The Liver largest internal organ in the body and is located directly below the right lung. The Liver consists of the right lobe and left lobe, which comprises hepatocytes cells responsible for processing the nutrients from the blood. Hepatocytes help break down and store some nutrients and also help remove any waste from the body. The Liver also produces bile fluid that helps us break down drugs, alcohol, and other toxic waste in the blood, then passing from our body through stool and urine. A liver cancer diagnosis is often due to cancer metastasizing from a different area such as in myeloma and is therefore known as secondary liver cancer. The different types of cells in the Liver can result in many cancerous (malignant) and noncancerous (benign) tumors. These variations of tumors all have different causes, are must be treated differently.
Based on recent statistics from 2019, Liver cancer is the fourth most commonly occurring cancer in men and the eighth-most common cancer type in women. The total number of patients with primary liver cancer has nearly tripled since the 1980s due to liver disease growth due to conditions such as hepatitis C. Primary liver cancer generally tends to be diagnosed in patients in their 50s and 60s and is more frequently found in men.[1]
There are many liver cancer variations and each type is quite different in the way it develops and mutates over time. Treatment options also vary depending on the type, scale, and severity of the diagnosis. The three most common types of liver cancer include:
HCC is the most common form of primary liver cancer in the world. This type of cancer starts in the hepatocytes (liver cells), that process nutrients in the blood. HCC Cancer often develops as a single small tumor that spreads (metastasizes) to other organs and tissue in the body. Another type of HCC liver cancer starts as many tiny cancer nodules in the Liver (instead of a single tumor). This type of liver cancer is seen most often seen in patients with chronic hepatic tissue damage and liver cirrhosis. Many patients with hepatocellular carcinoma also have some other disease of the Liver that is causing inflammation and fibrotic scarring in the liver, including:
Intrahepatic cholangiocarcinoma (cancer of the Bile ducts), is the second most diagnosed type of primary liver cancer. This type of liver cancer usually starts bile duct cells (tube-like structures) that deliver bile; about 15% to 25% of cases of this type of cancers are intrahepatic cholangiocarcinomas. Many cholangiocarcinomas also start forming in the bile ducts outside the Liver.
These rare types of liver cancers usually form on the cell lining of blood vessels inside the Liver. Common causes of Angiosarcoma and Hemangiosarcoma include patients exposed to toxins such as thorium dioxide (Thorotrast) and vinyl chloride. Other known risk factors include environmental exposure to radium or arsenic and can also be diagnosed due to mutations in the DNA resulting in an inherited condition called hereditary hemochromatosis. In more than 40% of cases, the diagnosis is considered idiopathic as no clear link can be identified. [2]
Tumors from Hemangiosarcoma and Angiosarcoma cancer increase and are often too widespread to be treated surgically by the time they are discovered. In some cases, radiation therapy (Chemotherapy) might help slow the disease, but these methods often fail as these particular types of cancers are challenging to treat.
Also called fibrolamellar carcinoma, this type of hepatocellular carcinoma is quite rare and is considered less aggressive than other known liver cancer types. FLL-HCC usually develops in young adults and is often misdiagnosed as a type of focal nodular hyperplasia, a noncancerous liver tumor.
This rare type of primary liver tumor usually develops in children less than five years old. When seen under a microscope, the hepatoblastoma cells look very similar to fetal liver cells comprised of tissue that resembles bile duct cells, fetal liver cells, or mature liver cells. Hepatoblastomas is curable with chemotherapy or surgery, but the tumors become much harder to treat if they spread outside the Liver.
When liver cancer is found, it did not develop there but has metastasized (spread) from other organs in the body, including the colon, RCC Kidney Cancer, lung cancer, pancreas cancer, stomach, bowel cancer, prostate cancer, mesothelioma or breast cancer. Since this type of cancer has spread from another (primary) site, it is referred to as secondary liver cancer. These naming and treatment options for the tumors are based on the original primary site where it started. For example, cancer that started in the pancreas and spread to the Liver is called Pancreatic cancer, and not liver cancer. It is also treated like pancreatic cancer. In Europe and North America, secondary (metastatic) liver tumors are more commonly diagnosed than primary liver cancer, but the opposite is true for many parts of Asia (Thailand) and Africa.
