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MS, also known as disseminated sclerosis or encephalomyelitis disseminata, is a disorder in which the myelin sheath around the axons of the brain and spinal cord is damaged, leading to demyelination and scarring. In addition, a comprehensive spectrum of indications and symptoms is commonly referred to as Multiple Sclerosis. Autologous hematopoietic stem cell transplantation can be life-changing.
Over time, MS alters the ability of nerve cells, immune cells, and the spinal cord to communicate with one another. Nerve cells generally communicate by sending electrical signals down long fibers known as axons. Axons are wrapped in an insulating 
Sclerosis refers to scars, plaques, or lesions in the white matter of our brain and spinal cord, primarily composed of myelin. Although we know much about the mechanisms and symptoms of this degenerative disease, the causes of autoimmune multiple sclerosis MS) vs. myasthenia gravis remain relatively unknown. Several neurological and immune system symptoms can appear with MS disorder, and frequently, the symptoms progress to display severe physical and cognitive impairment. New symptoms for people with MS can occur rapidly or can occur slowly after related illnesses such as transverse myelitis. The slow onset of symptoms is characteristic of multiple sclerosis. The symptoms of MS can sometimes go away entirely on their own. Still, they can also lead to irreversible neurological degeneration seen in movement disorders, spinal cord injuries, Parkinson’s disease, Wernicke’s Aphasia, and particularly in Primary Progressive Multiple Sclerosis.[2] Neurological testing can help identify the disorder whose primary features are standard in various forms of MS: myelopathy in patients’ brains and spinal cords. The demyelinating disease primarily affects the CNS or central nervous system. A well-known type of demyelinating disease is known as Multiple Sclerosis or MS.[3]
MS is among the most severe and complex nervous system disorders to treat in regenerative medicine today. MS Disorder frequently invades specific regions of the human nervous system, causing intense exhaustion along with other relapsing MS symptoms and clear physical signs that can be readily identifiable using radiology scans such as MRI scans.
Clinical indications of MS include:
Lab evaluation for people with MS or relapsing MS usually requires detailed cytology of the patient’s cerebrospinal fluid, along with detailed protein analysis and Radiographic MRI scan examinations, recommended by the national MS society,, recommended by the national MS society, for areas around the encephalocele. Genetic tests and Radiographic exams look for multiple or isolated lesions in the brain. Stem cell research shows that over 65% of the patients treated for MS using neural progenitor cells, undifferentiated cells, interferon Beta, and HSCT (Hematopoietic stem cells) show improvement shortly after treatment. In contrast, some patients show continued improvement over several years.
Stem cells are (undifferentiated/undefined) cells with the ability of perpetual self-renewal and unique properties to produce specialized cells through cell division. Stem cells are typically classified as embryonic or adult stem cells. Embryonic stem cell lines (ESC) are pluripotent and can give rise to all cell types in the body and differentiate into different tissue types. Embryonic cells are acquired from the inner cell mass of a blastocyst, but they can lead to serious adverse events in people with progressive forms of MS. Due to strict safety standards, The Regeneration Center does not offer human embryonic stem cells or iPSC cells.
Adult stem cells are used to treat amyotrophic lateral sclerosis. Progressive MS can initiate the healing process by differentiating into multiple cell types and is considered crucial in stem cell treatments, such as autologous hematopoietic stem cell transplantation. Multipotent. The primary purpose of adult stem cells & immune stem cells is to treat and repair the body by providing specialized cells that reduce inflammation. This need usually arises from wear and tear, acute injury, disease, and infection. Adult stem cells, including immune cells, are found in many organs and damaged tissues throughout the body and are further classified based on their location. Adult stem cells are either:
Mesenchymal stromal cells and growth factors required to support essential functions are available in several settings, including those undergoing hematopoietic stem cell transplantation and mesenchymal stem cell therapy.
Mesenchymal stem cells have unique properties and can be cultured & differentiated (UC-MSC+) into many types of new cells, including:
More recently, reprogrammed pluripotent stem cells, known as induced pluripotent stem cells (iPSCs), offer potential therapies for people with secondary progressive MS. Induced pluripotent stem cells share features with embryonic stem cells; however, they carry a risk of tumorigenesis. This cancer risk can be reduced via transdifferentiation; however, the results have not been consistent or safe. Progenitor stem cells such as induced oligodendrocyte progenitor cells (iOPC), induced neural stem cells (iNSC), and oligodendrocytes (iOL) can also be derived from somatic adult cells, which can be used in stem cell treatment, via the process of transdifferentiation utilized in stem cell treatment
Hematopoietic stem cells have pluripotential and self-renewal ability but are found in less than 0.01% of all nucleated cells in the Bone Marrow. Hematopoietic stem cells are capable of forming all hematopoietic cell lines, including:
Isolated hematopoietic stem cells (HSCs) can self-renew and regenerate damaged nerves when transplanted into patients. HSC cell transplantation (HSCT) has been used for over 50 years as a therapeutic tool to fight cancer, high-dose immunosuppressive therapy to reduce the risk of MS relapses, and rebuild the immune system after chemotherapy using a type of stem cell treatment known as autologous hematopoietic stem cell transplantation.
