Chemokines, critical components in the immune system, are small proteins that facilitate the migration and positioning of immune cells throughout the body. They are vital in maintaining the body’s defense against foreign invaders, such as bacteria and viruses. Understanding the fundamental principles of chemokine biology can significantly contribute to our knowledge and ability to help patients in the clinical and …
Parametric vs Nonparametric Statistics in Stem Cell Research
Stem cell research examines everything from gene expression to differentiation capacities to therapeutic potentials. With such diverse data types and complex experiments, researchers must determine the most appropriate statistical tests to analyze results. Parametric and nonparametric methods both play essential roles in stem cell data analysis. Parametric tests make assumptions about population parameters and rely on normally distributed data. Tests …
Intrathecal Delivery of Stem Cells in the Subarachnoid space
Stem cell therapy has emerged as a revolutionary new treatment approach for neurological and spinal disorders. One up-and-coming method of administering stem cells is an intrathecal application, which involves injecting the cells directly into the cerebrospinal fluid (CSF). This technique allows the stem cells to travel throughout the CSF and reach the brain and spinal cord, making it ideal for …
Back-to-work Blues? Deadly Heart attacks more common on Mondays
Recent studies indicate a higher prevalence of severe heart attacks, particularly on Mondays, at the onset of the workweek. Irish physicians delved into the medical records of more than 10,000 patients throughout Ireland who were hospitalized between 2013 and 2018 due to acute myocardial infarction. A ST-segment elevation myocardial infarction (STEMI), is characterized by the total obstruction of a crucial …
Fractalkine Cell Signaling Compound to Promote Remyelination
Multiple Sclerosis (MS), an autoimmune disease primarily affecting myelin and myelin-producing cells known as oligodendrocytes in the brain and spinal cord, is known to cause symptoms of varying severity. Manifestations can range from relatively mild symptoms, such as numbness and blurred vision, to more severe complications, including paralysis and memory problems. This debilitating disease affects approximately 3.2 million individuals worldwide. …
Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs)
Wharton’s Jelly, a gelatinous substance found within the umbilical cord, is a rich mesenchymal stem cells (MSCs) source. These MSCs possess unique properties that make them a valuable tool in regenerative medicine, tissue engineering, and immunomodulation. Lets discuss some advantages and applications of Wharton’s Jelly stem cells along with methods used for extraction and utilization in clinical applications[1]. Clinical application …