is the inability to coordinate muscles. Sensory ataxia occurs when the brain does not receive enough information about joint and limb position (proprioception), usually because of damage to the sensory nerves or the dorsal columns of the spinal cord. This loss results in uncoordinated movements, which become more apparent when an individual’s eyes are closed.

Ataxia-telangiectasia is a severe, progressive cerebellar ataxia characterized by abnormal eye movements, oculocutaneous telangiectasia, immunodeficiency, and sinopulmonary disease.[2]

Stem Cell Therapy for Spinocerebellar Ataxia

Neural Cell Treatment for Ataxia and Autoimmune cerebellar ataxia offers a promising treatment for those who can repair/reverse loss of motor neuron related brain damage. Stem cells are unspecialized cells that can develop into more specialized cell types. Pluripotent stem cells can form nearly any tissue, including neural cells such as astrocytes, while adult stem cells form a narrower range and can divide only a limited number of times in the laboratory. In laboratory studies, adult stem cells have been reported to form specialized cells, such as:[3]

The ability to generate new cells and tissues in the body indicates that adult stem cells can be used to replace diseased and damaged tissues, organs, and lesions, thereby treating Ataxia with Stem Cells. Learn more about stem cells. Some delivery methods, such as intrathecal infusions (injections into the spinal fluid) or fluoroscopically guided delivery in a hospital setting, are invasive procedures used to bypass the blood-brain barrier, and they carry procedural risks such as headache, infection, and bleeding.[4]

Our Ataxia protocol seeks to repair damaged and/or diseased tissues caused by injuries or hereditary conditions, such as Progressive Supranuclear Palsy & Spinal muscular atrophy.

Treating Sporadic Spinocerebellar Ataxia

Total Number of MSC+ Cell Infusions for Ataxia: For most patients with Ataxia, we will need multiple Infusions of isolated and expanded mesenchymal cells, which can be cultured from autologous bone marrow (BMMSC) or allogeneic sources (UC-MSC) such as the umbilical cord, placenta, and Wharton’s jelly. These cells can be combined with neural progenitor cells, fibroblast growth factors, cytokines, and chemokines to increase the survival rate of transplanted cells at each treatment stage.

Delivery Methods of MSC+ Cells for Ataxia: One of the main goals of treatment is to help reduce systemic neuroinflammation and promote faster recovery of any lost function through neurogenesis. The cells used in treatment can be administered via Stereotactic-guided delivery, inhalation therapy via micro-nebulized mesenchymal cells, Intravenously, Intrathecally, or fluoroscopy-guided delivery (hospital setting), which is sometimes needed to bypass the blood-brain barrier. A board-certified neurosurgeon performs the intrathecal stem cell deliveries.

Rehabilitation Treatment for Ataxia: Rehabilitation therapy is optional and can be performed 2-4 hours per day up to 6 days per week. Medical visas and accommodation packages for an extended stay can also be included at an additional cost.

Clinical guide

Cell sources and terminology

A guide to the source labels used in the laboratory illustration.

  1. Adipose tissue

    ADSC

  2. Bone marrow

    BM-MSC

  3. Peripheral blood

    PB-MSC

  4. Placental tissue

    P-MSC

  5. Umbilical cord

    UC-MSC

  6. UC-MSC+

    The Regeneration Center’s terminology used in this article.

Ataxia Treatment Guidelines for 2026

Neural cell treatment for Ataxia will require a minimum of 2 Weeks in Bangkok. Given the disease’s varying stages, our medical team will need to evaluate all potential patients before making medical recommendations. To begin the evaluation stage for our multi-stage treatment protocol, please contact us today.

Published Clinical Citations

[1] ^ Boonkongchuen, Pairoj, Sunsanee Pongpakdee, Panitha Jindahra, Chutima Papsing, Powpong Peerapatmongkol, Suppachok Wetchaphanphesat, Supachai Paiboonpol, et al. 2014. Clinical analysis of adult-onset spinocerebellar ataxias in Thailand. BMC neurology (April 5). doi:10.1186/1471-2377-14-75. https://www.ncbi.nlm.nih.gov/pubmed/24708620

[2] ^ Carlessi, Luigi, Elena Fusar Poli, and Domenico Delia. 2013. Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia. Experimental biology and medicine (Maywood, N.J.), no. 3. doi:10.1177/1535370213480703. https://www.ncbi.nlm.nih.gov/pubmed/23598976

[3] ^ Lolekha, Praween, and Kammant Phanthumchinda. 2009. Miller-Fisher syndrome at King Chulalongkorn Memorial Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, no. 4. https://www.ncbi.nlm.nih.gov/pubmed/19374296

[4] ^ Sutamnartpong, Panee, Sombat Muengtaweepongsa, and Kongkiat Kulkantrakorn. 2013. Wernicke’s encephalopathy and central pontine myelinolysis in hyperemesis gravidarum. Journal of neurosciences in rural practice, no. 1. doi:10.4103/0976-3147.105608. https://www.ncbi.nlm.nih.gov/pubmed/23546346