Stromal Vascular Fraction SVF Cells

Stromal vascular fraction or SVF cells is a medical term that describes a heterogeneous kind of cell that are typically found in adipose “fat” tissue. SVF cells are not the same as “stem cells” and are generally used for cosmetic purposes. These types of cells constitute about 2/3rd of all cells in the human body.

SVF and Fat Stem Cells

The remaining cells are called adipocytes.[1] SVF Cells are complex cellular products that are made from fat. SVF cell family is quite diverse and contains dozens of types of cells,cytokines and growth factors.Stromal-vascular fraction or SVF cells include:

• Nerve cells
• Monocytes
• Regulatory T-cells used in NK Cell Treatment for Cancer
• Endothelial cells
• Macrophages including anti-inflammatory M2 macrophage
• Fibroblast-like interstitial cells
• Pre-adipocytes
• Mesenchymal stem cells (MSC)
• 

Recent advancements in Stromal Vascular Fraction (SVF) cell research have shown promising developments across various medical applications:

• Regenerative Capabilities in Neurological Disorders: Research has highlighted the potential of laser-activated SVF cells in restoring spinal cord architecture and improving functional outcomes in a multiple sclerosis, and brain injuries.  This approach demonstrates the neuroregenerative capabilities of SVF, offering a novel method for treating c5 spinal cord injuries and neurodegenerative diseases​ such as parkinson’s disease, ALS and MND​.
• Enhanced Osteoarthritis Treatment: Innovations include the development of SVF-gel, particularly with enhancements like tropoelastin (TE-SVF-gel). This formulation has shown effectiveness in osteoarthritis management by improving the rheological properties of the gel, potentially offering a more targeted and effective delivery of regenerative cells to degenerated joints​ ​.
• Bone Healing: SVF has been recognized for its significant potential in bone fracture healing. The fraction’s regenerative and anti-inflammatory effects are instrumental in enhancing bone formation and integrating new technological approaches with natural healing processes, showing superior outcomes compared to other stimulation methods like electrical or ultrasound stimulation.

These studies collectively highlight the ongoing expansion of SVF’s clinical applications, underscoring its versatility and potential in regenerative medicine.  At the Regeneration center of Thailand, Adipose derived SVF cells acquired through adipose tissue are mainly used in cosmetic stem cell applications such as stem cell breast or stem cell facelifts. There are also several studies and clinical trials underway to understand the use of SVF cells in regenerative medicine for conditions such as peripheral neuropathy, brain strokes, knee injuries, orthopaedic sport injuries,diabetes and arthritis.[2] SVF and Stromal cellshave demonstrated anti-inflammatory effects even using non-expanded cells. ^[3]

To learn more about Stromal Vascular Fraction Cells or if you have any other questions please contact us today.

Published Clinical Citations

[1] ^ Sukpat, Supakanda, Nipan Isarasena, Jutamas Wongphoom, and Suthiluk Patumraj. 2013. Vasculoprotective effects of combined endothelial progenitor cells and mesenchymal stem cells in diabetic wound care: their potential role in decreasing wound-oxidative stress. BioMed research international (June 17). doi:10.1155/2013/459196. https://www.ncbi.nlm.nih.gov/pubmed/23844362.

[2] ^ Jerareungrattan, Aungkura, Monnipha Sila-asna, and Ahnond Bunyaratvej. Increased smooth muscle actin expression from bone marrow stromal cells under retinoic acid treatment: an attempt for autologous blood vessel tissue engineering. Asian Pacific journal of allergy and immunology, no. 2-3. https://www.ncbi.nlm.nih.gov/pubmed/16252840.

[3] ^ Wang, Wei Z, Xin-Hua Fang, Shelley J Williams, Linda L Stephenson, Richard C Baynosa, Nancy Wong, Kayvan T Khiabani, and William A Zamboni. 2013. Analysis for apoptosis and necrosis on adipocytes, stromal vascular fraction, and adipose-derived stem cells in human lipoaspirates after liposuction. Plastic and reconstructive surgery, no. 1. doi:10.1097/PRS.0b013e3182729ff7. https://www.ncbi.nlm.nih.gov/pubmed/23271558.