In the unfortunate event that you or perhaps a family member is coping with diabetes, you should be aware of its consequences on the body and mind. Diabetes is usually termed the “silent killer” mainly because it strikes the body slowly and without warning. Newly diagnosed diabetic patients are generally not worried about it since their symptoms are often no more severe than recurrent urination and increased thirst. Many others have no symptoms.
Understanding Hyperglycemia
As time goes by, however, the effects of both kinds of diabetes become increasingly severe and may lead to death. These symptoms include heart disease, eye issues, kidney failure, nerve damage, and erectile dysfunction, to name a few. Hypoglycemia (acute low blood sugar) and hyperglycemia (high level of blood sugar) are the key contributors to the effects of diabetes. Some oral diabetes medications, such as thiazolidinediones, can worsen heart failure in some patients, so medication choices should always be reviewed with a doctor.[1] That is precisely why it’s vital that women and men who are clinically diagnosed as “diabetic” immediately seek treatment to relieve hypoglycemia and hyperglycemia. These conditions often trigger more harmful, degenerative ailments. The Regeneration Center offers candidates with low passage Mesenchymal cell treatment for Diabetes that is used alongside existing prescribed diabetes medicines and insulin. Patients should not stop or reduce insulin or other diabetes medicines unless their own doctor advises it.[2]
Damage to Insulin-Producing Beta-Cells
Stem cell treatments for diabetes, used alongside functional medicine care, are being studied to see whether they can support insulin-producing cells in the pancreas or reduce the inflammation linked to insulin resistance, and their effect on blood sugar and complications is not yet established.
Hypoglycemia, or low blood sugar, is most often a side effect of insulin or some oral diabetes medicines, and it can be life-threatening if it is not treated immediately with fast-acting sugar or emergency care. Diabetic patients are treated by administering enhanced UC-MSC+ cells to the pancreatic area via IV infusion or directly (for severe cases). Diabetes is a metabolic disease with a significant inflammatory component, in which blood sugar levels are elevated because the body cannot produce enough insulin or cells no longer respond to the insulin produced naturally. The high blood sugar levels cause signs such as polyuria or frequent urination, polydipsia or an abnormal increase in thirst, and polyphagia or increased hunger, and, in severe cases, blurred vision, weight loss and dehydration.[3] High blood sugar can also follow damage to the pancreas from pancreatitis or pancreatic cancer, or the steroid medicines used for conditions such as lupus disease.
3 Types of Diabetes Mellitus:
Type 1 vs Type 2 Diabetes
Type 2 diabetes results from insulin resistance, a condition in which cells cannot use insulin effectively, combined with a gradual decline in insulin production that may eventually require insulin treatment. Type 2 is often an acquired disease, and early diagnosis with standard medical care, diet and exercise gives the best chance of good blood sugar control. Long-term risks of having diabetes include retinopathy (loss of vision), diabetic nephropathy, which leads to kidney failure, peripheral neuropathy (foot ulcers that lead to amputations or Charcot’s joints), and autonomic neuropathy that causes genitourinary, gastrointestinal, cardiovascular symptoms with sexual dysfunction. Patients diagnosed with diabetes also report increased occurrences of peripheral arterial disease (PAD), atherosclerotic cardiovascular disease, and cerebrovascular disease. Other complications include hypertension and severe abnormalities of lipoprotein metabolism. Many patients can also impair beta-cell insulin secretion due to their medications. These medications do not directly cause diabetes, but they may lead individuals to become insulin-resistant. Learn more about foods that fight inflammation
Pancreas and pancreatic islets
The pancreas beside an enlarged view of an islet and surrounding pancreatic tissue.
Gestational Diabetes is when pregnant women who’ve never had diabetes before have a high blood glucose level while being pregnant. It may precede the development of type 2 DM.- We cannot treat Gestational diabetes with stem cell therapy.
