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If the fetal brain is harmed in any way during pregnancy, delivery, or following birth, Cerebral Palsy can occur. CP is frequently accompanied by mental incapacitation, hearing loss, difficulty in speaking, lack of coordination, seizures, and blindness. About 25% of instances are brought about by prenatal forces like improper nutrition, x-rays, anemia, viruses, or premature delivery. About 40% of Cerebral Palsy patient diagnoses are brought on by hypoxia (the lack of oxygen), while other causes remain idiopathic (unknown).[1]
Children with Cerebral Palsy and Autism will likely show early signs of physical impairment. The type of bodily dysfunction, location, and extent of impairment vary from person to person. CP can affect the legs, arms, or face. In some extreme cases, it can affect a single limb, several limbs, or all limbs. Some women with autoimmune anti-phospholipid (APA) antibodies or anti-thyroid antibodies have a slightly higher risk of their children getting CP.
CP and its variants affect muscles and a child’s ability to control them properly. Muscles can sometimes contract too little or too much. Limbs can also become stiff over time and be forced into awkward, painful positions. Uneven muscle contractions can make the patient’s limbs shake, writhe, and tremble. A patient’s posture, coordination, and balance are also usually affected by CP. Simple tasks such as standing up, sitting down, and walking can be difficult for some, while others have difficulty grasping objects. Other complications of Cerebral Palsy include mental/intellectual impairment, frequent seizures, and hearing or vision or hearing impairments.
The Regeneration Center of Thailand offers an effective and efficient cell therapy option for all those with cerebral palsy. In contrast to conventional remedies, our stem cell protocol differs significantly in how we target brain tissue repair (similar to our treatments for Alzheimer’s and MS) and in what we do differently to restore/regenerate the patient’s physical functions. Stem cell therapy for CP focuses on the root cause rather than just the signs and symptoms.
Cell death and Entrapment neuropathy happen when cells are injured. However, these dead cells are surrounded by healthy and damaged cells. Gene therapy, Stem cells, and exosomes have the unique ability to stimulate the healing of injured cells by secreting cytokines. The objective of stem cell treatment for Cerebral Palsy would be to help repair injured cells in the immediate vicinity of the lesions. This targeted stimulation may enhance physical signs and symptoms, primarily through movements.[2]
The majority of patients who have received stem cell treatments for CP show improvements following the very first or sometimes second transplant. They continue to show improvement for about six months to 1 year. The results are permanent for most CP and motor neuron patients undergoing stem cell therapy.
Spastic monoplegia is a type of cerebral palsy that results from brain injuries. It is different from other types of CP. Monoplegia (mono = 1) causes a defect in the movement of 1 of the two limbs of the human body, usually an arm, which is either the left or the right side.
It’s incredibly rare, and many authorities consider it a form of hemiplegia with mild involvement of the other limb on the affected side. Monoplegia cerebral palsy results from a permanent lesion in the brain’s motor cortex, which may be total or partial. Like all other kinds of cerebral palsy and SMA, the condition is sometimes irrevocable, which means that there’s no opportunity for regeneration. [3]
CP and similar diseases like Ataxia and Global Aphaasia are identified via a process of elimination since many other diseases cause similar symptoms, such as brain tumors, metabolic diseases, Erb’s palsy, Progressive Supranuclear palsy, brachial plexus palsy, etc. Stem cell therapy for CP can offer genuine improvements for patients with Monoplegia.
Cord blood stem cells have been beneficial in patients with brain injuries. Cord tissue-derived stem cells can divide and differentiate into neural-like stem cells. These adult stem cells have been shown to migrate toward damaged regions and promote therapeutic processes, which may help repair brain damage. Cord blood stem cells are also highly responsive to the body’s immune response following an injury, by interacting directly with organs and immune cells that help the body repair itself.[4]
Total Number of MSC+ Cell Sessions Needed: For most CP patients, we recommend multiple Infusions of isolated and expanded mesenchymal cells, which can be cultured from autologous sources (dental pulp or bone marrow [BMMSC]) or allogeneic sources (UC-MSC) and Neural Stem cells (MSC–NSC). These expanded stem cells, along with our proprietary mix of growth factors, are combined to enhance the treatment’s therapeutic potential. The growth factors we isolate and culture are naturally occurring proteins in cells that stimulate cell growth, proliferation, healing, and differentiation, and are combined with stem cells to support brain repair and regeneration. Some of the growth factors we isolate for TBI patients include Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factors (FGFs), Insulin-like Growth Factor 1 (IGF-1), Glial Cell Line-Derived Neurotrophic Factor (GDNF), Brain-Derived Neurotrophic Factor (BDNF), and Nerve Growth Factor (NGF).