Sometimes, the tumors found in the Liver are classified as noncancerous (benign). This type of cancer usually doesn’t cause any severe symptoms or discomfort. Benign liver tumors are often found by chance when a patient undergoes imaging tests for other health conditions. Common benign tumors in the Liver include:
When a patient is clinically diagnosed with liver cancer, oncologists will first try to determine if the cancer tumors have spread, and if so, how far. This diagnosis process is called
Stages for liver cancer can range from stage I (1) through IV (4). Generally speaking, the lower the stage number, the less cancer has spread. A higher stage (stage 4) means the liver cancer has spread more. Each patient’s cancer experience is unique, but cancers with similar stages generally have similar outlooks and are typically treated the same way. The staging systems vary around the world, but the most common systems include:
These different types of staging systems are usually not compared against each other, and usage depends alot on which part of the world you reside in. At this time, there is no universal staging system that all doctors in the world use.
Staging systems can often help oncologists determine outlook. Still, for treatment purposes, some doctors classify liver cancers much more simply, depending on whether they can be surgically cut out (resected). Resectable cancer means that the tumor can be removed via surgery (partial hepatectomy.) Other types of simple classifications include:
Unresectable liver cancer: Cancers that have not yet spread distant organs or lymph nodes but can’t be removed entirely via means of surgery are classified as unresectable cancers. These types of liver cancers include those that have spread through the entire liver organ or cannot be safely extracted due to proximity to sensitive areas around the Liver, including the veins, main arteries, or bile ducts.
Transplantable liver cancer (Potentially resectable) – If patients are healthy enough for surgical intervention, liver cancer can be removed entirely by either surgery or treated using immunotherapy or total liver transplant. This generally is an option for patients in stage 1 and some stage 2 cancers but requires that patients do not have liver cirrhosis or any other severe medical conditions. A minimal number of patients diagnosed with liver cancer have these types of tumors.
Inoperable liver cancer: If the liver cancer is small enough, in a safe place to be removed, but a patient is not healthy enough to have surgery, it will be classified as Inoperable. This usually occurs because a noncancerous part of the Liver might not be healthy enough (due to cirrhosis etc.). If the cancer is removed surgically, there might not be enough healthy liver tissue remaining for a properly functioning liver. This classification is also reached if a patient has comorbidities that would make surgery dangerous.
Advanced (metastatic) liver cancer: Cancers that have already spread to the lymph nodes or other organs in the body are classified as advanced. Most advanced liver cancers cannot be treated with surgery alone.
Common Symptoms associated with HCC & Liver Cancer include:
Major Risk Factors associated with cancer in the Liver include:
Hepatitis B or C infections or drinking too much alcohol are often contributors to scarring of the Liver. Asymptomatic viral infections from HBV cause more than 75 percent of primary liver cancers worldwide. Primary liver cancer caused by viral infections and hepatitis develops slowly over decades and often goes undetected. Preventative medical screening for infections helps prevent them from becoming advanced and causing cancer. Chronic systemic infections of Hepatitis C virus (HCV) and Hepatitis B virus (HBV)are major risk factors for developing liver cancer.[4]
Several types of medical tests can be done to detect or eliminate the possibility of liver cancer tumors. Standard diagnostic tests include:
Most patients diagnosed with liver cancers are treated with combinations of radiation therapy, chemotherapy, or surgery. Radiation based therapies are disadvantageous as the high-energy particle rays do not target the cancer cells and destroy healthy cells causing severe side effects. The levels of radiation exposure in chemotherapeutic doses must be limited to avoid organ toxicity. Therefore, the 21st Century approach requires more precisely targeted therapies that are capable of killing cancer cells while ignoring the healthy cells. The combination of modern immunological cancer therapies and stem cells is much more targeted and significantly less toxic while maintaining similar and often better results depending on the type, age, and diagnosis stage. Immune boosting therapies are also more effective in achieving long-term tumor immunosurveillance while reducing the chance of relapse.
Immunological therapies can increase long-term disease-free survival and are prescribed as adjuvant therapy for patients with low white blood cell counts. Stem cell therapy for liver cancer helps boost a patient immune system with a naturally produced growth factor to enhance the cancer-fighting capacity.[5]
Immunotherapy for liver cancer is quickly becoming a standard-of-care treatment and, in some cases, a complete cure. Immunotherapies refers to manipulating or mobilizing the patient’s immune system to treat or cure liver cancer. Immunological therapies can also be performed via manipulation of genes using NK Cells, Dendritic cells (DCs), Monoclonal antibodies therapy, Immune modulators, adoptive cell transfer, an oncolytic virus therapy, which is a virus-based delivery system of modified genes where the payload uses the viruses as a host to carry past the patient’s immune system.