- FPG, fasting plasma glucose
- HNF, hepatocyte nuclear factor
- GAD, glutamic acid decarboxylase
- GDM, gestational diabetes
- GCT, a glucose challenge test
- IFG, impaired fasting glucose
- MODY, maturity-onset diabetes (young)
- IGT impaired glucose tolerance
Prevention of Diabetes
Type 1 diabetes cannot yet be prevented, but genetic risk tests and blood tests for diabetes-related autoantibodies can identify people at high risk before symptoms start, and one approved medicine, teplizumab, can delay its onset in some of them. Understanding potential risk factors and environmental triggers is a proactive measure that helps delay/avoid the destruction of the body’s friendly insulin-producing cells. Several known factors can influence and expedite the development of type 2 diabetes. Lifestyle behaviors are the most influential factors. These lifestyle choices include frequent consumption of junk foods or an inactive, sedentary lifestyle. Research worldwide has shown that adopting a healthy lifestyle with regular physical activity and a balanced diet can help prevent type 2 diabetes.
Our recommendations for a healthy diet
- Eating at least three servings of vegetables every day (including green leafy vegetables)
- Choose water, tea, or coffee over fruit juices, sodas, or other sweetened beverages
- Use whole grains for bread, rice, or pasta instead of processed white bread, rice, or pasta
- Choose natural peanut butter over chocolate spreads or jam
- Eat lean cuts of white meat, seafood, or poultry instead of red meat & processed meat
- Eat nuts, fresh fruit, or unsweetened yogurt as a snack
- Eliminate tobacco and limit alcoholic intake to a maximum of one per day
- Eating up to three servings of fresh fruit every day
Long sedentary periods, bad diets, and inactivity characterize modern lifestyles worldwide. To help prevent diabetes, The Regeneration Center recommends engaging in 15-30 minutes of physical activity daily. Taking a holistic approach to disease prevention is critical for reducing the risk of type 2 diabetes and its deadly complications. While these changes may be easier to implement early in life, healthy lifestyles can immediately boost quality of life and improve health outcomes later in life.
Stem Cell Treatment for T2 Diabetes
UC-MSC+ Beta Stem Cells for Type 2
At this stage, cures for Type 1 diabetes or gestational diabetes are very, very low probability. A genetic component of the disease will require gene therapy to reprogram cells to prevent them from reverting to their compromised state; however, these solutions are still in clinical trials and have not been approved for clinical use. According to the international diabetes federation,
New research has also shown that some patients with myasthenia gravis (MG) also had type 2 diabetes mellitus (T2DM) before the onset of MG, which suggests that the onset of diagnosis of Myasthenia gravis may correlate with the history of Type 2 Diabetes. Type 2 diabetes can often be well controlled when it is caught early, before complications affect the immune system and other organs, through diet, exercise, weight management and medication. Standard treatment includes diabetes medications (Metformin, Thiazolidinediones, DPP-4 inhibitors, Meglitinides), dietary changes, and insulin therapy when needed to control blood glucose levels, and these remain the foundation of care. If metabolic diseases are left untreated, complications often occur and can include:
- Foot Complications / Ulcers
- SpA Spondyloarthritides Disorders
- Kidney Failure (Nephropathy) and PKD
- Ketones & DKA (Ketoacidosis)
- ARLD
- Juvenile rheumatoid arthritis
- Osteoarthritis and Gout
- Ulcerative colitis and Crohn’s disease – IBD
- High Blood Pressure & Hypertension ( leads to heart disease, eye problems )
- Reduced ejection fraction cardiomyopathy & DCM
- Brain Strokes
- HHNS – Hyperosmolar Hyperglycemic Nonketotic Syndrome
- Pancreas Cancer
- Damage to insulin-producing cells requires insulin pumps
- Primary Sclerosing Cholangitis
- Gastroparesis
Treat Diabetes with Functioning Beta Cell Transplants
Cell lineages and quantities will depend on the patient’s medical needs. Diabetics are most often treated with isolated and expanded UC-MSC+ Cells, along with ductal epithelial cells, β-cells & pancreatic islet-like cells. Older patients or those with severe cases with multiple underlying conditions will require enhanced allogeneic stem cells (cord tissue-derived with anti-HLA antibodies) differentiated into glucose-sensing, insulin-producing beta cells.[5]
Pancreatic islets and beta cells
The anatomical terms used in this section.