Delivery Methods of MSC+ and Neural Stem Cells: The types of cellular infusions will vary based on patient needs. However, our treatment aims to help reduce systemic neuroinflammation and promote faster recovery of lost cognitive function through neurogenesis. To achieve these results, the cells can be administered via a combination of Intravenous infusions, stereotactic-guided delivery, inhaled micro-nebulized mesenchymal cells, Intrathecal infusions, and fluoroscopy-guided cell delivery (in a hospital setting only). All intrathecal injections at The Regeneration Center are done by a board-certified neurosurgeon and are needed to bypass the blood-brain barrier. Healing the blood-brain barrier (BBB) can be a crucial part of CP treatment because it helps maintain the brain’s internal environment and protects it from harmful external substances.
Physical Rehabilitation Post-Treatment: Physical Rehabilitation therapy is optional, depending on the patients’ travel/time constraints. Post-therapy physical rehabilitation can be provided upon request for 2-5 hours per day, up to 6 days per week.
Medical visas and extended-stay accommodations for patients and families can also be included upon request.
Cell Therapy for CP using a combination of neural progenitor cells, mesenchymal stem cells, and growth factor complex will require a minimum of 10-14 days in Bangkok. Due to the varying degrees of existing medical conditions and the stage of degeneration, our neurological stem cell team will need to review the potential candidate’s medical condition before providing a detailed treatment protocol. Upon completion of the evaluation, a thorough treatment plan will be provided, including specifics, such as a day-by-day medical treatment outline with the exact number of required nights and the total medical-related costs (excluding accommodations or flights). To begin the medical review for our multi-stage Treatment protocol, please prepare your recent medical records, such as Genetic tests for MS, Brain MRIs, CT Scans, or PET Scans (Preferred ), and contact us today.
[1] ^ Wang, Xiaodong, Hezhen Hu, Rongrong Hua, Jing Yang, Pei Zheng, Xinxin Niu, Hongbin Cheng, et al. 2015. Effect of umbilical cord mesenchymal stromal cells on motor functions of identical twins with cerebral palsy: pilot study on the correlation of efficacy and hereditary factors. Cytotherapy, no. 2. doi:10.1016/j.jcyt.2014.09.010. https://www.ncbi.nlm.nih.gov/pubmed/25593078
[2] ^ Keeratisiroj, Orawan, Nuanlaor Thawinchai, Wantana Siritaratiwat, and Montana Buntragulpoontawee. 2015. Prognostic Predictors for Ambulation in Thai Children With Cerebral Palsy Aged 2 to 18 Years. Journal of child neurology, no. 13 (April 28). doi:10.1177/0883073815582267. https://www.ncbi.nlm.nih.gov/pubmed/25922262
[3] ^ Kułak-Bejda, Agnieszka, Piotr Kułak, Grzegorz Bejda, Elżbieta Krajewska-Kułak, and Wojciech Kułak. 2016. Stem cells therapy in cerebral palsy: A systematic review. Brain & development, no. 8 (April 20). doi:10.1016/j.braindev.2016.03.002. https://www.ncbi.nlm.nih.gov/pubmed/27004672
[4] ^ Kumban, Wannisa, Sugalya Amatachaya, Alongkot Emasithi, and Wantana Siritaratiwat. 2013. Effects of task-specific training on functional ability in children with mild to moderate cerebral palsy. Developmental neurorehabilitation, no. 6 (March 11). doi:10.3109/17518423.2013.772672. https://www.ncbi.nlm.nih.gov/pubmed/23477366