Patients diagnosed with HCC who initially might have responded well to medications that target PD-1 protein (checkpoint inhibitors) can, over a short time, develop resistance to these therapies, significantly if cancer has metastasized from its primary location to spawn additional liver tumors. In such cases, genes encoded with tumor-associated antigens (TAA) induces a much for an adequate response from the immune system.
Earlier clinical trials on liver cancer focused on identifying the proliferating progenitor cells (CD34+) in human blood. These progenitor cells are stimulated by cytokines (GM-CSF and TNF-alpha) to differentiate into dendritic cells rapidly. For some cases, using a combination of IL-4 & GM-CSF helps to generate significantly larger quantities of cancer-fighting dendritic cells from monocytes and macrophages.
Immunological therapy for liver cancer might soon be the gold standard in the treatment of liver tumors for these reasons:
The Regeneration Center offers an alternative treatment for liver cancer using Chimeric Antigen Receptor T-Cell Therapy for cases with Metastatic Prostate Cancer that can treat or reverse symptoms depending on the patient’s stage and severity. The best defense from any cancer is first being informed about the disease to make an informed decision about current cancer treatment options using stem cells.
Our stem cell treatment for liver cancer are customized specific to patient needs. The individualized protocol helps patients fight cancer using traditional cancer treatment and alternative natural cellular-based therapies. For over a decade, our approach to integrated healthcare relies on research-based treatment plans comprehensive and specific to patient medical needs to ensure the highest chances of success. Our Cell Regeneration therapies offer a holistic approach to health care. We strive to fight cancer and alleviate underlying symptoms that can increase the patient’s quality of life. Our cancer stem cells treatment also focuses on long term remission by addressing potential underlying causes of the disease.
Some herbal based supplements might help treat some symptoms associated with liver cancer, but patients diagnosed with cancers need to be extra precautious before digesting any unknown herbal remedies. A compromised liver may have a much harder time breaking down or metabolizing some substances. In particular, patients with lung cancer have a challenging time processing alcohol. Since many herbal preparations and extracts are alcohol-based, liver cancer patients should always double-check all the ingredients before taking any herbs. Furthermore, some herbal supplements for liver cancer might cause excessive bleeding and prevent blood from clotting properly.
Primary liver cancer can be defeated. Our goal is to heal patients for sustained long term remission of liver cancer. Our hands-on approach to modern healthcare means that we will work with you and your primary care doctor to determine the best overall treatment options based on the stage and severity. Our medical evaluation requires evaluation of current medical records. For over 15 years our experienced cancer team has treated hundreds patients successfully. Immunotherapy is not appropriate for all cases but patients who are not responding to traditional treatments or those where surgery is not a good option can benefit. Please contact us so our team can review current medical records Radiology scans (CT, ultrasound, or MRI) and lab tests to target the tumor(s) better and destroy them using minimally invasive techniques.
We provide our patients with access to the most innovative cancer treatment techniques and immunotherapies with minimal side effects. The Regeneration Center also offers its patients comprehensive follow-up care and survivorship programs ( In Thailand only) for patients recovering from primary liver cancer.
The outlook for patients diagnosed with primary liver cancer has never been better. Thanks to modern medicine, many people survive the disease. The Regeneration center has cared for cancer patients worldwide who were diagnosed with different types of primary liver tumors and some rare types such as hepatoblastoma and angiosarcoma. To learn more about our stem cell treatment protocols for treatment of liver cancer please contact us today.
[1] ^ Wogan GN. Dietary factors and special epidemiological situations of liver cancer in Thailand. Cancer Res Nov;35(11 Pt. 2):3499-502. PMID: 1104156.
[2] ^ Sun, J. H., Luo, Q., Liu, L. L., & Song, G. B. (2016). Liver cancer stem cell markers: Progression and therapeutic implications. World journal of gastroenterology, 22(13), 3547–3557. https://doi.org/10.3748/wjg.v22.i13.3547
[3] ^ Xiao Y, Lin M, Jiang X, et al. The Recent Advances on Liver Cancer Stem Cells: Biomarkers, Separation, and Therapy. Anal Cell Pathol (Amst). 2017;2017:5108653. doi:10.1155/2017/5108653
[4] ^ Zhang, W., Mu, D., & Feng, K. (2017). Hierarchical potential differentiation of liver cancer stem cells. Advances in clinical and experimental medicine : official organ Medical University, 26(7), 1137–1141. https://doi.org/10.17219/acem/66343
[5] ^ Liu CY, Chen KF, Chen PJ. Treatment of Liver Cancer. Cold Spring Harb Perspect Med. 2015;5(9):a021535. Published 2015 Jul 17. doi:10.1101/cshperspect.a021535