- Pancreatic islet
A cluster of hormone-producing cells within the pancreas.
- Beta cell
An islet cell that produces insulin.
- Insulin
A hormone involved in regulating blood glucose.
Diabetes Stem Cell Treatment Guidelines for 2026
The total number of stem cell infusions will depend on the patient’s medical needs and will include UC-MSC+ Mesenchymal stem cells, pancreatic progenitor cells, and pancreatic β-cells (insulin-producing β-cells).
Types of Cells and Delivery Methods: A combination of isolated and expanded mesenchymal stem cells, Pancreatic endocrine cells are differentiated into beta cells and delivered along with pancreatic progenitor cells are delivered to the patient via IV, Intrapancreatic Injections, Intraperitoneal Injections, or Intra-Arterial Injections, depending on patient needs.
Rehabilitation Treatment (Optional): Rehabilitation therapy (2 hours per day, 5 days per week), medical visas, and accommodations for an extended stay are available at an additional cost.
Cell sources and terminology
A guide to the source labels used in the laboratory illustration.
- Adipose tissue
ADSC
- Bone marrow
BM-MSC
- Peripheral blood
PB-MSC
- Placental tissue
P-MSC
- Umbilical cord
UC-MSC
- UC-MSC+
The Regeneration Center’s terminology used in this article.
Treating T2DM With Stem Cells
The cellular treatment for Diabetics and neogenesis of β-cells & pancreatic islets will require a minimum of 10-14 days in Bangkok. The costs of treating Type 2 Diabetes with UC-MSC+ cells will depend on several factors, including current health status and other underlying medical conditions. To better prepare, our medical team will need to review patients’ relevant medical information, genetic tests for risk variants found in diabetes (if available), and recent blood tests. Upon completion of the evaluation, we will provide our recommendations and treatment plan, including all medical-related costs for stem cell extractions and cell delivery. Stem cell therapy for diabetes success rates depend on the stage and severity. To learn more about the treatment of Onset DM using Adult stem cells, please contact us today.
Published Clinical Citations
[1]^ Kao, Der-I, and Shuibing Chen. 2012. Pluripotent stem cell-derived pancreatic β-cells: potential for regenerative medicine in diabetes. Regenerative medicine, no. 4. doi:10.2217/rme.12.27. https://www.ncbi.nlm.nih.gov/pubmed/22817630
[2]^ Sacks, Frank M, Michel P Hermans, Paola Fioretto, Paul Valensi, Timothy Davis, Edward Horton, Christoph Wanner, et al. 2013. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, no. 9 (December 18). doi:10.1161/CIRCULATIONAHA.113.002529. https://www.ncbi.nlm.nih.gov/pubmed/24352521
[3]^ Sacks, Frank M, Michel P Hermans, Paola Fioretto, Paul Valensi, Timothy Davis, Edward Horton, Christoph Wanner, et al. 2013. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries. Circulation, no. 9 (December 18). doi:10.1161/CIRCULATIONAHA.113.002529. https://www.ncbi.nlm.nih.gov/pubmed/24352521
[4]^ Sukpat, Supakanda, Nipan Isarasena, Jutamas Wongphoom, and Suthiluk Patumraj. 2013. Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress. BioMed research international (June 17). doi:10.1155/2013/459196. https://www.ncbi.nlm.nih.gov/pubmed/23844362
[5]^ Zhao, Yong, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Huimin Zhou, Zhaohui Yin, et al. 2013. Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial. BMC medicine (July 9). doi:10.1186/1741-7015-11-160. https://www.ncbi.nlm.nih.gov/pubmed/23837842