Clinical studies and peer-reviewed studies have shown that hematopoietic stem cells & autologous hematopoietic stem cells are also effective in repairing nerve-insulating myelin caused by various autoimmune conditions, including autoimmune encephalomyelitis (experimental autoimmune encephalomyelitis) have become a viable alternative therapy (with an alternative to immunosuppressive and immunomodulatory medications needed in autoimmune diseases such as MS. Results are achieved by several ways including rebooting the immune system and elimination of autoantigen-reactive T and B lymphocytes along with increasing the populations of t regulatory cells,
The treatment effectiveness for MS therapies is measured in several ways, including:
Double-blind stem cell research has shown that UC-MSC+ mesenchymal cells act as catalysts for improving Inflammatory diseases, including active relapsing MS, which can be challenging to manage. Via several mechanisms, including:
Long-term benefits of UC-MSC+ stem cells for Neurological conditions, such as relapsing-remitting MS, can significantly impact daily life. This can include inhibited adaptive immune responses, stopping disease progression, creating new white blood cells, repairing nerve insulating myelin, inhibiting innate immune responses, and proliferation of regulatory T cells, white blood cells, B cells & stem cells found in various tissues. NK cells, a type of cell found in the immune system,
MS is generally not considered a hereditary disease. Still, there are over 100 genetic markers that have been identified as increasing the risk of getting MS. Clinical trials, mRNA vaccines, which hold potential, are being reviewed by the MS Society., and gene therapies are being developed to target genetic defects using several gene-editing methods including zinc finger nucleases, transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 systems. Gene testing is still in its early stages; however, the patients who underwent it showed improvement. The goal of these promising new treatments for MS is to combine stem cell therapy with genome editing or mRNA vaccines, which are currently in clinical trials.
The Regeneration Center has developed a multi-stage program to treat MS. Nerve Cells, nerve fibers, exosomes, brainstem cells, and neurons can properly regenerate damaged areas of nerve myelin and axons. In contrast, mesenchymal stem cells help to reverse any damage caused by autoimmune disease. This alone can slow, halt, or even reverse the progressive nature of MS. At the same time, enriched neural cells, glial cells, astrocytes, and neural progenitor cells are used to target existing brain lesions.
The total number and types of stem cells used in a cell therapy trial to treat MS show promise for MS treatment, which will depend on the patient’s medical needs.
Type of Injections: For patients with progressive or late-stage MS, treatment may require more aggressive combination therapy using different types of stem cells, including hematopoietic or umbilical cord stem cell transplantation (UC-MSC). To ensure long-term efficacy, cell infusions are performed over multiple sessions and do not require invasive surgery. Cells are commonly delivered intravenously via stem cell nebulizers, Intrathecally via Intrathecal Injections, or via fluoroscopy-guided delivery (in a hospital setting only) to bypass the blood-brain barrier.
Physical Rehabilitation Post-Therapy: Physical Rehabilitation therapy for people with relapsing MS is optional, depending on the patients’ travel/time constraints. Complete physical rehabilitation post-therapy can be provided upon request for 2-5 hours per day and up to 5 days per week. 
Medical visas and extended-stay accommodations for patients and their families can also be included upon request. Learn about a multiple sclerosis-friendly diet.
Given the varying degrees of existing medical conditions (EDS scores) and the stage of degeneration, our medical team will need to review a potential candidate’s current medical information before establishing a treatment protocol that does not increase risk. Upon acceptance, we can provide a more accurate assessment of the patient’s condition and the expected outcomes post-therapy. The final plan will include a daily treatment outline, the total number of nights required, and the complete, fixed medical-related expenses (excluding accommodations and flights). Stem Cell Therapy for MS will require roughly 14 days in Bangkok. To begin evaluating our multi-stage MS Treatment protocol, please prepare your recent medical records, such as Brain MRIs, CT Scans, or PET Scans, and contact us today.
To learn more about treating MS with isolated UC-MSC+ stem cells, please get in touch with us today.
[1] ^ Pipatpajong, Hemmarin, and Kammant Phanthumchinda. 2011. Neurofibromatosis type I-associated multiple sclerosis can manifest in people with secondary progressive MS. Journal of the Medical Association of Thailand, Chotmaihet thangphaet, no. 4. https://www.ncbi.nlm.nih.gov/pubmed/21591539
[2] ^ Laosanguanek, Naressak, Thaddao Wiroteurairuang, Sasitorn Siritho, and Naraporn Prayoonwiwat. 2011. Reliability of the Thai version of SF-36 questionnaire for evaluating quality of life in multiple sclerosis patients in a multiple sclerosis clinic at Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. https://www.ncbi.nlm.nih.gov/pubmed/21721432
[3] ^ Hou, Zong-liu, Ying Liu, Xi-Hong Mao, Chuan-yu Wei, Ming-yao Meng, Yun-hong Liu, Zara Zhuyun Yang, et al. 2013. Transplantation of umbilical cord and bone marrow-derived mesenchymal stromal stem cells in a patient with relapsing-remitting multiple sclerosis ms, progressive ms with neural cells adhesion & migration, no. 5 (October 30). doi:10.4161/cam.26941. https://www.ncbi.nlm.nih.gov/pubmed/24192520
